DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8478 and let-391

DIOPT Version :9

Sequence 1:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_491744.3	Gene:	let-391 / 182953	WormBaseID:	WBGene00006492	Length:	453	Species:	Caenorhabditis elegans

Alignment Length:	338	Identity:	63/338 - (18%)
Similarity:	120/338 - (35%)	Gaps:	128/338 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 SSSVDVTANTVKANTLKTGDATMDNVSLQE-AAKTPAPSQVYPLSANVVLENITEVSNEGVSMLV 221
            |..:|:.:|:..||.:  ...|:|::...: :..:.:|||.             :.||:.....:
Worm   160 SMDMDILSNSALANYI--SPPTIDSIFQSDPSTSSSSPSQF-------------QSSNQTTKQSI 209

  Fly   222 SPAGAEKEV-------AHVNEVVNEVSELIAKALKISADSVKPATSKLKVEAGKKRQSMSSTYSG 279
            .|  :|||:       |.:::|:|.|   :|:.|       .|...::.:|..:|...
Worm   210 YP--SEKEMEKAAISNARIDDVINTV---LARVL-------APIDEEIPIEEPEKAPQ------- 255

  Fly   280 AALPRPRRSYLPTTTAETRTYSFKQRMSVVVKTTLNSPARKRSVGGGVSLSRRSCLPVSKLTKSS 344
                  :|:|:                                                    |:
Worm   256 ------KRAYI----------------------------------------------------SN 262

  Fly   345 IRKSLAVTSV-----RSPEKIASKPAKTSTKSIPEKVFSCKNCSTTFRVKSLLDVHM-RMHD--- 400
            .|.:||..::     :.|.|||.. .:|.|   .||.|.|..|..:....|.|.||: |||.
Worm   263 RRATLAQCNICGLMLKHPSKIADH-IRTHT---GEKPFECGECGLSLSKASSLKVHIRRMHTGER 323

  Fly   401 PVDNG--------ANTLKRLNSNPVAAGVSKNRC--KFCDKNFALERALHIHLMQNCDKIPPSEK 455
            |.:..        .:::::.:...|..|:.:..|  |.|:..|    |..::||::.....|...
Worm   324 PFECTWRCGLSFVTDSVRKEHEMTVHTGIKRYTCVVKGCNAVF----ARRVYLMRHRKNAHPELF 384

  Fly   456 RKL-EFTELNHEK 467
            ..: :..::|||:
Worm   385 TPIFDHVQVNHEE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	8/22 (36%)
		C2H2 Zn finger	379..399	CDD:275368	7/20 (35%)
		C2H2 Zn finger	426..444	CDD:275368	5/19 (26%)
let-391	NP_491744.3	C2H2 Zn finger	59..79	CDD:275368
		zf-H2C2_2	73..96	CDD:290200
		C2H2 Zn finger	87..108	CDD:275368
		C2H2 Zn finger	116..137	CDD:275368
		C2H2 Zn finger	270..290	CDD:275368	4/20 (20%)
		zf-H2C2_2	286..304	CDD:290200	7/21 (33%)
		C2H2 Zn finger	298..319	CDD:275368	7/20 (35%)
		C2H2 Zn finger	327..347	CDD:275368	0/19 (0%)
		C2H2 Zn finger	357..377	CDD:275368	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100