DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8478 and ZNF354B

DIOPT Version :9

Sequence 1:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_478137.1	Gene:	ZNF354B / 117608	HGNCID:	17197	Length:	612	Species:	Homo sapiens

Alignment Length:	457	Identity:	100/457 - (21%)
Similarity:	150/457 - (32%)	Gaps:	112/457 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 APSQVYPLSANVVLENITEVSNEGVSM----LVS-------PAGAEKEVAHVN------------ 234
            |||| ..|..:|:|||...:.:.|:|.    ::|       |...||:.:.|:
Human    32 APSQ-RNLYRDVMLENYRNLVSLGLSFTKPKVISLLQQGEDPWEVEKDSSGVSSLGCKSTPKMTK 95

  Fly   235 --EVVNEVSELIAKALK-------------ISADSVKPATSK--------------LKVEAGKKR 270
              :..:...|.|.|.||             |..:.:|....|              |.|:...|.
Human    96 STQTQDSFQEQIRKRLKRDEPWNFISERSCIYEEKLKKQQDKNENLQIISVAHTKILTVDRSHKN 160

  Fly   271 QSMSST-YSGAALPRPRRSYLPTTTA--ETRTYSFKQRMSVVVKTTLNSPARKRSVGGGVSLSRR 332
            ...... |..:...:.:|.....|.:  |.:..||||..:::.::.:.:..:           |.
Human   161 VEFGQNFYLKSVFIKQQRFAKEKTPSKCEIQRNSFKQNSNLLNQSKIKTAEK-----------RY 214

  Fly   333 SCLPVSKLTKSSIRKSLAVTSVRSPEKIASKPAKTSTKSIPEKVFSCKNCSTTFRVKSLLDVHMR 397
            .|   |...|:.|..|    |:|..:|          ....||:|.||.|...|...|.|..|.|
Human   215 KC---STCEKAFIHNS----SLRKHQK----------NHTGEKLFKCKECLKAFSQSSALIQHQR 262

  Fly   398 MH------------DPVDNGANTLKRLNSNPVAAGVSKNRCKFCDKNFALERAL----HIHLMQN 446
            .|            ....:.|:..|.|.::.|.   ...|||.|.|:|:....|    .||..:|
Human   263 THTGEKPYICKECGKAFSHSASLCKHLRTHTVE---KCYRCKECGKSFSRRSGLFIHQKIHAQEN 324

  Fly   447 CDKIPPSEKRKLEFTELNHEKKAQLPK---IGGTSGINHPMTMPQKPQQRISTIPKLAPSQGTQS 508
            ..|..|..|.....|.|:..:|..|.|   :....|.....:...:..|||.|..|.........
Human   325 PHKYNPGRKASSYSTSLSGSQKIHLRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGR 389

  Fly   509 MAPPSVKKIPKNVAHAGVYRTPTKTVPCHICKQSFRSILEFTNHSLTVHGNNQLKKMTGREDAQS 573
            ....|...|.....|.|     .|...|:.|.:.|.||.....|.: :|...:|........|.|
Human   390 AFSQSASLIQHERIHTG-----EKPYRCNECGKGFTSISRLNRHRI-IHTGEKLYNCNECGKALS 448

  Fly   574 AH 575
            :|
Human   449 SH 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	9/21 (43%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..444	CDD:275368	8/21 (38%)
ZNF354B	NP_478137.1	KRAB	14..73	CDD:214630	12/41 (29%)
		KRAB	14..53	CDD:279668	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..102		3/25 (12%)
		COG5048	184..596	CDD:227381	71/304 (23%)
		C2H2 Zn finger	188..208	CDD:275368	5/19 (26%)
		C2H2 Zn finger	216..236	CDD:275368	8/36 (22%)
		zf-H2C2_2	228..253	CDD:290200	10/34 (29%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		zf-H2C2_2	256..281	CDD:290200	4/24 (17%)
		C2H2 Zn finger	272..292	CDD:275368	3/19 (16%)
		zf-C2H2	298..320	CDD:278523	7/21 (33%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..340		5/19 (26%)
		C2H2 Zn finger	356..376	CDD:275368	3/19 (16%)
		zf-H2C2_2	368..393	CDD:290200	5/24 (21%)
		C2H2 Zn finger	384..404	CDD:275368	2/19 (11%)
		zf-H2C2_2	396..421	CDD:290200	7/29 (24%)
		C2H2 Zn finger	412..432	CDD:275368	6/20 (30%)
		C2H2 Zn finger	440..460	CDD:275368	3/11 (27%)
		zf-H2C2_2	453..477	CDD:290200
		C2H2 Zn finger	468..488	CDD:275368
		zf-H2C2_2	480..505	CDD:290200
		C2H2 Zn finger	496..516	CDD:275368
		zf-H2C2_2	508..531	CDD:290200
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	536..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		zf-H2C2_2	564..589	CDD:290200
		C2H2 Zn finger	580..600	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12625
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950