DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snap24 and SNAP23

DIOPT Version :9

Sequence 1:	NP_524298.1	Gene:	Snap24 / 41193	FlyBaseID:	FBgn0266720	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	XP_016878181.1	Gene:	SNAP23 / 8773	HGNCID:	11131	Length:	224	Species:	Homo sapiens

Alignment Length:	197	Identity:	92/197 - (46%)
Similarity:	128/197 - (64%)	Gaps:	21/197 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QELQFKSGQVADESLESTRRMLALMDESKEAGIRTLVALDDQGEQLDRIEEGMDRINADMREAEK 78
            :|:|.::.|:.|||||||||:|.|..||::|||:|:..||:|.|||:|||||:|:||.||||.||
Human     7 EEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEK 71

  Fly    79 NLSGMEKCCGICVLPWKKVNIKDDG---ESAWKANDDGK----------------IVASQPQRVI 124
            .|:.:.||||:||.|..:  ..|.|   |:..|..:.||                :|:.||..|.
Human    72 TLTELNKCCGLCVCPCNR--FSDVGCFYETRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVT 134

  Fly   125 DERERGGMGAPPQSGYVARITNDAREDEMDENLGQVNSMLGNLRNMALDMGSELENQNKQVDRIN 189
            :.:.:.........||:.|||||||||||:|||.||.|:||||::|||::|:|::.||.|:.||.
Human   135 NGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRIT 199

  Fly   190 AK 191
            .|
Human   200 DK 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snap24	NP_524298.1	SNARE_SNAP25N_23N	18..82	CDD:277242	39/63 (62%)
		SNAP-25	93..148	CDD:395673	17/73 (23%)
		SNARE_SNAP25C	150..208	CDD:277238	25/42 (60%)
SNAP23	XP_016878181.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3065
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60093
OrthoDB	1	1.010	-	-		D495812at33208
OrthoFinder	1	1.000	-	-		FOG0000822
OrthoInspector	1	1.000	-	-		mtm8607
orthoMCL	1	0.900	-	-		OOG6_102919
Panther	1	1.100	-	-	O	PTHR19305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3593
SonicParanoid	1	1.000	-	-		X1125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750