DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snap24 and snap25a

DIOPT Version :9

Sequence 1:	NP_524298.1	Gene:	Snap24 / 41193	FlyBaseID:	FBgn0266720	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_571510.1	Gene:	snap25a / 30712	ZFINID:	ZDB-GENE-980526-468	Length:	204	Species:	Danio rerio

Alignment Length:	208	Identity:	117/208 - (56%)
Similarity:	157/208 - (75%)	Gaps:	7/208 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ENAEPRTELQELQFKSGQVADESLESTRRMLALMDESKEAGIRTLVALDDQGEQLDRIEEGMDRI 69
            |:::.|.||.::|.::.|:||||||||||||.|::|||:|||||||.||:|||||:|||||||:|
Zfish     3 EDSDMRNELADMQQRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQI 67

  Fly    70 NADMREAEKNLSGMEKCCGICVLPWKKVNIKDDGESAWKANDDGKIVASQPQRVIDERERGGMGA 134
            |.||::|||||:.:.|.||:|..|..|  :|.....||..|.|| :|||||.||:||||:..:
Zfish    68 NKDMKDAEKNLNDLGKFCGLCSCPCNK--MKSGASKAWGNNQDG-VVASQPARVVDEREQMAI-- 127

  Fly   135 PPQSGYVARITNDAREDEMDENLGQVNSMLGNLRNMALDMGSELENQNKQVDRINAKGDANNIRM 199
              ..|::.|:|:||||:||||||.||..::||||:||||||:|::.||:|:|||..|.|:|..|.
Zfish   128 --SGGFIRRVTDDARENEMDENLEQVGGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRF 190

  Fly   200 DGVNKRANNLLKS 212
            |..|:||..:|.|
Zfish   191 DEANQRATKMLGS 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snap24	NP_524298.1	SNARE_SNAP25N_23N	18..82	CDD:277242	47/63 (75%)
		SNAP-25	93..148	CDD:395673	22/54 (41%)
		SNARE_SNAP25C	150..208	CDD:277238	34/57 (60%)
snap25a	NP_571510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		8/21 (38%)
		SNARE_SNAP25N	10..82	CDD:277247	50/71 (70%)
		SNAP-25	91..139	CDD:279208	22/54 (41%)
		SNARE_SNAP25C	141..199	CDD:277238	34/57 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592308
Domainoid	1	1.000	119	1.000	Domainoid score	I5745
eggNOG	1	0.900	-	-		E1_KOG3065
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13311
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3416
OMA	1	1.010	-	-		QHG60093
OrthoDB	1	1.010	-	-		D1197028at2759
OrthoFinder	1	1.000	-	-		FOG0000822
OrthoInspector	1	1.000	-	-		mtm6608
orthoMCL	1	0.900	-	-		OOG6_102919
Panther	1	1.100	-	-	O	PTHR19305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3593
SonicParanoid	1	1.000	-	-		X1125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800