DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snap24 and Snap25

DIOPT Version :9

Sequence 1:	NP_524298.1	Gene:	Snap24 / 41193	FlyBaseID:	FBgn0266720	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_001277985.1	Gene:	Snap25 / 20614	MGIID:	98331	Length:	206	Species:	Mus musculus

Alignment Length:	208	Identity:	120/208 - (57%)
Similarity:	160/208 - (76%)	Gaps:	5/208 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ENAEPRTELQELQFKSGQVADESLESTRRMLALMDESKEAGIRTLVALDDQGEQLDRIEEGMDRI 69
            |:|:.|.||:|:|.::.|:||||||||||||.|::|||:|||||||.||:|||||||:||||:.|
Mouse     3 EDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLDRVEEGMNHI 67

  Fly    70 NADMREAEKNLSGMEKCCGICVLPWKKVNIKDDGESAWKANDDGKIVASQPQRVIDERERGGMGA 134
            |.||:||||||..:.||||:.:.|..|:...|..:.||..|.|| :|||||.||:||||:..:
Mouse    68 NQDMKEAEKNLKDLGKCCGLFICPCNKLKSSDAYKKAWGNNQDG-VVASQPARVVDEREQMAI-- 129

  Fly   135 PPQSGYVARITNDAREDEMDENLGQVNSMLGNLRNMALDMGSELENQNKQVDRINAKGDANNIRM 199
              ..|::.|:||||||:||||||.||:.::||||:||||||:|::.||:|:|||..|.|:|..|:
Mouse   130 --SGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRI 192

  Fly   200 DGVNKRANNLLKS 212
            |..|:||..:|.|
Mouse   193 DEANQRATKMLGS 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snap24	NP_524298.1	SNARE_SNAP25N_23N	18..82	CDD:277242	47/63 (75%)
		SNAP-25	93..148	CDD:395673	23/54 (43%)
		SNARE_SNAP25C	150..208	CDD:277238	34/57 (60%)
Snap25	NP_001277985.1	SNARE_SNAP25N	10..82	CDD:277247	51/71 (72%)
		SNAP-25	91..141	CDD:395673	23/54 (43%)
		SNARE_SNAP25C	143..201	CDD:277238	34/57 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847095
Domainoid	1	1.000	125	1.000	Domainoid score	I5454
eggNOG	1	0.900	-	-		E1_KOG3065
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13311
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3279
Isobase	1	0.950	-	0	Normalized mean entropy	S1520
OMA	1	1.010	-	-		QHG60093
OrthoDB	1	1.010	-	-		D495812at33208
OrthoFinder	1	1.000	-	-		FOG0000822
OrthoInspector	1	1.000	-	-		mtm8842
orthoMCL	1	0.900	-	-		OOG6_102919
Panther	1	1.100	-	-	O	PTHR19305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3593
SonicParanoid	1	1.000	-	-		X1125
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750