DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snap24 and ric-4

DIOPT Version :9

Sequence 1:	NP_524298.1	Gene:	Snap24 / 41193	FlyBaseID:	FBgn0266720	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_001123033.1	Gene:	ric-4 / 179427	WormBaseID:	WBGene00004364	Length:	234	Species:	Caenorhabditis elegans

Alignment Length:	209	Identity:	116/209 - (55%)
Similarity:	150/209 - (71%)	Gaps:	13/209 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AEPRTELQELQFKSGQVADESLESTRRMLALMDESKEAGIRTLVALDDQGEQLDRIEEGMDRINA 71
            |:...||:.|.....:...||||||||||||.:|||||||:|||.||||||||:|.|..:|.||.
Worm    32 ADMSDELKGLNVGIDEKTIESLESTRRMLALCEESKEAGIKTLVMLDDQGEQLERCEGALDTINQ 96

  Fly    72 DMREAEKNLSGMEKCCGICVLPWKKVNIKDDGE-----SAWKANDDGKIVASQPQRVIDERERGG 131
            ||:|||.:|.|||||||:|||||.|.   ||.|     .|||.:|||.:::.||:..:.:...|
Worm    97 DMKEAEDHLKGMEKCCGLCVLPWNKT---DDFEKTEFAKAWKKDDDGGVISDQPRITVGDSSMG- 157

  Fly   132 MGAPPQSGYVARITNDAREDEMDENLGQVNSMLGNLRNMALDMGSELENQNKQVDRINAKGDANN 196
                ||.||:.:|||||||||||||:.||::|:|||||||:||.:|:.|||:|:|||:.|..:|.
Worm   158 ----PQGGYITKITNDAREDEMDENVQQVSTMVGNLRNMAIDMSTEVSNQNRQLDRIHDKAQSNE 218

  Fly   197 IRMDGVNKRANNLL 210
            :|::..||||.||:
Worm   219 VRVESANKRAKNLI 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snap24	NP_524298.1	SNARE_SNAP25N_23N	18..82	CDD:277242	41/63 (65%)
		SNAP-25	93..148	CDD:395673	22/59 (37%)
		SNARE_SNAP25C	150..208	CDD:277238	34/57 (60%)
ric-4	NP_001123033.1	SNARE_SNAP25N_23N	45..107	CDD:277242	41/61 (67%)
		SNAP-25	118..170	CDD:279208	22/59 (37%)
		SNARE_SNAP25C	172..230	CDD:277238	34/57 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164671
Domainoid	1	1.000	115	1.000	Domainoid score	I3775
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I2131
Isobase	1	0.950	-	0	Normalized mean entropy	S1520
OMA	1	1.010	-	-		QHG60093
OrthoDB	1	1.010	-	-		D1197028at2759
OrthoFinder	1	1.000	-	-		FOG0000822
OrthoInspector	1	1.000	-	-		otm14169
orthoMCL	1	0.900	-	-		OOG6_102919
Panther	1	1.100	-	-	O	PTHR19305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3593
SonicParanoid	1	1.000	-	-		X1125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890