DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mpi and MPI

DIOPT Version :9

Sequence 1:	NP_649940.1	Gene:	Mpi / 41192	FlyBaseID:	FBgn0286506	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_002426.1	Gene:	MPI / 4351	HGNCID:	7216	Length:	423	Species:	Homo sapiens

Alignment Length:	409	Identity:	156/409 - (38%)
Similarity:	235/409 - (57%)	Gaps:	45/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKNYGWGRKGINSAVAQLAMANDPDFRLNEEETYAEMWMGTHVCGVSVVKETGETLDRVLKKDLS 71
            |:.|.||:.|.||.||:|..::||..::.|::.|||:|||||..|.:.:.:     :|:.:|.||
Human    13 VQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILD-----NRISQKTLS 72

  Fly    72 -----------------------YLFKVLSINKALSIQVHPNKCEAERLHKERPDIYKDPNHKPE 113
                                   :||||||:...||||.||||..||:||.:.|..|.|.|||||
Human    73 QWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPE 137

  Fly   114 LAIALTPFLALVGFMSAEDIRDYIDEFQPLSKLIGKEAVDQL-----HDS-TNSESVKLCYEKLM 172
            :|||||||..|.||...|:|..::.:......|||.||...|     ||| ..:.|::.|:..||
Human   138 MAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLM 202

  Fly   173 KTEEPVIAKCISEIAKDY-QNELKSNDLLEVF----TKVNKDFPGDVGVLSLFFLNLIRLQPGQA 232
            |:|:.|:.:.::.:.|.. |.....|::.::|    .::::.:|||:|..:::||||:.|:||:|
Human   203 KSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEA 267

  Fly   233 IYLGANEIHAYLDGDCVECMACSDNVIRAGLTPKYKDVDQLLESVIF-ESSYKDRKEFIPYRI-- 294
            ::|.||..||||.||||||||||||.:|||||||:.||..|.|.:.: .||.|||. |:|.|.
Human   268 MFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRL-FLPTRSQE 331

  Fly   295 DDQVQVYIPPVSDFAVINVNIEHSLESYKLEIQAFGSILIVLKGSRILKLKTQQGDKEILVTRGS 359
            |..:.:|.|||.||.::...:..|:..||:......|||::::|:.|....|.|  ..|.:.||.
Human   332 DPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQ--TPIPLQRGG 394

  Fly   360 IVYIPVEAAPEIEFAQSDD 378
            :::|....:..::..:..|
Human   395 VLFIGANESVSLKLTEPKD 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mpi	NP_649940.1	cupin_like	2..373	CDD:304367	155/402 (39%)
Mpi	NP_649940.1	ManA	3..369	CDD:224399	155/398 (39%)
MPI	NP_002426.1	PMI_typeI	6..382	CDD:366531	149/374 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155679
Domainoid	1	1.000	259	1.000	Domainoid score	I2005
eggNOG	1	0.900	-	-		E1_COG1482
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1825
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3056
Isobase	1	0.950	-	0	Normalized mean entropy	S1186
OMA	1	1.010	-	-		QHG63421
OrthoDB	1	1.010	-	-		D1043197at2759
OrthoFinder	1	1.000	-	-		FOG0003110
OrthoInspector	1	1.000	-	-		oto90901
orthoMCL	1	0.900	-	-		OOG6_102059
Panther	1	1.100	-	-	LDO	PTHR10309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R741
SonicParanoid	1	1.000	-	-		X2082
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750