Protein Alignment Alg12 and ALG12

DIOPT Version :10

• Sequence 1: NP_649939.1
• Gene: Alg12 / 41191
• FlyBaseID: FBgn0037743
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_077010.1
• Gene: ALG12 / 79087
• HGNCID: 19358
• Length: 488
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 227/481 - (47%)
• Similarity: 311/481 - (64%)
• Gaps: 16/481 - (3%)

  Fly     4 LIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVVSIISAP 68
            |:...|..|||..|:|||||||||||.||:||...:..||||.::||||||||:||:|:::.|:|
Human    16 LLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVPRTFLGPVVIAVFSSP 80

  Fly    69 FVLLFETLSINKFWAQYVVRLVLA-GAISVAWNSLRQAVTKIYGVEVRLWFTAITITQFHFMFYM 132
            .|.:...|.::||::|.:||.||. |.|...| :|::.|.:.:|..|...|..:|..|||.|||.
Human    81 AVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLW-TLQKEVRRHFGAMVATMFCWVTAMQFHLMFYC 144

  Fly   133 TRPLPNIFALPIVLFAIAYWLRDQHKPFIICSGISILVFRSELALFLGILLVVSLLRRKVSIDGL 197
            ||.|||:.|||:||.|:|.|||.:...||..|..:|:|||.||.||||:||:::|..||||:...
Human   145 TRTLPNVLALPVVLLALAAWLRHEWARFIWLSAFAIIVFRVELCLFLGLLLLLALGNRKVSVVRA 209

  Fly   198 LKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGA 262
            |:.|:|||:..|..||.|||:|||:|.||||:||||||||||||||||||.||||||||||.:|.
Human   210 LRHAVPAGILCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGC 274

  Fly   263 SLVLVPIGVALEPRIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACACQRIWMNSAKS 327
            ||:.:|:|:.......|.|| ||.|:.|||:|||||||||||.||:|||.||..|..: :|:.|.
Human   275 SLLFIPLGLVDRRTHAPTVL-ALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYL-LNNYKK 337

  Fly   328 TW----HSFLALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTSNVSVHISNLAAQ 388
            :|    .|.|.:   .||::|...:...|.:|..|||||.|:.|||:|....::|.:||...|||
Human   338 SWLYKAGSLLVI---GHLVVNAAYSATALYVSHFNYPGGVAMQRLHQLVPPQTDVLLHIDVAAAQ 399

  Fly   389 SGVSRFMEINNEWTYSKDETMNYTQADLVAYTHLLVEAKNKQNTELWASLQNEFDTLEFIDCFNS 453
            :|||||:::|:.|.|.|.|.:. ....::||||:|:||.    ..|.|..::....|..:.....
Human   400 TGVSRFLQVNSAWRYDKREDVQ-PGTGMLAYTHILMEAA----PGLLALYRDTHRVLASVVGTTG 459

  Fly   454 IGIQYNSLLPVRIKTKPCIGILKKRP 479
            :.:....|.|..:..:..:.:|::.|
Human   460 VSLNLTQLPPFNVHLQTKLVLLERLP 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alg12	NP_649939.1	PMT_2	3..351	CDD:473917	185/351 (53%)
ALG12	NP_077010.1	PMT_2	19..354	CDD:473917	183/340 (54%)