DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8412 and Alg12

DIOPT Version :9

Sequence 1:	NP_649939.1	Gene:	CG8412 / 41191	FlyBaseID:	FBgn0037743	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001101574.2	Gene:	Alg12 / 315212	RGDID:	1304826	Length:	488	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	218/425 - (51%)
Similarity:	298/425 - (70%)	Gaps:	7/425 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVVSIISAP 68
            |:...||.|||..|:|||||||||||.||:||.:.:..:||||::||||||||:|||:::..|:|
  Rat    17 LLVTVAAIHLVACPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLGPLLIAAFSSP 81

  Fly    69 FVLLFETLSINKFWAQYVVRLVLA-GAISVAWNSLRQAVTKIYGVEVRLWFTAITITQFHFMFYM 132
            .|.:...|.:::|::|.:||.||. |.|...| :|::||.:.:|..|.:.|..|:.||||.|||.
  Rat    82 VVYVLSLLEVSRFYSQLIVRGVLGLGVIFGLW-TLQKAVRQQFGATVAVMFCWISATQFHLMFYC 145

  Fly   133 TRPLPNIFALPIVLFAIAYWLRDQHKPFIICSGISILVFRSELALFLGILLVVSLLRRKVSIDGL 197
            ||.|||:.||.:||.|:..||:.:...|:..|...|:.||:|||:.|||:|:::|.:|::|:..|
  Rat   146 TRTLPNVLALAVVLPALTAWLQHRWAVFVWLSAFVIIGFRAELAMLLGIMLLLTLYQRRMSVARL 210

  Fly   198 LKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGA 262
            |:.|:|||:..|..||.|||:|||.|:||||.||||||||||||||||||.||||||||||.:|.
  Rat   211 LQHAIPAGILCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGC 275

  Fly   263 SLVLVPIGVALEPRIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACACQRIWMNSAKS 327
            ||:.:|:| |::.|...|.|.:|.||.|||:|||||||||||.||||||.||..|..: :|  |.
  Rat   276 SLLFIPLG-AVDRRTFALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYV-LN--KK 336

  Fly   328 TW-HSFLALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTSNVSVHISNLAAQSGV 391
            :| :...||....|:::||..|...|.:|..|||||.|:.|||.|....::|.|||...|||:||
  Rat   337 SWPYKVRALLVFGHVVVNVASTATSLYVSHFNYPGGVAMQRLHELVPPQTDVLVHIDVAAAQTGV 401

  Fly   392 SRFMEINNEWTYSKDETMNYTQADLVAYTHLLVEA 426
            |||:::|::|.|.|.|.:....|.::.|||:::||
  Rat   402 SRFLQVNDDWRYDKREDVQLGAAGMLDYTHIIMEA 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8412	NP_649939.1	PMT_2	3..351	CDD:304453	183/348 (53%)
Alg12	NP_001101574.2	PMT_2	17..405	CDD:419750	206/392 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350499
Domainoid	1	1.000	376	1.000	Domainoid score	I830
eggNOG	1	0.900	-	-		E1_KOG2516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36269
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1701
OMA	1	1.010	-	-		QHG55263
OrthoDB	1	1.010	-	-		D330169at2759
OrthoFinder	1	1.000	-	-		FOG0004217
OrthoInspector	1	1.000	-	-		oto97279
orthoMCL	1	0.900	-	-		OOG6_104021
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3480
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810