DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8412 and alg12

DIOPT Version :9

Sequence 1:	NP_649939.1	Gene:	CG8412 / 41191	FlyBaseID:	FBgn0037743	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_595429.2	Gene:	alg12 / 2540068	PomBaseID:	SPBC1734.12c	Length:	546	Species:	Schizosaccharomyces pombe

Alignment Length:	547	Identity:	169/547 - (30%)
Similarity:	266/547 - (48%)	Gaps:	83/547 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFVTAAAHLVY-TPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVVSIISA 67
            ::.||...:..| ||||||||||.:||:|||...|.:.::|||.::||.|.|:||..|.::::|
pombe    14 ILLVTCIGYYSYKTPFTKVEESFAMQAIHDIQTYRWDLSKYDHLEFPGAVKRSFIPSLFIAVLS- 77

  Fly    68 PFVLLFETLSINKFWAQYVVRLVLAGAISV---AW---NSLRQAVTKIYGVEVRLWFTAITITQF 126
                         :...:.|..:||...::   :|   ||:..:::|.:|......|...:..||
pombe    78 -------------YIPSWFVNPLLAARWTIGYLSWESMNSVSCSISKRFGTLSGALFILFSCAQF 129

  Fly   127 HFMFYMTRPLPNIFALPIVLFAIAYWLRDQHKPFIICSGISILVF-----RSELALFLGILLVVS 186
            |.::||:|||.|||.|.....:::..|::.:     ...||||||     |||:||.|..|::..
pombe   130 HLVYYMSRPLSNIFGLIATNHSLSLLLKNNY-----YGSISILVFAAAIVRSEIALLLMCLILPL 189

  Fly   187 LLRRKVSIDGLLKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWY 251
            ||:|::::..||.|.:.:.:..:.|:.|:||:||....|||.|...:|.|..|||:|||||| :|
pombe   190 LLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELEAFLFNVVEGKSSDWGTSPF-YY 253

  Fly   252 FYSALPRAM--GASLVLVPIGVALEPRIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAA 314
            ::..||...  ..:|:.:.|........|.|:...|.|:.:||.|.|||.|||||..|..|.|:|
pombe   254 YFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSIPWFNAASA 318

  Fly   315 CACQRIWMNSAKSTWHSF--LALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTSN 377
            .... :..|::|.....|  |.|...:.::.....:.|||.:....||||.||:||:.:| ....
pombe   319 IGAS-LCFNASKFGKKIFEILRLMFFSGIIFGFIGSSFLLYVFQYAYPGGLALTRLYEIE-NHPQ 381

  Fly   378 VSVHISNLAAQSGVSRFMEINNEWTYSK--DETMNYTQADLVAYTHLLVEAKNKQNTELWASLQN 440
            ||||:......:|::||.::.: |.|.|  |..|......:..:.:|:.|.....|
pombe   382 VSVHMDVYPCMTGITRFSQLPS-WYYDKTEDPKMLSNSLFISQFDYLITEDPESYN--------- 436

  Fly   441 EFDTLEFIDCFNSIGIQYNSLLP---------------VRIKTKPCIGILKKRPVAPKEA----- 485
              ||.:.|:..||     |:.:|               :|...:|...:..|:..|.|.|
pombe   437 --DTFDVIESVNS-----NTKIPILPKWLSNHIPREISIRNPAQPVYILANKKARATKPAAVDDY 494

  Fly   486 -SKTKEKIAKTKTYP-----VEKETLL 506
             |....|:.:.|.:|     |..:|||
pombe   495 SSFIGHKVDEIKLWPPIYRVVSPDTLL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8412	NP_649939.1	PMT_2	3..351	CDD:304453	121/362 (33%)
alg12	NP_595429.2	PMT_2	31..351	CDD:304453	114/340 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	173	1.000	Domainoid score	I875
eggNOG	1	0.900	-	-		E1_KOG2516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I920
OMA	1	1.010	-	-		QHG55263
OrthoFinder	1	1.000	-	-		FOG0004217
OrthoInspector	1	1.000	-	-		oto101343
orthoMCL	1	0.900	-	-		OOG6_104021
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2394
SonicParanoid	1	1.000	-	-		X3480
TreeFam	1	0.960	-	-
	13	12.860