DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8412 and Alg12

DIOPT Version :9

Sequence 1:	NP_649939.1	Gene:	CG8412 / 41191	FlyBaseID:	FBgn0037743	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001135829.1	Gene:	Alg12 / 223774	MGIID:	2385025	Length:	486	Species:	Mus musculus

Alignment Length:	485	Identity:	230/485 - (47%)
Similarity:	320/485 - (65%)	Gaps:	22/485 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVVSIISAP 68
            |:...|..|||..|:|||||||||||.||:||.:.:..:||||::||||||||:||||::..|:|
Mouse    17 LLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLGPLVIAAFSSP 81

  Fly    69 FVLLFETLSINKFWAQYVVRLVLA-GAISVAWNSLRQAVTKIYGVEVRLWFTAITITQFHFMFYM 132
            .|.:...|.::||::|.:||.||. |.||..| :|::.|.:.:|..|.:.|..|:.||||.|||.
Mouse    82 VVYVLSLLEVSKFYSQLIVRGVLGLGVISGLW-TLQKEVRQQFGATVAVMFCWISATQFHLMFYC 145

  Fly   133 TRPLPNIFALPIVLFAIAYWLRDQHKPFIICSGISILVFRSELALFLGILLVVSLLRRKVSIDGL 197
            ||.|||:.||.:||.|:..||:.:...|:..|...|:.||:|||:.|||.|:::|.:|::::..:
Mouse   146 TRTLPNVLALAVVLPALTAWLQRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARV 210

  Fly   198 LKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGA 262
            |:.|:|||:..|..||.|||:|||.|:||||.||||||||||||||||||.||||||||||.:|.
Mouse   211 LRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGC 275

  Fly   263 SLVLVPIGVALEPRIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACACQRIWMNSAKS 327
            ||:.:|:| |::.|...|.|.:|.||.|||:|||||||||||.||||||.||..|..| :|  |.
Mouse   276 SLLFIPLG-AVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYI-LN--KK 336

  Fly   328 TW-HSFLALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTSNVSVHISNLAAQSGV 391
            :| :...|:....|:|:||..|...|.:|..|||||.|:.:||.|....::|.:||...|||:||
Mouse   337 SWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGVAMQQLHELVPPQTDVLLHIDVAAAQTGV 401

  Fly   392 SRFMEINNEWTYSKDETMNYTQADLVAYTHLLVEAKNKQNTELWASLQNEFDTLEFIDCFNSIGI 456
            |||:::|::|.|.|.|.:.  .|.::.|||:|:||. ..:..|:........::|     .:.||
Mouse   402 SRFLQVNDDWRYDKSEDVG--AAAMLNYTHILMEAV-PGHPALYRDTHRVLASIE-----GTTGI 458

  Fly   457 QYNSL-LP---VRIKTKPCIGILKKRPVAP 482
            ..|.: ||   |.::||.   :|.:|.:.|
Mouse   459 SLNLMKLPPFDVNLQTKL---VLLERLLRP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8412	NP_649939.1	PMT_2	3..351	CDD:304453	183/348 (53%)
Alg12	NP_001135829.1	PMT_2	17..405	CDD:389829	204/392 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846996
Domainoid	1	1.000	373	1.000	Domainoid score	I887
eggNOG	1	0.900	-	-		E1_KOG2516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36269
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1784
Isobase	1	0.950	-	0	Normalized mean entropy	S1928
OMA	1	1.010	-	-		QHG55263
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004217
OrthoInspector	1	1.000	-	-		oto93736
orthoMCL	1	0.900	-	-		OOG6_104021
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2394
SonicParanoid	1	1.000	-	-		X3480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740