DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16908 and Tti1

DIOPT Version :9

Sequence 1:	NP_649937.1	Gene:	CG16908 / 41189	FlyBaseID:	FBgn0037741	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_083558.1	Gene:	Tti1 / 75425	MGIID:	1922675	Length:	1085	Species:	Mus musculus

Alignment Length:	1100	Identity:	245/1100 - (22%)
Similarity:	449/1100 - (40%)	Gaps:	155/1100 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IKPAVEGFIKEPSKDTLSVVERAIEGFNFGEMRIYQVQTVVPLVVKLDELTGENQELRTSLMNCL 75
            ::|......|..:.:.:..::..::..:...::..|...:.||...|.....:.:.|..|::.||
Mouse    14 LRPVCVQLTKTQTVENVEHLQTQLQAISDTALQELQQYILFPLRFALKTPGPKRERLVQSVVECL 78

  Fly    76 SNIVSKTYLADEKGLRSI---LVVVLQQVRDSKTASMRPNLSEEIKLAAVQCIFEALRRSTTDVV 137
            :.::|.|.:.:::.|:.:   |...|......|.|:    ||||:|||.:|.:...:..:..|::
Mouse    79 TFVLSSTCVREQELLQELFSELSACLYSPSSQKPAA----LSEELKLAVIQGLSTLMHSAYRDII 139

  Fly   138 ESFYVKETAMVIGQILIMLLEIIEQEKYRKLVQTAIQCLMMVFYVHDESDQ---VDVVLRSQVAN 199
            .:||.......:|..:.:||.:.||||.:::...|:|||.::....|..|.   :|.:.:.|:.:
Mouse   140 LTFYEPSILPRLGFAVSLLLGLAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGD 204

  Fly   200 TIFIFLPKVLIVLFKTSMKDDKVGETIKSMAIQALGRII-CIMFEETTNEFIKMRYDGDAFRKLF 263
            .:..|||.:...|.:....|.|.|.:|...:::...:.: .||.:|......|
Mouse   205 LLASFLPGISTALTRIITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPK------------ 257

  Fly   264 KNNEEAHQCDFTFFASKKATTEQNEERLHQMQTEL--RSHQWVAATSRHLRPIFAEMSI--LRTH 324
                          |..|...|      |::...:  |...||.:|...| .||.:..|  :..|
Mouse   258 --------------AQAKPVVE------HRVAALMIHREADWVKSTGDKL-AIFIKKIIDCVSVH 301

  Fly   325 SAIRVRESYSDMCCLLLKHCAYNLRGNFLHVLESVLALSEDENEKIAQRCRDTLLLLQQQ----- 384
            ...:||....:...:||..|..:|..:...:|:.::.|..||:.::..||...|..|..|
Mouse   302 PHWKVRLELVEFVEILLLKCTQSLVESTGPLLKVLVGLVNDESPEVQARCSTVLRRLADQKVVVG 366

  Fly   385 -ASSQDIFDENAEMLLDAHLNKWPRILHRCEDNEQFAELLFFKGFLRNVNTDKLQLLLLVPKNLE 448
             .:..||..|:...|    ....||:::..:|..:|:.|....|:|:.:. .|:.::|....:::
Mouse   367 SRALADILSESLHSL----ATSLPRLMNTQDDQGKFSTLSLLLGYLKLLG-PKVHVILNSVAHVQ 426

  Fly   449 MFVTCLLTALDQRPTRDLLNEEYSLRRIREGDSKGLAAEL-AKLPW-----RQFKYLSSRRTVDI 507
            .....|:..|:...|...:.||    |....|:...:||: |..||     |.|:..:..|...:
Mouse   427 RLSRALIQVLELEVTDVKMVEE----RRWNSDNLSASAEVSAARPWSRVQRRYFRCFTDERVFLL 487

  Fly   508 LYDIGALLGTEPTINRLVFDYCQEMIQQRSPSMNECVLLLTLMVT------------------PQ 554
            |..|..|||....:..|| |:..|:.........:..::|..:|.                  |:
Mouse   488 LRKICQLLGYYGDLYLLV-DHFMELYHTSVVYRKQAAMILNELVVGAAGLDVEDIHNKCPSMGPE 551

  Fly   555 EKKARGSRLVLAKLFLDQILRDEHWNLALQPDSAWRLKVNKPTHWFEDRTPGIYSSAIEVRTQDC 619
            |.:.      :.|..|::....|:|.|....::....:|......|:..|.|:::         |
Mouse   552 ELRE------IVKSILEEYTSQENWYLITCFEAEEGEEVMMKQQGFQAVTSGVHT---------C 601

  Fly   620 DSDDEQTEVVG------SRVTIADAQFNVLHTCLILDAVGHCARFIGDTFDRHIFLSLHKVLLKV 678
                   :||.      ...||.....|:...|:.|:.:|..|..:|..|...:..:|:.:|.|.
Mouse   602 -------QVVSFPALSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFRLLLMSALYPILEKA 659

  Fly   679 ASSNTIVHQAASFAFVSMQYALKYAEPSHFIECSTDYITFHLNALLKRSPDSTAAVDILTVVLQY 743
            .....::.|.|:...|.:.:|..|....|.|..::||:...::..|:.......|..:|..:|:.
Mouse   660 GDPTLLISQVATSTMVDICHACGYNSVQHLINQNSDYLVNGISLNLRHLALHPHAPKVLEAMLRN 724

  Fly   744 STRGNVPHLDSLFQTIREECSKSHQTTNVHSYLRVFKSFLNHVSDWHDDAAA----------EVD 798
            :....:|.:..:.|.:.....:.:. ....|::.|..:.|..::.|..|:.:          |..
Mouse   725 ADASLLPLVADVVQDVLATLDQFYD-KRAASFVSVLHALLAALAHWFPDSGSTGQLQQRSLEEEG 788

  Fly   799 TELP-------MQVDEEQNVLSTWMSVLERPKLLKDL-NGDTNMGDAEE------PAKDEADDAD 849
            .:||       ...|.||.|||....        ||: .|:.:..:|||      |..||.|...
Mouse   789 RQLPAAGEASTTAEDIEQFVLSYLQE--------KDVAEGNVSDLEAEEEVQSAPPKVDENDTLP 845

  Fly   850 DTEEKPTKPVLPRHVEMVKDILGQVIKFISTADQGQQIAALECFSSGLPLLADYEDELLPLVHLV 914
            |.|     |.||.|:::.||::.:.|...:..:...::..|:.....:.:|..::::||||.|..
Mouse   846 DVE-----PPLPTHIQIAKDVMERCIHLSADKNLKIRLKVLDVLGLCVEVLQTHKNQLLPLAHRA 905

  Fly   915 WQPLIEKFRQKDALVLNRCFTLLHLLGVHAKDFILKRSLSDVIPQLKQFLKT-ASLHSSTETSQA 978
            |..|:.:....|.|.:.|.|.:|..||....||:..|...||:|:|...|.| |.:.:......:
Mouse   906 WPSLVHRLTSDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLTSSLITQAPISARAGPVYS 970

  Fly   979 QTQEYKLQLKLLKSLADFILGLQIEGRHLHEIMSTVVIYLSQIQPQELQTPARAFFLQLI 1038
            .|..:||||.:|:.|......|.:....|:::....|||||..||.:||..||:.||.|:
Mouse   971 HTLAFKLQLAVLQGLGPLCENLDLGEGDLNKVADACVIYLSTKQPVKLQEAARSVFLHLM 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
CG16908	NP_649937.1	None
Tti1	NP_083558.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..799	3/21 (14%)
Tti1	NP_083558.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..847	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834812
Domainoid	1	1.000	206	1.000	Domainoid score	I2900
eggNOG	1	0.900	-	-		E1_KOG4524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40969
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3697
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52444
OrthoDB	1	1.010	-	-		D75408at33208
OrthoFinder	1	1.000	-	-		FOG0004672
OrthoInspector	1	1.000	-	-		oto94218
orthoMCL	1	0.900	-	-		OOG6_104423
Panther	1	1.100	-	-	LDO	PTHR18460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1566
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800