DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pnn and PNN

DIOPT Version :10

Sequence 1:NP_001097727.1 Gene:Pnn / 41185 FlyBaseID:FBgn0037737 Length:307 Species:Drosophila melanogaster
Sequence 2:NP_002678.3 Gene:PNN / 5411 HGNCID:9162 Length:717 Species:Homo sapiens


Alignment Length:334 Identity:96/334 - (28%)
Similarity:166/334 - (49%) Gaps:57/334 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 VDDLEQKLNSAKQSLVILNENIRRIAGRVPKE---------------------SLQRSEKFKYTQ 53
            |..|:::|..||:||..::||||::.||.|.:                     ||.....|    
Human     5 VRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGF---- 65

  Fly    54 DGKKNEHNGDRPFPRNATPGGVFK---DKRRMYESK---NPISRFPIEENEGRPPRINSRVI--R 110
                ::..|..|..:....|.|.:   ::|...||:   :|      |:::.:.|.:.|.|:  .
Human    66 ----SDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDP------EDDDVKKPALQSSVVATS 120

  Fly   111 EMPTKKEIVEAQGTDSESRARNRRMFGSLLGTLQKFCQEESRLKSKEDKKAEIDRKVEKQELQER 175
            :..|::::::.|..|.:.:.||||:||.|:||||||.||.:....::.::.||::|:|.|..:||
Human   121 KERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEER 185

  Fly   176 AMLRKQRETLFLDRKKKQFEIRRLEYKMARMKDFKVWEATMLNAK--NNIRTKTKPHLFFRPKVH 238
            ..:..:|..||.:|:.||.|:|.||.|:...:..:.|...  |||  ..||||||||||:.|...
Human   186 KQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEH--NAKIIKYIRTKTKPHLFYIPGRM 248

  Fly   239 SPRTEKLLSKSKSEADVFIEFRREELEVELKNLE----NMNFGKMEDDTAIDESFYEEPDD---- 295
            .|.|:||:.:|:.:.:...|.||.|...::..:|    ..:..:.|.....:|....|.::    
Human   249 CPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVA 313

  Fly   296 --EEQLDKS 302
              ||:|:::
Human   314 QREEELEET 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PnnNP_001097727.1 Pinin_SDK_memA 126..250 CDD:461396 52/125 (42%)
PNNNP_002678.3 Pinin_SDK_N 1..130 CDD:461397 30/138 (22%)
Necessary for interaction with RNPS1 2..284 90/294 (31%)
Necessary for mediating alternative 5' splicing 2..167 47/175 (27%)
Necessary for interactions with KRT8, KRT18 and KRT19 2..98 24/100 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..139 18/106 (17%)
Pinin_SDK_memA 136..261 CDD:461396 53/126 (42%)
Sufficient for PSAP complex assembly 221..284 25/64 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 279..717 7/44 (16%)
Necessary for interaction with PPIG. /evidence=ECO:0000269|PubMed:15358154 606..717
Blue background indicates that the domain is not in the aligned region.

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