DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pnn and Pnn

DIOPT Version :9

Sequence 1:	NP_001097727.1	Gene:	Pnn / 41185	FlyBaseID:	FBgn0037737	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_032917.2	Gene:	Pnn / 18949	MGIID:	1100514	Length:	726	Species:	Mus musculus

Alignment Length:	331	Identity:	95/331 - (28%)
Similarity:	165/331 - (49%)	Gaps:	57/331 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEQKLNSAKQSLVILNENIRRIAGRVPKE---------------------SLQRSEKFKYTQDGK 56
            |:::|..||:||..::||||::.||.|.:                     ||.....|
Mouse     8 LQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGF------- 65

  Fly    57 KNEHNGDRPFPRNATPGGVFK---DKRRMYESK---NPISRFPIEENEGRPPRINSRVI--REMP 113
             ::..|..|..:....|.|.:   ::|...||:   :|      |:::.:.|.:.|.|:  .:..
Mouse    66 -SDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDP------EDDDVKKPALQSSVVATSKER 123

  Fly   114 TKKEIVEAQGTDSESRARNRRMFGSLLGTLQKFCQEESRLKSKEDKKAEIDRKVEKQELQERAML 178
            |::::::.|..|.:.:.||||:||.|:||||||.||.:....::.::.||::|:|.|..:||..:
Mouse   124 TRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQV 188

  Fly   179 RKQRETLFLDRKKKQFEIRRLEYKMARMKDFKVWEATMLNAK--NNIRTKTKPHLFFRPKVHSPR 241
            ..:|..||.:|:.||.|:|.||.|:...:..:.|...  |||  ..||||||||||:.|....|.
Mouse   189 ENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEH--NAKIIKYIRTKTKPHLFYIPGRMCPA 251

  Fly   242 TEKLLSKSKSEADVFIEFRREELEVELKNLE----NMNFGKMEDDTAIDESFYEEPDD------E 296
            |:||:.:|:.:.:...|.||.|...::..:|    ..:..:.|.....:|....|.::      |
Mouse   252 TQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQRE 316

  Fly   297 EQLDKS 302
            |:|:::
Mouse   317 EELEET 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pnn	NP_001097727.1	Pinin_SDK_memA	126..250	CDD:282541	52/125 (42%)
Pnn	NP_032917.2	Pinin_SDK_N	1..130	CDD:398394	34/150 (23%)
		Pinin_SDK_memA	136..261	CDD:398393	50/126 (40%)
		Sufficient for PSAP complex assembly. /evidence=ECO:0000250	221..284		20/66 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..522		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838333
Domainoid	1	1.000	96	1.000	Domainoid score	I7370
eggNOG	1	0.900	-	-		E1_KOG3756
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005515
OrthoInspector	1	1.000	-	-		oto92215
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12707
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1769
SonicParanoid	1	1.000	-	-		X5120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830