DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VII and CD276

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001019907.1	Gene:	CD276 / 80381	HGNCID:	19137	Length:	534	Species:	Homo sapiens

Alignment Length:	745	Identity:	134/745 - (17%)
Similarity:	231/745 - (31%)	Gaps:	296/745 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VPIHQIESIVGENIYLPCNVTTYDGDE--PVLVLWYRDDKGTPIYSIDIRAGVSKAPKRWSDDSV 85
            ||...:.::||.:..|.|:.:...|..  .:.::|...|....::|  ...|..:.....:..::
Human    33 VPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHS--FAEGQDQGSAYANRTAL 95

  Fly    86 FGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRV---DFLKAQTINSRIRLNVISPPKQVIIRDSS 147
            |.|    :..:....|.:|..:.:|.|::.|.|   ||..|     .:.|.|.:|    ..:.|.
Human    96 FPD----LLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSA-----AVSLQVAAP----YSKPSM 147

  Fly   148 NVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIPCELSHLAGGKIIECEITLPSLGR 212
            .:|.:..:.|   ||.|::.|....|||...:.| :||..:|     |.|      .:|...:..
Human   148 TLEPNKDLRP---GDTVTITCSSYQGYPEAEVFW-QDGQGVP-----LTG------NVTTSQMAN 197

  Fly   213 E----DLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPLSAGRRYDLLCQSAGSRP 273
            |    |::|.|..                           :|||:...|...|..:|.|.|
Human   198 EQGLFDVHSILRV---------------------------VLGANGTYSCLVRNPVLQQDA---- 231

  Fly   274 PAVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLSCKAYNHAVPSEPLEDGWKLD 338
                                       .|:::|:..:|..|                     .::
Human   232 ---------------------------HSSVTITPQRSPTG---------------------AVE 248

  Fly   339 IQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNV----FRIEWRHNE-QPLSHNISLG--- 395
            :| |||         ||.....|||....|.....|..    ..:.|:..: :.|.|:.:.|
Human   249 VQ-VPE---------DPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQ 303

  Fly   396 --------------VIISNHSLVLQGVTRATAGNYSC------VGFNAEGEGISAPFALNILYAP 440
                          :...|.||.||.|..|..|:::|      .|..|....::||:
Human   304 GSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPY-------- 360

  Fly   441 TCAQNQKKVYGIAKQEDAKVMCTVDANPREVEFSWTFNNSAESIDVATNHIIRSGTTSIVTYTPI 505
                                                   |..|:.:..|..:|.|.|
Human   361 ---------------------------------------SKPSMTLEPNKDLRPGDT-------- 378

  Fly   506 TELDYGTLLCLASNKIGKQRVPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSF 570
                                                            :|:|||.  ..|.|::
Human   379 ------------------------------------------------VTITCSS--YRGYPEA- 392

  Fly   571 NLELL--DSYTQEIKANITSTIPKFTVPGL-SPGSIYRLNIYAFNTKGRSDPAIVNAAMLRMPEK 632
              |:.  |.....:..|:| |.......|| ...|:.|:.:.|..|         .:.::|.|..
Human   393 --EVFWQDGQGVPLTGNVT-TSQMANEQGLFDVHSVLRVVLGANGT---------YSCLVRNPVL 445

  Fly   633 QLTSEQTHNLRAE-LLFSP-VMSLTIGLTLAVLVAVLAIILALRIPCTASSRRRQKELSNENISR 695
            |..:..:..:..: :.|.| .:.:|:||:    |.::|:::||...|.   |:.::....||...
Human   446 QQDAHGSVTITGQPMTFPPEALWVTVGLS----VCLIALLVALAFVCW---RKIKQSCEEENAGA 503

  Fly   696 DESPGPSD---------KSSGSKEVDDCDE 716
            ::..|..:         |.|.||| ||..|
Human   504 EDQDGEGEGSKTALQPLKHSDSKE-DDGQE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	21/106 (20%)
		V-set	32..134	CDD:284989	21/106 (20%)
		IGc2	160..>214	CDD:197706	15/57 (26%)
		Ig	262..328	CDD:299845	7/65 (11%)
		IG_like	264..323	CDD:214653	7/58 (12%)
		IGc2	360..425	CDD:197706	20/92 (22%)
		Ig_3	456..519	CDD:290638	6/62 (10%)
		FN3	538..620	CDD:238020	17/84 (20%)
		FAM176	643..741	CDD:291517	22/85 (26%)
CD276	NP_001019907.1	IG_like	37..138	CDD:214653	21/111 (19%)
		Ig	43..139	CDD:299845	20/106 (19%)
		Ig	148..231	CDD:299845	27/124 (22%)
		IG_like	156..237	CDD:214653	28/153 (18%)
		IG_like	255..356	CDD:214653	21/100 (21%)
		Ig	261..357	CDD:299845	20/95 (21%)
		Ig	366..449	CDD:299845	24/153 (16%)
		IG_like	374..456	CDD:214653	23/152 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..534		11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910