DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VII and Btnl2

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_524574.1	Gene:	Btnl2 / 547431	MGIID:	1859549	Length:	514	Species:	Mus musculus

Alignment Length:	638	Identity:	117/638 - (18%)
Similarity:	200/638 - (31%)	Gaps:	208/638 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VGENIYLPCNVTTYDGDEPVLVLWYRDDKGTPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDK 96
            |||:..|.|.:........:.|.|||.|...|:......|.|:..|...     :|.||.::.|.
Mouse    42 VGEDALLTCQLLPKRTTAHMEVRWYRSDPDMPVIMYRDGAEVTGLPMEG-----YGGRAEWMEDS 101

  Fly    97 -EPGK--LSIQNTQASDSGTYRCRV---DFLKAQTINSRIRLNVISPPKQVIIRDSSNVERSTVV 155
             |.|.  |.|:..|.||.|.|.||.   |:.:..::..::          ..:..|.|:.    |
Mouse   102 TEEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSVLLQV----------AALGSSPNIH----V 152

  Fly   156 GPYSEGDIVSLKCQVIGGYPTPTISWYRDGI----EIPCELSHLAG-GKIIECEITLPSLGREDL 215
            ....||: |.|.|...|.:|.|.:.|  :||    .:....:|:.| ..:...|.||  :.|.|.
Mouse   153 EGLGEGE-VQLVCTSRGWFPEPEVHW--EGIWGEKLMSFSENHVPGEDGLFYVEDTL--MVRNDS 212

  Fly   216 NSRLTCRALSHPRAPIVEAVVQID--MNFAPLNIRLLGAHQ--PLSAGRRYDLLCQSAGSRPPAV 276
            ...::|...||......||.:.:.  :.....::.::|..|  |:..|...:|.|
Mouse   213 VETISCFIYSHGLRETQEATIALSERLQTELASVSVIGHSQPSPVQVGENIELTC---------- 267

  Fly   277 ITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLSCKAYNHAVP---SEPLEDGWKLD 338
                                                           |..|   ::.||..| |.
Mouse   268 -----------------------------------------------HLSPQTDAQNLEVRW-LR 284

  Fly   339 IQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEWRHNEQPLSHNISLGVIISNHSL 403
            .:|.|..:|          ...||.|..:.:|         |::.....::..|..|.:    :|
Mouse   285 SRYYPAVHV----------YANGTHVAGEQMV---------EYKGRTSLVTDAIHEGKL----TL 326

  Fly   404 VLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANP 468
            .:.....:..|.|.|: |..:|....|...:.::...:..:..::|   .|....::.||.|...
Mouse   327 QIHNARTSDEGQYRCL-FGKDGVYQEARVDVQVMAVGSTPRITREV---LKDGGMQLRCTSDGWF 387

  Fly   469 REVEFSW------TFNNSAESIDVATNHIIRSGTTSIVTYTPITELDYGTLLCLASNKIGKQRVP 527
            ......|      |..:.:|:....:..:.:..|..:||
Mouse   388 PRPHVQWRDRDGKTMPSFSEAFQQGSQELFQVETLLLVT-------------------------- 426

  Fly   528 CVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITSTIPK 592
                                |.||  :.||||.....|..::....|.||..    |.:..|:|.
Mouse   427 --------------------NGSM--VNVTCSISLPLGQEKTARFPLSDSKI----ALLWMTLPV 465

  Fly   593 FTVPGLSPGSIYRLNIYAFNTKGRSDPAIVNAAMLRMPEKQLTSEQTHNLRAE 645
            ..:                       |..:...::::...:.|:||||:...|
Mouse   466 VVL-----------------------PLAMAIDLIKVKRWRRTNEQTHSSNQE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	30/107 (28%)
		V-set	32..134	CDD:284989	30/107 (28%)
		IGc2	160..>214	CDD:197706	17/58 (29%)
		Ig	262..328	CDD:299845	4/68 (6%)
		IG_like	264..323	CDD:214653	2/58 (3%)
		IGc2	360..425	CDD:197706	12/64 (19%)
		Ig_3	456..519	CDD:290638	9/68 (13%)
		FN3	538..620	CDD:238020	14/81 (17%)
		FAM176	643..741	CDD:291517	1/3 (33%)
Btnl2	NP_524574.1	IG_like	37..141	CDD:214653	30/103 (29%)
		Ig_MOG_like	43..142	CDD:143190	29/113 (26%)
		IG_like	257..358	CDD:214653	26/182 (14%)
		Ig_MOG_like	260..358	CDD:143190	26/179 (15%)
		Ig	<379..444	CDD:299845	17/112 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12214
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000