DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VII and Nphs1

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	968	Identity:	201/968 - (20%)
Similarity:	325/968 - (33%)	Gaps:	314/968 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GENIYLPCNVTTYDGDEPVLVLWYRDDK------GT----------------------------- 62
            |||:.|||  ....|:.|..:.|.::.|      ||
Mouse   272 GENLELPC--IARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSY 334

  Fly    63 ------------------PIYSIDIRAGVSKA---------------PK---RW---------SD 82
                              |..::.|....|::               |:   ||         :|
Mouse   335 NSVSAETQERSITLQVTFPPSAVTILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTD 399

  Fly    83 DSVFGDRAYFIFDKEPGKLSIQN----TQASDSG-TYRCRV--DFLKAQTINSRIRLNVISPPKQ 140
            ::|..       ....|.:|:.|    .:..|:| :..|..  |....:|....:.|||..|.::
Mouse   400 ETVMD-------GLHGGHISMSNLTLLVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYPAQK 457

  Fly   141 VIIRDSSNVERSTVVGP-----YSEGDIVSLKCQVIGGYPTPTISWYRDG--IEIP--------C 190
            :.|.           ||     ...|..|.|.|..|||.|.|:::|.:|.  :..|        .
Mouse   458 LWIE-----------GPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRV 511

  Fly   191 ELSHL-AGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQ 254
            :|..: ..|.....|:.| .:|..|..::.:|:|..      :.|..|:.:.|.|.|:.:|....
Mouse   512 QLGSVEKSGSTFSRELVL-IIGPPDNLAKFSCKAGQ------LSASTQLVVQFPPTNLTILANSS 569

  Fly   255 PLSAGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTETTSS---DGNQTTSTLSISLSKSDAGKY 316
            .|..|...:|.|.|..|.||..::..:.|.||:.......|   .|:..:.::.:.:|..|.|..
Mouse   570 ALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHR 634

  Fly   317 LSCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEW 381
            ::|:|::.|: .|.:...::|::.|.||.   ||..:...|:.|.........|.|:|......|
Mouse   635 VTCRAHSEAL-RETVSSFYRLNVLYPPEF---LGEQVRAVTVVEQGQALLPVSVSANPAPEAFNW 695

  Fly   382 RHNEQPLS------HNISLGVIISNHSLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAP 440
            ......||      |.     |:|..:|.|..||||..|.|.....|:||.. .|...|::.|||
Mouse   696 TFRGYRLSPAGGPRHR-----ILSGGALQLWNVTRADDGFYQLHCQNSEGTA-EALLKLDVHYAP 754

  Fly   441 TC-AQNQKKVYGIAKQEDAKVMCTVDANP------------------------------------ 468
            |. |........:....|  ::|||||||
Mouse   755 TIRALKDPTEVNVGGSVD--IVCTVDANPILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRLRI 817

  Fly   469 ----------------------------------------------------------------- 468

Mouse   818 RQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGV 882

  Fly   469 REVEFSWTFNNSAESIDVA----TNHIIRSGT--TSIVTYTPITEL-DYGTLLCLASNKIGKQRV 526
            ..::|:||.|  ...:|:.    |.|....|.  :|::|...::.. ||....|.|:|.:|....
Mouse   883 PNIDFTWTKN--GVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGSDHT 945

  Fly   527 PCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNL--ELLDS----YTQEIKAN 585
            .  ..:::..||:......|.::|..|:.:....||:|||||.|.:  |.|:|    |...:.|.
Mouse   946 N--IQLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLPQRFQIRYEALESPGFLYMDVLPAQ 1008

  Fly   586 ITSTIPKFTVPGLSPGSIYRLNIYAFNTKGRS-------DPAIVNAAMLRMPE---KQLTSEQTH 640
            .|:    ||:.||.|.:.||:.:.|.|..|.|       ..:|....:.:.||   :.|.:||..
Mouse  1009 ATT----FTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSITTPGLDQAPEDTDQPLPTEQPP 1069

  Fly   641 NLRAELLFSPVMSLTIGLTLAVLVAVLAIILALRIPCTASS--RRRQKELSNENISRDESPGPSD 703
            .       .|.:.|     |.||.||..::|.....|....  |||.:.|:.|...:.|:....|
Mouse  1070 G-------PPRLPL-----LPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEED 1122

  Fly   704 KSSGSKE----VDDCDEKNPDVVPESIEPDEQA------------ESIRKRQQISTID 745
            :.....|    ..|.|.::..|....::|...:            |.:..||..:.|:
Mouse  1123 RIRNEYEESQWTGDRDTRSSTVSTAEVDPHYYSMRDFSPQLPPTLEEVSYRQAFTGIE 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	29/187 (16%)
		V-set	32..134	CDD:284989	29/187 (16%)
		IGc2	160..>214	CDD:197706	17/64 (27%)
		Ig	262..328	CDD:299845	17/68 (25%)
		IG_like	264..323	CDD:214653	16/61 (26%)
		IGc2	360..425	CDD:197706	19/70 (27%)
		Ig_3	456..519	CDD:290638	22/170 (13%)
		FN3	538..620	CDD:238020	29/94 (31%)
		FAM176	643..741	CDD:291517	24/115 (21%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423
		Ig	254..332	CDD:299845	12/61 (20%)
		IG_like	268..350	CDD:214653	12/79 (15%)
		C2-set_2	358..440	CDD:285423	14/88 (16%)
		Ig	459..544	CDD:299845	22/96 (23%)
		I-set	460..555	CDD:254352	25/112 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		4/24 (17%)
		Ig	563..646	CDD:299845	20/83 (24%)
		IG_like	670..750	CDD:214653	24/85 (28%)
		Ig	676..750	CDD:299845	22/79 (28%)
		Ig_3	753..834	CDD:290638	12/82 (15%)
		IG_like	762..848	CDD:214653	8/87 (9%)
		Ig	848..956	CDD:299845	17/111 (15%)
		IG_like	859..949	CDD:214653	16/93 (17%)
		fn3	956..1039	CDD:278470	28/86 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		5/30 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810