DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VII and sns

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	1170	Identity:	219/1170 - (18%)
Similarity:	375/1170 - (32%)	Gaps:	384/1170 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELLLLFMLALQLIESSIGSKDVPIH-----QIESIVGENIYLPCNVTTYDGDEPVLVLWYRDDK 60
            :||.:||               .|.|     ..|:.||:.:.|.|  ||...:.|..:.|.
  Fly   372 VELSVLF---------------APTHVTVMGPTEARVGDIVPLTC--TTAPSNPPAEIKWM---- 415

  Fly    61 GTPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRV------D 119
               :....:|...||.                |...|.|..:..|..|......|..|      :
  Fly   416 ---VGGRQVRNATSKT----------------IVSPEGGWTTTSNITAVVEPNKRSLVVICHGLN 461

  Fly   120 FLKAQTINSRIRLNVISPPKQVIIRDSSNVERSTVVGPYSEGDIV------SLKCQVIGGYPTPT 178
            ....:.:.|...:||:.||...:|            ..|.||.|:      .|.|...||.|..|
  Fly   462 MQLTENVVSTHTINVLYPPAPPLI------------SGYMEGQIIPAGSVQKLLCVSSGGNPLAT 514

  Fly   179 ISWYRDGIEIPCELSHLAGGKIIECEITLPSLGREDLNSRLTCRAL-SHPRAPIVEAVVQIDMNF 242
            ::||::...|...:.  |..|.:..|||:.: ...|..::..|.|. |....|:.::.. :.::|
  Fly   515 LTWYKNDKRINSVIR--AADKSVSAEITILA-NVSDNQAQYRCEASNSATEIPLFQSTT-LSVHF 575

  Fly   243 APLNIRLLGAHQPLSAGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTETTSS---DGNQTTSTL 304
            ||..:::....:.|..|....::|.|:.|.|||.::||::||.:|....|:..   .|..:|...
  Fly   576 APETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEF 640

  Fly   305 SISLSKSDAGKYLSCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPSTLR---EGTDVYF 366
            .:::::...|:..:|::.|.|: .....:...||:.|.|: :|.     .||:..   ||..:..
  Fly   641 RVNVTQEMNGQVYTCQSANEAL-QRSAHEAVSLDVLYRPK-FVP-----PPSSTAVGVEGESLQV 698

  Fly   367 DCLVMAHPNVFRIEWRHNEQPLSHNISLGVIISNHSLVLQGVTRATAGNYSCVGFNAEGEGISAP 431
            .....|:|.....:|..:...:..:....:.....||....:.|..||.|||...|::| |.:..
  Fly   699 SLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQG-GATLN 762

  Fly   432 FALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANP--------------REVEFSWTFNNSA- 481
            ..:.:.|..|.....:.:. :...|||.:.|||:..|              ..|:.|.||.|..
  Fly   763 ITVVVEYGTTIKSVSENIV-VNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTS 826

  Fly   482 --------------------ESIDVATNHII-------------------RSGT----------- 496
                                ..:|..||..|                   .|||
  Fly   827 YLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQ 891

  Fly   497 ------------------------------------TSIVTYTPITELDYGTLLCLASNKIGKQR 525
                                                .|.:....:...|||...|:|.|::| :.
  Fly   892 GSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELG-EA 955

  Fly   526 VPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITSTI 590
            |..| .:....:|:...:..:.|::..::|:..:.||:|||..|:.:....:..::.|  ....:
  Fly   956 VETV-RLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYK--YIDGL 1017

  Fly   591 P---KFTVPGLSPGSIYRLNIYAFNTKGRSD--PAIVNAAMLRMPEKQ----------LTSEQTH 640
            |   |.|:.||...::|..::.::|..|:|.  |.:..|.....|...          .|:.||.
  Fly  1018 PNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTP 1082

  Fly   641 NLRAELLFSPVMSLTIGLTLAVLVAVLAIILALRIPCTASSR-----RRQKELSNENISRDESPG 700
                  |......|.:|:...::|.:|.:.:   |.|....|     :|..||....::.|.|..
  Fly  1083 ------LGGTSGMLLVGVGAGIVVVLLNVFV---IGCCLHKRNEKRLKRGLELMPAELTEDSSNT 1138

  Fly   701 PS---------------------------DKSSGSKEVDDCDEKNPDV---VPESIEPDEQAESI 735
            |:                           .:.....|..:...|...:   .|.|.......|::
  Fly  1139 PNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETL 1203

  Fly   736 RKRQQISTIDTNRSPNRGIFVNEQQHLTAAEISLRASHGIGYCTLRSGMHAQAQSSVGEISINVT 800
            ....:.|...:|...::..:::|.:...|:.          |....|.|........|.:
  Fly  1204 SSVSEKSESYSNEGSSQPEYIDEVRKKAAST----------YLVEGSDMPPPRYQKDGTL----- 1253

  Fly   801 PHVYSNS-ISQCTLPRQS------------------SQNVW------------NNYNCN------ 828
            |.:|.|: ::.||||...                  |:.|:            :.||.|
  Fly  1254 PVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNSDRYLS 1318

  Fly   829 -------------------------------------------------------------ITGA 832
                                                                         :.|.
  Fly  1319 YPPMEYPAALDFTAQPMPMAHLQPMTVTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVGV 1383

  Fly   833 -RPTSTFHQLTFPQGRVNVGGHNPAQPLHGHAPSPSQAS--------NSSMASSTNTLPQPHPHG 888
             :|..|.|..|       ||| :|.|.||...|....||        |.|:.::|.|||: .|||
  Fly  1384 PQPDVTHHTST-------VGG-SPMQMLHDLHPVNLSASTLTTSTTLNGSLPTATATLPR-QPHG 1439

Fly 889 888
Fly 1440 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	19/107 (18%)
		V-set	32..134	CDD:284989	19/107 (18%)
		IGc2	160..>214	CDD:197706	17/59 (29%)
		Ig	262..328	CDD:299845	18/68 (26%)
		IG_like	264..323	CDD:214653	16/61 (26%)
		IGc2	360..425	CDD:197706	14/64 (22%)
		Ig_3	456..519	CDD:290638	25/163 (15%)
		FN3	538..620	CDD:238020	19/86 (22%)
		FAM176	643..741	CDD:291517	19/132 (14%)
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	2/3 (67%)
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845	20/98 (20%)
		IG_like	490..573	CDD:214653	22/86 (26%)
		Ig	501..560	CDD:299845	17/61 (28%)
		Ig	584..666	CDD:299845	20/82 (24%)
		IG_like	585..666	CDD:214653	20/81 (25%)
		I-set	678..767	CDD:254352	20/95 (21%)
		IGc2	692..757	CDD:197706	14/64 (22%)
		Ig	788..849	CDD:143165	10/60 (17%)
		Ig	885..960	CDD:143165	10/76 (13%)
		FN3	967..1051	CDD:238020	19/85 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810