DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VII and side

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	273/984 - (27%)
Similarity:	411/984 - (41%)	Gaps:	188/984 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFMLALQLI-------ESSIGSKDVPIHQIESIVGENIYLPCNVTTYDGDEPV-LVLWYRDDKG 61
            |:.:..||.:       ||....|::|...:.:.:|:.:.|||::|.....:.| |:||::|..|
  Fly    70 LVLLTCLQQLKSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLWFKDTTG 134

  Fly    62 TPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEP--GKLSIQNTQASDSGTYRCRVDFLKAQ 124
            .|:||:|.|.|..|.....:..|..|.|.:|.....|  .:|.|.:.:..|.|.|||||||..:.
  Fly   135 IPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRVDFFNSP 199

  Fly   125 TINSRIRLNVISPPKQVIIRDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIP 189
            |.|.|..|.::.||::..|.|:...|.|.:.||:.||..:.|.|||.||.|.|.::|:||..|:
  Fly   200 TRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFREGYELFLCCQVRGGRPPPKVTWWRDDTEL- 263

  Fly   190 CELSHLA---GGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLG 251
            ...||.:   |..::..::.:.:..|:....|:.|||........|...|.:.:...|:.:::..
  Fly   264 IGTSHTSVEEGATVMVNQLLIGTTTRDFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIAT 328

  Fly   252 AHQPLSAGRRYDLLCQSAGSRPPAVITWWQNG--IR-LEKTTETTSSDGNQTTSTLSISLSKSDA 313
            .::.|:||:...:.|:|.||.|.|.|||..:|  || .|.|..:...|||.|||.|::.::..:.
  Fly   329 PNELLTAGQPMPIRCESWGSYPAAKITWLLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSEND 393

  Fly   314 GKYLSCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPS---TLREGTDVYFDCLVMAHPN 375
            ...|:|:|.|.......:||...:.:.|.|...|.|... |||   |..||.:|.|.|...|.|.
  Fly   394 NAELTCRATNPWFSGGAIEDKRIIRVAYPPTVSVHLANE-DPSRLVTRAEGQNVTFKCRADARPP 457

  Fly   376 VFRIEWRHNEQPLSHNISLGVIISNHSLVLQGVT---RATAGNYSCVGFNAEGEGISAPFALNIL 437
            |....|..|          |:.:|..|..:..:|   |.:||.|:|...|.|||..|:...|.:.
  Fly   458 VTSYSWFKN----------GMRMSGESTEIMHLTQLERESAGAYACGATNTEGETRSSSLTLKVQ 512

  Fly   438 YAPTCAQNQKKV-YGIAKQEDAKVMCTVDANPRE-VEFSWTFNNSAESIDVATNHIIRSGTTSIV 500
            ::|.|....::. .|........|.|.|||:|.: |.||||:||:.....|..:.|..:|..|.|
  Fly   513 FSPRCKSGTEQTSIGAVSLHSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTV 577

  Fly   501 TYTPITELDYGTLLCLASNKIGKQRVPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGG 565
            ||.|.|:.:..||.|.|||.:|:|..||:.||:.|..||....|.:.|  .|.|.|.|..|.:||
  Fly   578 TYLPQTDSELITLACWASNAVGRQTTPCLVHILPANTPEAPKACELRN--DTVLEVVCVAGSDGG 640

  Fly   566 LPQSFNLELL----------------------------DSYTQEIKANITS--------TIPKFT 594
            |.|.|.||::                            |:....:....||        ..|:|.
  Fly   641 LSQYFMLEVVGGDPLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSAPIFRMQENSPQFR 705

  Fly   595 VPGLSPGSIYRLNIYAFNTKGRSDPAIV-----NAAMLRMPEKQLTSEQ------THN------- 641
            :..|.||..|:..:||.|.||||:|.:|     .||.|...::.:.||.      ||:
  Fly   706 LNNLEPGREYQFLVYAVNAKGRSEPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGGVGG 770

  Fly   642 --------LRAELLFSPVMSLTIGLTLAVL----VAVLAIILA-LRIPCTASSRRRQKELSNENI 693
                    ..|.....|....|:.:..||:    |.|.:||:| :.:.|    |.|.:....:.:
  Fly   771 SGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTSIIVAGIVVVC----RHRPRPPEPQEV 831

  Fly   694 SRDESPGPSDKSSGSKEVDDCDEKNPDVVPESIEPDEQAESIRKRQQISTIDTNRSPNRGIFVNE 758
            .:...|..:|..|...|.|:.:|..        |...:|..||.|.        ..||
  Fly   832 RKSMRPARNDVPSMYIEEDELNELE--------EGGGRAADIRARV--------APPN------- 873

  Fly   759 QQHLTAAEISLRASHGIGYCTLRSGMHAQAQSSVGEISINVTPHVY-SNSISQCTLPRQSSQNVW 822
             .||.          |.|...:..|:.:...:.||...    ||.| |.|..|...|..:...:
  Fly   874 -SHLC----------GGGGMPMPGGVGSSGGAIVGVAG----PHHYISESFIQYAQPSLNGDVL- 922

  Fly   823 NNYNCNITGARPTSTFHQLTFPQGRVNVGGHNPAQPLHGHAPSPSQASNSSMASSTNTLPQ---- 883
              ....:|.::|.||                                 ||:::|....:||
  Fly   923 --LPLLVTSSQPCST---------------------------------NSTISSVVLAMPQAKLC 952

  Fly   884 PHPHGRTIA 892
            |.|..|..|
  Fly   953 PDPASRNTA 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	38/104 (37%)
		V-set	32..134	CDD:284989	38/104 (37%)
		IGc2	160..>214	CDD:197706	18/56 (32%)
		Ig	262..328	CDD:299845	25/68 (37%)
		IG_like	264..323	CDD:214653	24/61 (39%)
		IGc2	360..425	CDD:197706	20/67 (30%)
		Ig_3	456..519	CDD:290638	26/63 (41%)
		FN3	538..620	CDD:238020	32/117 (27%)
		FAM176	643..741	CDD:291517	24/102 (24%)
side	NP_001247334.1	V-set	95..211	CDD:284989	39/115 (34%)
		IG_like	100..211	CDD:214653	38/110 (35%)
		Ig	235..301	CDD:299845	21/66 (32%)
		Ig	326..408	CDD:299845	28/81 (35%)
		IG_like	329..407	CDD:214653	28/77 (36%)
		IG_like	435..511	CDD:214653	27/85 (32%)
		Ig_2	442..511	CDD:290606	25/78 (32%)
		FN3	<700..735	CDD:238020	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470113
Domainoid	1	1.000	43	1.000	Domainoid score	I12361
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23448at33392
OrthoFinder	1	1.000	-	-		FOG0002810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	8	7.850