DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VII and rst

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	200/969 - (20%)
Similarity:	337/969 - (34%)	Gaps:	297/969 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELLLLFMLALQLIESSIGSKDVPIHQIE-----SIVGENIYLPCNVTTYDGDEPVLVLWYRDDK 60
            |:||||..:...:..|...|.......:|     ::||..:.|||.|....|    .:.|.:||.
  Fly     5 MQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQG----TLQWTKDDF 65

  Fly    61 GTPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPG--KLSIQNTQASDSGTYRCRVDFLKA 123
            |         .|.|:      |.|.| :|...:...|.|  .|.|......|...|:|:|.
  Fly    66 G---------LGTSR------DLSGF-ERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVS---- 110

  Fly   124 QTINSRIRLNVISPPKQVIIRDSSNVERSTVVGP-----YSEGDI--------VSLKCQVIGGYP 175
                       ..|..|..||  |.....||:.|     .::||:        |.::|..:||.|
  Fly   111 -----------PGPEGQPAIR--STFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKP 162

  Fly   176 TPTISWYRDGIEIPCELSHLAGGKIIECEITLPSLGR-------------EDLNSRLTCRALSHP 227
            ...|:|. ||      |.::....|....|.||...|             |..|:..:|:|.:..
  Fly   163 AAEITWI-DG------LGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTA 220

  Fly   228 RAPIVEAVVQIDMNFAP-LNIRLLGAHQPLSAGRRY-----DLLCQSAGSRPPAVITWWQNGIRL 286
            ......|.:::::.:|| :.:.::|: .|..||...     ..:..|.|||   ::...|  :||
  Fly   221 DRTYRSAKIRVEVKYAPKVKVNVMGS-LPGGAGGSVGGAGGGSVHMSTGSR---IVEHSQ--VRL 279

  Fly   287 EKTTETTSSD-------------GNQTTSTLSISLSKSDAGKYLSCKAYNHAVPSEPLEDGWKLD 338
            |...:...||             |.|.|..:..::::......:.|:..|....|   ||...||
  Fly   280 ECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKS---EDSETLD 341

  Fly   339 IQYVPEAYVRLGTSLDPSTLRE--GTDVYFDCLVMAHPNVFRIEW-RH-NEQPLSHNISLGVIIS 399
            |.|.|....|      |.::..  |:.|...|.|.::|.. .|.| :| :::.:..:.:|...:|
  Fly   342 ISYAPSFRQR------PQSMEADVGSVVSLTCEVDSNPQP-EIVWIQHPSDRVVGTSTNLTFSVS 399

  Fly   400 NHSLVLQGVTRATAGNYSCVGFNAEGEG-ISAPFALNILYAPTCAQNQKKVYGIAKQEDAKVMCT 463
            |.          |||.|.|.. |..|.. |||...:.:..:|... :|:..||:. .:.|::.|.
  Fly   400 NE----------TAGRYYCKA-NVPGYAEISADAYVYLKGSPAIG-SQRTQYGLV-GDTARIECF 451

  Fly   464 VDANPREVEFSWTFNNSAESIDVATNHIIRSGTTSIVTYTPITELDYGTLLCLASNKIGKQRVPC 528
            ..:.||....|||||  .:.|...:.|                  ||..|:         ..||
  Fly   452 ASSVPRARHVSWTFN--GQEISSESGH------------------DYSILV---------DAVP- 486

  Fly   529 VFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITSTIPKF 593
                              ..:..| |.:..|..::.|   .:|..:::.|..::
  Fly   487 ------------------GGVKST-LIIRDSQAYHYG---KYNCTVVNDYGNDV----------- 518

  Fly   594 TVPGLSPGSIYRLNIYAFNTKGRSDPAIVNAAMLRMPEKQLTSEQTHNLRAELLFSPVMSLTIGL 658
                                                .|.||.::::.:|        :|::..|:
  Fly   519 ------------------------------------AEIQLQAKKSVSL--------LMTIVGGI 539

  Fly   659 TLAVLVAVLAIILALRIPCTASSRRRQK-----ELSNENISRDESPG----PSDKSSGSKEVDDC 714
            ::...:.||.|::.:.|.|    ::|.|     .:|...|:::....    |.|::|...::
  Fly   540 SVVAFLLVLTILVVVYIKC----KKRTKLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDL--- 597

  Fly   715 DEKNPDV----VPESIEPDEQAESIRKRQQISTIDTNRSPNRGIFVNEQQHLTAAEISLRASH-- 773
               ..|:    ||..   |.........|.::|..|..:.:..|..|..|:....:...:.||
  Fly   598 ---KVDISGGYVPYG---DYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQ 656

  Fly   774 --------GIGYCTLRSGMHAQAQSSVGEISI---NVTPHVYSNSIS-QCTLPRQSSQNVWNNYN 826
                    .:.:.|..|| .:...|.:|...|   |..|.:.|.:.| ..:.|..|..|
  Fly   657 HHTQTTTLPMTFLTNSSG-GSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNGSCSN------ 714

  Fly   827 CNITGARPTSTFHQLTFPQGRVNVGGHNPAQPLHGHAPSP-SQASNSSMASSTNTLPQP 884
             ..|.|..|:|.|.:......::|.....|  ::|   :| .::||||:      ||.|
  Fly   715 -QSTTAATTTTTHVVVPSSMALSVDPRYSA--IYG---NPYLRSSNSSL------LPPP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	25/103 (24%)
		V-set	32..134	CDD:284989	25/103 (24%)
		IGc2	160..>214	CDD:197706	17/74 (23%)
		Ig	262..328	CDD:299845	15/83 (18%)
		IG_like	264..323	CDD:214653	14/71 (20%)
		IGc2	360..425	CDD:197706	17/68 (25%)
		Ig_3	456..519	CDD:290638	14/62 (23%)
		FN3	538..620	CDD:238020	6/81 (7%)
		FAM176	643..741	CDD:291517	19/110 (17%)
rst	NP_001284835.1	IG_like	34..130	CDD:214653	32/132 (24%)
		Ig	42..114	CDD:299845	24/106 (23%)
		C2-set_2	135..225	CDD:285423	21/96 (22%)
		Ig_3	265..329	CDD:290638	14/68 (21%)
		I-set	346..420	CDD:254352	22/91 (24%)
		Ig	360..425	CDD:299845	21/76 (28%)
		Ig5_KIRREL3-like	428..524	CDD:143235	28/196 (14%)
		IG_like	435..524	CDD:214653	27/188 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910