DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VII and syg-2

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	1107	Identity:	236/1107 - (21%)
Similarity:	372/1107 - (33%)	Gaps:	413/1107 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GENIYLPCNVTTYDGDEPVLVLWYRDDKGTP--------------IYSI-----------DIRAG 72
            |:|:.:.|:||  .|:.|..|.||.::|...              |||.           :.||.
Worm   249 GDNVTIACSVT--GGNPPPDVFWYHENKRLQSHSTLDTRSKEIKNIYSFIASQNDNMAEYECRAN 311

  Fly    73 VSKA--PKR--------WSDDSV--FGDR-----------------------AYFI--------- 93
            .|:.  |||        :...||  ||:.                       .:.|
Worm   312 NSRTGNPKRKAMKLEVNYPPASVELFGESNIRYGSSANIQCKSLPSNPASQITWIINGRSVPTPT 376

  Fly    94 ---FDKEPGKLSIQNTQASDS----GTYRCRVDFLKAQTINSRIR---LNVISPPKQVIIRDSSN 148
               |..|.|.:|..|.....:    ..::..|:.:......|..:   :.:|:|||..||....:
Worm   377 QREFVVENGIVSSSNVSVHSNELSVEAHQINVECMATNPEGSSAKQHVIKIIAPPKAPIITGLED 441

  Fly   149 VERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIPCELSHLAGG--KIIECEI------ 205
            .:       :.|||||::.|:..||.|...:|||| |.|     .||..|  |:...::
Worm   442 RK-------FFEGDIVNVTCEAQGGNPLAELSWYR-GSE-----KHLVKGRKKMKWSQVNGAHNE 493

  Fly   206 --------TLPSLGREDLNS-RLTCRALSHPRAPIVEAVVQ---IDMNFAPLNIRLLGA---HQP 255
                    ||.......:|: ||.|.|.:   |.:.|.:::   :.:.:.|..:.:..|   .|.
Worm   494 VAGFSSYSTLALRVDRTMNTQRLKCEATN---AALDEPLIESQYLSVYYPPRRVLIRPADSGDQR 555

  Fly   256 LSAGRRYDLLCQSAGSRPPAVITWW------QNGIRLEKTT--ETTSSDGNQTTSTLSISLSKSD 312
            |..|:...|:|.:..|.|.|.|:|.      .|.:.|...:  |||..:|....:.||.:.::..
Worm   556 LLVGKSARLVCGTLSSNPAAHISWQFSRATDDNKVHLGDVSLNETTRDNGFNVENVLSFTPTEEY 620

  Fly   313 AGKYLSCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPST--LREGTDVYFDCLVMAHPN 375
            .|..:.|.| ||......:...:.|::.|.|:..|.     ||.|  :.||.....:..|..:|.
Worm   621 DGTVVHCIA-NHPEWKHSVNTSFPLNVMYPPKMLVN-----DPVTVVMSEGDSFKENLTVRGNPA 679

  Fly   376 VFRIEWRHNEQPLSHNI----SLGVIISNHSLVL--QGVTRATA--------------------- 413
            :...:||.|..|..|.|    :.|.::|...|:.  .||...||
Worm   680 ISLWQWRKNGVPFDHTIGRVFARGAVLSGKQLLSTDAGVYTLTATNSVGSTNITIKLAVEYSARI 744

  Fly   414 -------------------------------------------------------------GNYS 417
                                                                         |.|:
Worm   745 TSISTPVIAATGDTVLLECEADGEPSKANMIHWYKNGEILAAQHRGHKKAILRLNATEQQSGEYT 809

  Fly   418 C-----VGFNAEGEGI----SAPFALNIL-YAPTCAQNQKKVYGIAKQEDAKVMCTVDANPREVE 472
            |     :|..|||:..    |||..|.:. ||.|..     :.|..    ||..|.|.|.| .||
Worm   810 CKADNGIGVPAEGQTFLLVNSAPRVLPVARYAKTAG-----ILGGV----AKARCKVYAVP-TVE 864

  Fly   473 FSWTFNNSAESIDVATNHIIRSGTT--SIVTYTPITELDYGT------------------LLCLA 517
            |.|.          ....:|:..::  |||.    |::||.|                  :.|:|
Worm   865 FVWE----------KDEQLIKKNSSKYSIVN----TQIDYSTYESTLWIKNIVPDDYTKKVKCIA 915

  Fly   518 SNKIGKQR--VPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQ 580
            .|..|...  :|    ||....|::..|.|:.|.::.:::|.....|:||..|.|.:: ......
Worm   916 RNSFGTDHLSIP----IIPPTHPDEPFNLTMTNSTLNTISVAWEPRFDGGSDQIFEVK-YRRQND 975

  Fly   581 EIKANITSTIPKFTVPGLSPGSIYRLNIYAFNTKG----RSDPAI--------VNAAMLRMPEKQ 633
            ::...:.:|.....:.||:..:.|...|.:.|.:|    .:.|.|        ||.||:|..:.:
Worm   976 DLIHLVNTTHTNLRLSGLATANTYFFQIRSINARGFASSWTSPVIFATLNEDGVNVAMIRNEKLK 1040

  Fly   634 LTSEQTHNLRAELLFSPVMSLTIGLTLAVLVAVLAIILALRIPCTASSRRRQKE----------- 687
            ||:           :.|.:.:.|.|.:.:.|.:...:      |..:.:|:.:|
Worm  1041 LTT-----------WIPYILIFIVLFMLLNVVICCFV------CNRTKKRKLREKTEMARTAING 1088

  Fly   688 ------------LSNENISRDESPGPSDKSSGSKEVDDCDEKNPDVVPESIEPDEQAESIRKRQQ 740
                        :.|:.:||             :::||..|.:           |...|:|...:
Worm  1089 GDVRQVQMYGTMMGNDGMSR-------------RDIDDRPEMS-----------EDEHSVRTMIE 1129

  Fly   741 ISTIDTNRSPNRGIFVNEQQHLTAAEISLRASHGI---GYCTLRSGMHAQAQSSVGEISI---NV 799
            :       |||        .::...|..|..|.|:   .|.| ||.|    .||.|..|:   ||
Worm  1130 V-------SPN--------GYMQPIEPMLYESTGLLEYDYQT-RSYM----GSSQGTRSMTYANV 1174

  Fly   800 ------TPHVYSNSISQCTLPRQSSQNVWNNYNCNITGARPTSTFHQL-TF--PQGRVNVGGHNP 855
                  .|..:||..|   |.|||:.|              ||..|.| ||  |...|..|..|.
Worm  1175 PYPEPPQPSYHSNWNS---LQRQSNNN--------------TSPQHHLSTFINPNMGVRAGPINY 1222

  Fly   856 AQ 857
            ||
Worm  1223 AQ 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	32/179 (18%)
		V-set	32..134	CDD:284989	32/179 (18%)
		IGc2	160..>214	CDD:197706	21/69 (30%)
		Ig	262..328	CDD:299845	20/73 (27%)
		IG_like	264..323	CDD:214653	18/66 (27%)
		IGc2	360..425	CDD:197706	22/157 (14%)
		Ig_3	456..519	CDD:290638	20/82 (24%)
		FN3	538..620	CDD:238020	17/85 (20%)
		FAM176	643..741	CDD:291517	16/120 (13%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653
		Ig	33..122	CDD:299845
		Ig	147..228	CDD:299845
		IGc2	248..313	CDD:197706	16/65 (25%)
		Ig	450..537	CDD:299845	24/95 (25%)
		Ig	559..632	CDD:299845	20/73 (27%)
		I-set	657..738	CDD:254352	19/80 (24%)
		Ig	665..738	CDD:299845	16/72 (22%)
		IG_like	748..828	CDD:214653	7/79 (9%)
		IGc2	756..817	CDD:197706	3/60 (5%)
		Ig	845..922	CDD:299845	23/100 (23%)
		FN3	934..1023	CDD:238020	19/89 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810