DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VII and FCRL1

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_443170.1	Gene:	FCRL1 / 115350	HGNCID:	18509	Length:	429	Species:	Homo sapiens

Alignment Length:	544	Identity:	116/544 - (21%)
Similarity:	188/544 - (34%)	Gaps:	161/544 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFMLALQLIESS----IGSKDVPIHQIESIVGENIYLPCNVT-TYDGDEPVLVLWYRDDKGTPI 64
            ||.::...|.|.:    |.|   |.|..|   |..:.|.|.:. ....|......::||.:.
Human     5 LLLLICAPLCEPAELFLIAS---PSHPTE---GSPVTLTCKMPFLQSSDAQFQFCFFRDTRA--- 60

  Fly    65 YSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVDFLKAQTINS- 128
                :..|.|.:|                      ||.|......|:|:|.|....:.::.:.|
Human    61 ----LGPGWSSSP----------------------KLQIAAMWKEDTGSYWCEAQTMASKVLRSR 99

  Fly   129 RIRLNVISPPKQVIIRDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRD--GIEIPCE 191
            |.::||    .:|.:.|.| :|.....|...|||.:.|.|.|..|....|..||:.  |:.:..:
Human   100 RSQINV----HRVPVADVS-LETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSK 159

  Fly   192 LSHLAGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPL 256
            ..     :.:..|..:||: ||....:..|.| .:...|....:|.|.:.. |::..:|....|.
Human   160 TQ-----RSLTAEYEIPSV-RESDAEQYYCVA-ENGYGPSPSGLVSITVRI-PVSRPILMLRAPR 216

  Fly   257 SAGRRYDLL---CQSAGSRPPAVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLS 318
            :.....|:|   |::....||.:..::...|.|  .:.:..|.|.   ::.::||::..:|.| |
Human   217 AQAAVEDVLELHCEALRGSPPILYWFYHEDITL--GSRSAPSGGG---ASFNLSLTEEHSGNY-S 275

  Fly   319 CKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEWRH 383
            |:|.|                        .||..                             |.
Human   276 CEANN------------------------GLGAQ-----------------------------RS 287

  Fly   384 NEQPLSHNISLGVIISNH--SLVLQGVTR----ATAGNYSCVGFNAEGEGISA-----------P 431
            ....|:..:..|. .|||  |.|::|:..    ||.....|.|...:....||           |
Human   288 EAVTLNFTVPTGA-RSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLP 351

  Fly   432 FALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANPREVEFSWTFNNSAESIDVATNHIIRSGT 496
            .....|.:||..|.| .:|     |:..|:     :..|| :|..:.|..|...||...:   ||
Human   352 QEFTYLNSPTPGQLQ-PIY-----ENVNVV-----SGDEV-YSLAYYNQPEQESVAAETL---GT 401

  Fly   497 -----TSIVTYT-----PITELDY 510
                 .|:..|:     .||::||
Human   402 HMEDKVSLDIYSRLRKANITDVDY 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	18/103 (17%)
		V-set	32..134	CDD:284989	18/103 (17%)
		IGc2	160..>214	CDD:197706	15/55 (27%)
		Ig	262..328	CDD:299845	17/68 (25%)
		IG_like	264..323	CDD:214653	15/61 (25%)
		IGc2	360..425	CDD:197706	13/70 (19%)
		Ig_3	456..519	CDD:290638	17/65 (26%)
		FN3	538..620	CDD:238020
		FAM176	643..741	CDD:291517
FCRL1	NP_443170.1	Ig_2	19..90	CDD:316418	21/105 (20%)
		IG_like	119..201	CDD:214653	22/88 (25%)
		Ig_3	207..280	CDD:316449	18/78 (23%)
		ITIM motif 1	354..359		1/4 (25%)
		ITIM motif 2	367..372		2/9 (22%)
		ITIM motif 3	379..384		3/5 (60%)
		ITIM motif 4	410..415		1/4 (25%)
		ITIM motif 5	423..428		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000