DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VII and BTN3A1

DIOPT Version :9

Sequence 1:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens

Alignment Length:	422	Identity:	89/422 - (21%)
Similarity:	138/422 - (32%)	Gaps:	150/422 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLFMLALQLIE---------SSIGSKDVPIHQIESIVGENIYLPCNVTTYDGDEPVLVLW--- 55
            |||.|.:.|.|::         |.:|    |...|.::|||:..|||::......|.:.:.|
Human    10 LLLNFRVCLLLLQLLMPHSAQFSVLG----PSGPILAMVGEDADLPCHLFPTMSAETMELKWVSS 70

  Fly    56 --------YRDDKGTPIYSIDIRAGVSKAPKRWSD----DSVFGDRAYFIFDKEPGKLSIQNTQA 108
                    |.|.|     .::.|   ..||.|...    |.:...:|         .|.|.|..|
Human    71 SLRQVVNVYADGK-----EVEDR---QSAPYRGRTSILRDGITAGKA---------ALRIHNVTA 118

  Fly   109 SDSGTYRCRV---DF-------LKAQTINSRIRLNVISPPKQVIIRDSSNVERSTVVGPYSEGDI 163
            ||||.|.|..   ||       ||...:.|.:.::|..                     |.:|.|
Human   119 SDSGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKG---------------------YKDGGI 162

  Fly   164 VSLKCQVIGGYPTPTISW---------------YRDGIEIPCELSHL----AGGKIIECEITLPS 209
             .|:|:..|.||.|.|.|               ..||:.:....:.:    :.|:.:.|.|....
Human   163 -HLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSL 226

  Fly   210 LGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPLSAGRRYDLLCQSAGSRPP 274
            ||.|    :....:::.|.....:..:.......|:.:.|||       |..|.|
Human   227 LGLE----KTASISIADPFFRSAQRWIAALAGTLPVLLLLLG-------GAGYFL---------- 270

  Fly   275 AVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAG--------------KYLSCKAYNHA 325
                 ||.  :.||.|:.......|....::.|..|.:..              :|.| :...|:
Human   271 -----WQQ--QEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYAS-RGERHS 327

  Fly   326 VPSEPLEDGWKLDIQYVPEAYVRLGTSLDPST 357
            ..:|     ||..: :.|...:     |||.|
Human   328 AYNE-----WKKAL-FKPADVI-----LDPKT 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	32/126 (25%)
		V-set	32..134	CDD:284989	32/126 (25%)
		IGc2	160..>214	CDD:197706	17/72 (24%)
		Ig	262..328	CDD:299845	13/79 (16%)
		IG_like	264..323	CDD:214653	11/72 (15%)
		IGc2	360..425	CDD:197706
		Ig_3	456..519	CDD:290638
		FN3	538..620	CDD:238020
		FAM176	643..741	CDD:291517
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	31/122 (25%)
		Ig_MOG_like	45..144	CDD:143190	30/115 (26%)
		SPRY_PRY_BTN3	337..512	CDD:293992	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000