Protein Alignment side-VII and MERTK

DIOPT Version :9

• Sequence 1: NP_001262432.1
• Gene: side-VII / 41184
• FlyBaseID: FBgn0037736
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_006334.2
• Gene: MERTK / 10461
• HGNCID: 7027
• Length: 999
• Species: Homo sapiens
• Alignment Length: 1002
• Identity: 182/1002 - (18%)
• Similarity: 308/1002 - (30%)
• Gaps: 393/1002 - (39%)

  Fly    16 SSIGSKDVPIHQIESIVG-------ENIYLPCNVTTYDGDEPVLVLWYRDDKGTPIYSIDIRAGV 73
            :|:.||.:|....:..||       :.:...|:::..:..:...:.|::|.|       ::....
Human    84 TSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGK-------ELLGAH 141

  Fly    74 SKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVDFLKAQTINSRIRLNVISPP 138
            ....:.:.||.|....|.|         ||.:.|.||:|:|.|::.....:.::..|.:.|...|
Human   142 HAITQFYPDDEVTAIIASF---------SITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLP 197

  Fly   139 KQVIIRDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEI-------PCELSHLA 196
            ......:|.||.|:|.         .:|.||.:|......|.|.::...:       |..|
Human   198 HFTKQPESMNVTRNTA---------FNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVL---- 249

  Fly   197 GGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAP-----LNIRLLGAH--- 253
                     |:|.|....:   .:|.| .:.:...|...|||::...|     ::||...||
Human   250 ---------TVPGLTEMAV---FSCEA-HNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSIL 301

  Fly   254 -----------------------QPLSAG----------------------RRYDL--------- 264
                                   .|||.|                      ..|.:
Human   302 ISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIG 366

  Fly   265 -------LCQSAGSRPPAV-----------------ITW--------------------WQN-GI 284
                   :..|.....|:|                 |.|                    ||: ||
Human   367 WSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGI 431

  Fly   285 RLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLSCKAYNHAVP-------SEPLE-----DGWKL 337
            ..|...|.     .|..|...||:...:|    :|.....||.       |:|::     .||
Human   432 SKELLEEV-----GQNGSRARISVQVHNA----TCTVRIAAVTRGGVGPFSDPVKIFIPAHGW-- 485

  Fly   338 DIQYVPEAYVRLGTSLDPSTLREGTDVYFDC--------LVM---------AHPNVFRIEWRHNE 385
             :.|.|.:....|.: ||..      :.|.|        |::         .....|...:...:
Human   486 -VDYAPSSTPAPGNA-DPVL------IIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEED 542

  Fly   386 QPLSHNI----------------SLG-----------VIISNHSLVLQGVTRATAGNYSCVGFNA 423
            ..|..|.                |||           |:|..:.|:|..:.             .
Human   543 SELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKIL-------------G 594

  Fly   424 EGEGISAPFALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANPREVEFSWTFNNSAESI-DVA 487
            |||           :......|.|:..|.:.:...|.|...:::.||:|   .|.:.|..: |.:
Human   595 EGE-----------FGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIE---EFLSEAACMKDFS 645

  Fly   488 TNHIIR----------SGTTSIVTYTPITELDYG---TLLCLASNKIGKQRVP----CVFHI-IA 534
            ..::||          .|....:...|.  :.||   |.|..:..:.|.:.:|    ..|.: ||
Human   646 HPNVIRLLGVCIEMSSQGIPKPMVILPF--MKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 708

  Fly   535 AG-----------RPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITS 588
            .|           |.....||.:.:    .:||..:|   .||  |..:...|.|.|       .
Human   709 LGMEYLSNRNFLHRDLAARNCMLRD----DMTVCVAD---FGL--SKKIYSGDYYRQ-------G 757

  Fly   589 TIPKFTVPGLSPGS----IY--RLNIYAFN-------TKGRSD-PAIVNAAM---------LRMP 630
            .|.|..|..::..|    :|  :.:::||.       |:|.:. |.:.|..|         |:.|
Human   758 RIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQP 822

  Fly   631 EKQLTSEQTHNL-----RAELLFSPVMSLTIGLTLAVLVAVLAIILALRIPCTASSRRRQKEL-- 688
            |..|  ::.:.:     |.:.|..|..|: :.|.|..|:..|..:            |.|.::
Human   823 EDCL--DELYEIMYSCWRTDPLDRPTFSV-LRLQLEKLLESLPDV------------RNQADVIY 872

  Fly   689 -------SNENISRDESPGPSDKSSGSKEVDDCDEKNPDVVPESIEPDEQAESIRKRQQISTIDT 746
                   |:|.:::..:..|.|.                    :|:||....|...|..||.:..
Human   873 VNTQLLESSEGLAQGSTLAPLDL--------------------NIDPDSIIASCTPRAAISVVTA 917

  Fly   747 ---NRSPNRGIFV-----NEQQHLTAA 765
               :..|:.|.::     .|.:.||:|
Human   918 EVHDSKPHEGRYILNGGSEEWEDLTSA 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	20/108 (19%)
		V-set	32..134	CDD:284989	20/108 (19%)
		IGc2	160..>214	CDD:197706	11/60 (18%)
		Ig	262..328	CDD:299845	20/126 (16%)
		IG_like	264..323	CDD:214653	17/112 (15%)
		IGc2	360..425	CDD:197706	13/108 (12%)
		Ig_3	456..519	CDD:290638	16/76 (21%)
		FN3	538..620	CDD:238020	20/95 (21%)
		FAM176	643..741	CDD:291517	19/106 (18%)
MERTK	NP_006334.2	IG	111..193	CDD:214652	18/97 (19%)
		Ig	111..176	CDD:143165	16/80 (20%)
		Ig2_Tyro3_like	199..279	CDD:143226	21/105 (20%)
		IG_like	203..280	CDD:214653	22/102 (22%)
		FN3	284..378	CDD:238020	10/93 (11%)
		FN3	386..478	CDD:238020	18/100 (18%)
		PTKc_Mer	579..862	CDD:271106	67/330 (20%)
		Pkinase_Tyr	587..854	CDD:285015	63/314 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000