Protein Alignment alphaTub85E and TUBB6

DIOPT Version :9

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001290453.1
• Gene: TUBB6 / 84617
• HGNCID: 20776
• Length: 446
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 185/452 - (40%)
• Similarity: 272/452 - (60%)
• Gaps: 15/452 - (3%)

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGDDSFSTFFSETGAGKHVPRA 65
            |||.:.:..||.|.|||...||:...||||.|.|....|..:  ..:..:.:::|:.:.|:||||
Human     1 MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSAL--QLERINVYYNESSSQKYVPRA 63

  Fly    66 VFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQCT 130
            ..|||||..:|.||:|.:.|||.|:..|.|:..|.||:|:||||.|.|:||.|||.:||..:.|.
Human    64 ALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVVRKECEHCD 128

  Fly   131 GLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTL 195
            .||||.:.||.|||||||..:||:.::..::..:....||:.|:|:||..||||||:.|:.|..:
Human   129 CLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLV 193

  Fly   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV 260
            |::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|.||||.|.||.||.:...|:|
Human   194 ENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMV 258

  Fly   261 PYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLYRGDVVP 325
            |:||:||.:..:||:.|.....:..|||.|:|...|:..|.|..||||.|:|:....::||.:..
Human   259 PFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMMAACDPRHGRYLTVATVFRGPMSM 323

  Fly   326 KDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390
            |:|:..:..|::|.|..||:|.|...||.:...||        ..::.|...:.|:|||.|.:.|
Human   324 KEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPP--------RGLKMASTFIGNSTAIQELFKR 380

  Fly   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELG----EDEE 448
            :..:|..|:.::||:||:.||||:|.||.||..::..|..:|::.. |:|...|    ||||
Human   381 ISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQ-DATANDGEEAFEDEE 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	183/450 (41%)
TUBB6	NP_001290453.1	PLN00220	1..432	CDD:215107	180/441 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810