DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub85E and TUBAL3

DIOPT Version :9

Sequence 1:	NP_524297.1	Gene:	alphaTub85E / 41183	FlyBaseID:	FBgn0003886	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_079079.1	Gene:	TUBAL3 / 79861	HGNCID:	23534	Length:	446	Species:	Homo sapiens

Alignment Length:	446	Identity:	324/446 - (72%)
Similarity:	387/446 - (86%)	Gaps:	15/446 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDG-----------HMPSDKTVGGGDDSFSTFFS 54
            ||||:|:||||||:|||:||||||||||||||:|           :...:.|    :.||.|||.
Human     1 MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQLENAKMEHT----NASFDTFFC 61

  Fly    55 ETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVL 119
            ||.||||||||:||||||||:|.:|||.:|.|||||||::||||||||||||.|::|.|::|:||
Human    62 ETRAGKHVPRALFVDLEPTVIDGIRTGQHRSLFHPEQLLSGKEDAANNYARGRYSVGSEVIDLVL 126

  Fly   120 DRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEP 184
            :|.||||:||.||||||:|.||||||||||||||||||:.:|.:|:|||||:||||::|||||||
Human   127 ERTRKLAEQCGGLQGFLIFRSFGGGTGSGFTSLLMERLTGEYSRKTKLEFSVYPAPRISTAVVEP 191

  Fly   185 YNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALN 249
            |||:||||:|.||:||.|||||||:||||.|.|.:|.|::.::|||:.|:||||||||||:|.||
Human   192 YNSVLTTHSTTEHTDCTFMVDNEAVYDICHRKLGVECPSHASINRLVVQVVSSITASLRFEGPLN 256

  Fly   250 VDLTEFQTNLVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMA 314
            |||.|||||||||||||||:..:||::|.:||||||.:|::||.||||.:||:||||||.|||||
Human   257 VDLIEFQTNLVPYPRIHFPMTAFAPIVSADKAYHEQFSVSDITTACFESSNQLVKCDPRLGKYMA 321

  Fly   315 CCMLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLS 379
            ||:|||||||||:||||||..|::.|:|||||||||||||||.:||||:||||||||.|::||||
Human   322 CCLLYRGDVVPKEVNAAIAATKSRHSVQFVDWCPTGFKVGINNRPPTVMPGGDLAKVHRSICMLS 386

  Fly   380 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEV 435
            |||||.|||||||||||||||||||:|||:.|||||.||.||||||||||:|||||
Human   387 NTTAIVEAWARLDHKFDLMYAKRAFLHWYLREGMEEAEFLEAREDLAALERDYEEV 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	324/446 (73%)
TUBAL3	NP_079079.1	alpha_tubulin	2..442	CDD:276955	321/443 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54134
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730