Protein Alignment alphaTub85E and TUBG1

DIOPT Version :10

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001061.2
• Gene: TUBG1 / 7283
• HGNCID: 12417
• Length: 451
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 144/446 - (32%)
• Similarity: 238/446 - (53%)
• Gaps: 28/446 - (6%)

  Fly     2 RECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGDDSFSTFFSETGAGKHVPRAV 66
            ||.|::.:||.|.|||...|:..|.||||.|:|.:....|  .|.|....||.:.....::||||
Human     3 REIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFAT--EGTDRKDVFFYQADDEHYIPRAV 65

  Fly    67 FVDLEPTVVDEVRTGTYRQLFHPEQLITGKE--DAANNYARGHYTIGKEIVDVVLDRIRKLADQC 129
            .:||||.|:..:....|.:|::||.:...:.  .|.||:|.| ::.|::|.:.:.|.|.:.||..
Human    66 LLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASG-FSQGEKIHEDIFDIIDREADGS 129

  Fly   130 TGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYP-APQVSTAVVEPYNSILTTHT 193
            ..|:||::.||..||||||..|.|:|||:..|.||....:|::| ..::|..||:||||:||...
Human   130 DSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKR 194

  Fly   194 TLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQTN 258
            ..:::||..::||.|:..|....|.|:.|::..:|:|:..|:|:.|.:||:.|.:|.||.....:
Human   195 LTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIAS 259

  Fly   259 LVPYPRIHF------PLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGK---YMA 314
            |:|.||:||      ||.|...|.||.|.     ||.::.....:|.|.||.....|..   |:|
Human   260 LIPTPRLHFLMTGYTPLTTDQSVASVRKT-----TVLDVMRRLLQPKNVMVSTGRDRQTNHCYIA 319

  Fly   315 CCMLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLS 379
            ...:.:|:|.|..|:.::..|:.::...|:.|.|...:|.::.:.|.:.....::.:     |::
Human   320 ILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGL-----MMA 379

  Fly   380 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAE---AREDLAALEKDY 432
            |.|:|:..:.|...::|.:..:.||:..:..|.|.:..|.|   :||.:..|..:|
Human   380 NHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDEMDTSREIVQQLIDEY 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	144/446 (32%)
TUBG1	NP_001061.2	gamma_tubulin	3..435	CDD:276957	143/444 (32%)