Protein Alignment alphaTub85E and TUBD1

DIOPT Version :10

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_057345.2
• Gene: TUBD1 / 51174
• HGNCID: 16811
• Length: 453
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 116/473 - (24%)
• Similarity: 202/473 - (42%)
• Gaps: 71/473 - (15%)

  Fly     5 ISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGDDSFST-----FFSETGAGKHVPR 64
            ::|.:||.|.|||   :|::   ..:..|.|..........::::..     ||||...|..:.|
Human     4 VTVQLGQCGNQIG---FEVF---DALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPIAR 62

  Fly    65 AVFVDLEPTVVDEV-----RTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRK 124
            ||.||:||.|::::     ::|.::  :........|:.:.||:|.|:...|....:.:::.|||
Human    63 AVLVDMEPKVINQMLSKAAQSGQWK--YGQHACFCQKQGSGNNWAYGYSVHGPRHEESIMNIIRK 125

  Fly   125 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSIL 189
            ..::|....||.:..|..||||||..:.:.:.|...|....|:...|:|. .....:|:.|||||
Human   126 EVEKCDSFSGFFIIMSMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPY-GTGEVIVQNYNSIL 189

  Fly   190 TTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSI-----TASLRFDGALN 249
            |.......||...:.:|:||:.||.:.::|::.::.::|:::...:.|:     :|...|....|
Human   190 TLSHLYRSSDALLLHENDAIHKICAKLMNIKQISFSDINQVLAHQLGSVFQPTYSAESSFHYRRN 254

  Fly   250 VDLTEFQTNLVPYPRIHFPLATYAPVISVEKAYHEQLTVAE---------ITNACFEPANQMVKC 305
             .|.:...:|||:|..........|.:|.....:...|.|.         |:||..|........
Human   255 -PLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGLLKHLRQMLISNAKMEEGIDRHVW 318

  Fly   306 DPRRGKYMACCMLYRGDVVPKDVNAAIATIKTKR--SIQFVDWCPTGFKVGINY----QPPTVVP 364
            .|..|......|....|:   ..|.:||.:...|  .:|..|  ..|||....|    :|   |.
Human   319 PPLSGLPPLSKMSLNKDL---HFNTSIANLVILRGKDVQSAD--VEGFKDPALYTSWLKP---VN 375

  Fly   365 GGDLAKVQRA-------VCMLSNT--------TAIAEAWARLDHKFDLMYAKRAFVHWYVGEGME 414
            ..::.|.|||       ..::||:        ..:.:||.        |:|.:|::|.|...|:|
Human   376 AFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWN--------MFASKAYIHQYTKFGIE 432

  Fly   415 EGEFAEAREDLAALEKDY 432
            |.:|.::...|..:...|
Human   433 EEDFLDSFTSLEQVVASY 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	116/473 (25%)
TUBD1	NP_057345.2	delta_zeta_tubulin-like	2..452	CDD:276958	116/473 (25%)