Protein Alignment alphaTub85E and TUBB8

DIOPT Version :9

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_817124.1
• Gene: TUBB8 / 347688
• HGNCID: 20773
• Length: 444
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 183/455 - (40%)
• Similarity: 269/455 - (59%)
• Gaps: 23/455 - (5%)

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQP------DGHMPSDKTVGGGDDSFSTFFSETGAG 59
            |||.:...|||.|.|||...||:...||.|..      |.|:..::        .:.:::|...|
Human     1 MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLER--------INVYYNEASGG 57

  Fly    60 KHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRK 124
            ::|||||.|||||..:|.||:|.:.|:|.|:..|.|:..|.||:|:||||.|.|:::.|:|.:||
Human    58 RYVPRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVVRK 122

  Fly   125 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSIL 189
            .|:.|..||||.:.||.|||||||..:||:.::..:|..:....|||.|:|:||..||||||:.|
Human   123 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVVEPYNATL 187

  Fly   190 TTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTE 254
            :.|..:|::|..|.:||||:||||.:.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:
Human   188 SVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRK 252

  Fly   255 FQTNLVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLY 319
            ...|:||:||:||.:..:||:.|.....:..|||||:|...|:..|.|..||||.|:|:....::
Human   253 LAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMMAACDPRHGRYLTAAAIF 317

  Fly   320 RGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAI 384
            ||.:..::|:..:..|:.|.|..|.||.|...|..:...||        ..::.:...:.|.|||
Human   318 RGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPP--------RGLKMSATFIGNNTAI 374

  Fly   385 AEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELGEDEEY 449
            .|.:.|:..:|..|:.::||:|||.||||:|.||.||..::..|..:|::.. |:|.|..|||||
Human   375 QELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQ-DATAEEEEDEEY 438

  Fly   450  449
            Human   439  438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	180/452 (40%)
TUBB8	NP_817124.1	PTZ00010	1..427	CDD:240228	175/442 (40%)
		beta_tubulin	2..426	CDD:276956	174/439 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..444		8/17 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810