DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub85E and Tubb4a

DIOPT Version :9

Sequence 1:	NP_524297.1	Gene:	alphaTub85E / 41183	FlyBaseID:	FBgn0003886	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_543158.1	Gene:	Tubb4a / 29213	RGDID:	619730	Length:	444	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	185/450 - (41%)
Similarity:	273/450 - (60%)	Gaps:	15/450 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDG--HMPSDKTVGGGDDSFSTFFSETGAGKHVP 63
            |||.:.:..||.|.|||...||:...||||.|.|  |..||..:    :..:.:::|...|.:||
  Rat     1 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQL----ERINVYYNEATGGNYVP 61

  Fly    64 RAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQ 128
            |||.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||.|:.
  Rat    62 RAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAES 126

  Fly   129 CTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHT 193
            |..||||.:.||.|||||||..:||:.::..::..:....||:.|:|:||..||||||:.|:.|.
  Rat   127 CDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQ 191

  Fly   194 TLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQTN 258
            .:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:...|
  Rat   192 LVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVN 256

  Fly   259 LVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLYRGDV 323
            :||:||:||.:..:||:.|.....:..|||.|:|...|:..|.|..||||.|:|:....::||.:
  Rat   257 MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRM 321

  Fly   324 VPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAW 388
            ..|:|:..:.::::|.|..||:|.|...|..:...||        ..::.|...:.|:|||.|.:
  Rat   322 SMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMAATFIGNSTAIQELF 378

  Fly   389 ARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELGEDEE 448
            .|:..:|..|:.::||:|||.||||:|.||.||..::..|..:|::.. |:|.|.||.||
  Rat   379 KRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQ-DATAEEGEFEE 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	183/448 (41%)
Tubb4a	NP_543158.1	PLN00220	1..427	CDD:215107	178/438 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900