Protein Alignment alphaTub85E and TUBG2

DIOPT Version :10

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001307438.1
• Gene: TUBG2 / 27175
• HGNCID: 12419
• Length: 460
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 146/463 - (31%)
• Similarity: 239/463 - (51%)
• Gaps: 45/463 - (9%)

  Fly     2 RECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGDDSFSTFFSETGAGKHVPRAV 66
            ||.|::.:||.|.|||...|:..|.||||.|:|.:....|  .|.|....||.:.....::||||
Human     3 REIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFAT--EGTDRKDVFFYQADDEHYIPRAV 65

  Fly    67 FVDLEPTVVDEVRTGTYRQLFHPEQLITGKE--DAANNYARGHYTIGKEIVDVVLDRIRKLADQC 129
            .:||||.|:..:....|.:|::||.:...:.  .|.||:|.| ::.|::|.:.:.|.|.:.||..
Human    66 LLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASG-FSQGEKIHEDIFDIIDREADGS 129

  Fly   130 TGLQ---------GFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYP-APQVSTAVVEP 184
            ..|:         ||::.||..||||||..|.|:|||:..|.||....:|::| ..::|..||:|
Human   130 DSLELQNSSRVIKGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSDVVVQP 194

  Fly   185 YNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALN 249
            |||:||.....:::||..::||.|:..|....|.|:.|::..:|:|:..|:|:.|.:||:.|.:|
Human   195 YNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMN 259

  Fly   250 VDLTEFQTNLVPYPRIHF------PLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPR 308
            .||.....:|:|.||:||      ||.|...|.||.|.     ||.::.....:|.|.||.....
Human   260 NDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKT-----TVLDVMRRLLQPKNVMVSTGRD 319

  Fly   309 RGK---YMACCMLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAK 370
            |..   |:|...:.:|:|.|..|:.::..|:.::...|:.|.|...:|.::.:.|.:.....::.
Human   320 RQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSG 384

  Fly   371 VQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAE---AREDL------- 425
            :     |::|.|:|:..:.....:||.:..:.||:..:..|.|.:..|.|   :||.:
Human   385 L-----MMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDEMDRSREVVQELIDEY 444

  Fly   426 -AALEKDY 432
             ||.:.||
Human   445 HAATQPDY 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	146/463 (32%)
TUBG2	NP_001307438.1	gamma_tubulin	3..444	CDD:276957	142/453 (31%)