Protein Alignment alphaTub85E and Tubb4b

DIOPT Version :10

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_666228.1
• Gene: Tubb4b / 227613
• MGIID: 1915472
• Length: 445
• Species: Mus musculus
• Alignment Length: 450
• Identity: 184/450 - (40%)
• Similarity: 270/450 - (60%)
• Gaps: 14/450 - (3%)

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDG--HMPSDKTVGGGDDSFSTFFSETGAGKHVP 63
            |||.:.:..||.|.|||...||:...||||.|.|  |..||..:    :..:.:::|...||:||
Mouse     1 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQL----ERINVYYNEATGGKYVP 61

  Fly    64 RAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQ 128
            |||.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||.|:.
Mouse    62 RAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAES 126

  Fly   129 CTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHT 193
            |..||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:.|:.|.
Mouse   127 CDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQ 191

  Fly   194 TLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQTN 258
            .:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:...|
Mouse   192 LVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVN 256

  Fly   259 LVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLYRGDV 323
            :||:||:||.:..:||:.|.....:..|||.|:|...|:..|.|..||||.|:|:....::||.:
Mouse   257 MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRM 321

  Fly   324 VPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAW 388
            ..|:|:..:..::.|.|..||:|.|...|..:...||        ..::.:...:.|:|||.|.:
Mouse   322 SMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMSATFIGNSTAIQELF 378

  Fly   389 ARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELGEDEE 448
            .|:..:|..|:.::||:|||.||||:|.||.||..::..|..:|::....:..|.||.||
Mouse   379 KRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEE 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	182/448 (41%)
Tubb4b	NP_666228.1	PLN00220	1..427	CDD:215107	179/437 (41%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..445		4/12 (33%)