Protein Alignment alphaTub85E and TUBB

DIOPT Version :9

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001280141.1
• Gene: TUBB / 203068
• HGNCID: 20778
• Length: 464
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 183/457 - (40%)
• Similarity: 271/457 - (59%)
• Gaps: 24/457 - (5%)

  Fly     2 RECISVHIGQAGVQIGNAC-------WELYCLEHGIQPDG--HMPSDKTVGGGDDSFSTFFSETG 57
            |..:..|.||....:.:|.       ||:...||||.|.|  |..||..:    |..|.:::|..
Human    15 RSGVRDHPGQQSETLPHATFLQKIKFWEVISDEHGIDPTGTYHGDSDLQL----DRISVYYNEAT 75

  Fly    58 AGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRI 122
            .||:||||:.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:
Human    76 GGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 140

  Fly   123 RKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNS 187
            ||.|:.|..||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:
Human   141 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNA 205

  Fly   188 ILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDL 252
            .|:.|..:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||
Human   206 TLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL 270

  Fly   253 TEFQTNLVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCM 317
            .:...|:||:||:||.:..:||:.|.....:..|||.|:|...|:..|.|..||||.|:|:....
Human   271 RKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAA 335

  Fly   318 LYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTT 382
            ::||.:..|:|:..:..::.|.|..||:|.|...|..:...||        ..::.||..:.|:|
Human   336 VFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMAVTFIGNST 392

  Fly   383 AIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELGEDE 447
            ||.|.:.|:..:|..|:.::||:|||.||||:|.||.||..::..|..:|::.. |:|.|  |:|
Human   393 AIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQ-DATAE--EEE 454

  Fly   448 EY 449
            ::
Human   455 DF 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	182/454 (40%)
TUBB	NP_001280141.1	PLN00220	39..449	CDD:215107	174/422 (41%)
		beta_tubulin	39..446	CDD:276956	173/418 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810