DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub85E and tba-6

DIOPT Version :9

Sequence 1:	NP_524297.1	Gene:	alphaTub85E / 41183	FlyBaseID:	FBgn0003886	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_492419.2	Gene:	tba-6 / 172717	WormBaseID:	WBGene00006532	Length:	464	Species:	Caenorhabditis elegans

Alignment Length:	448	Identity:	352/448 - (78%)
Similarity:	403/448 - (89%)	Gaps:	0/448 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGDDSFSTFFSETGAGKHVPRAV 66
            ||.||:|:||||||||||||||:||||||||||:...|.|.....::.:|||:||..||||||.:
Worm     8 REVISIHVGQAGVQIGNACWELFCLEHGIQPDGYHVEDDTYDEETETINTFFAETAGGKHVPRCL 72

  Fly    67 FVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQCTG 131
            ||||||||||||||||||.|||||||::|||||||.||||.||||:|::|||:||:::||:.|.|
Worm    73 FVDLEPTVVDEVRTGTYRSLFHPEQLLSGKEDAANCYARGRYTIGREMIDVVMDRVKRLAENCNG 137

  Fly   132 LQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLE 196
            ||||::||||||||||||.||||||||.:||||.||||:|||||||||::||||||||.||||||
Worm   138 LQGFVIFHSFGGGTGSGFLSLLMERLSTEYGKKPKLEFAIYPAPQVSTSMVEPYNSILMTHTTLE 202

  Fly   197 HSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVP 261
            ||||.|||||||||||||||||:.||||.|||||:.||:|||||||||:||||||||||||||||
Worm   203 HSDCTFMVDNEAIYDICRRNLDLARPTYTNLNRLVAQIISSITASLRFEGALNVDLTEFQTNLVP 267

  Fly   262 YPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLYRGDVVPK 326
            ||||||||.||||::|.|:|.|||.||:::|:|||||..||||||||||||||.|:|||||||||
Worm   268 YPRIHFPLVTYAPLVSAERASHEQNTVSDMTHACFEPGYQMVKCDPRRGKYMAVCLLYRGDVVPK 332

  Fly   327 DVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARL 391
            |:|:|||.:||||::|||:|||||||||||||||||||||||.|..|:|||:|||||||||||||
Worm   333 DINSAIAAVKTKRTVQFVEWCPTGFKVGINYQPPTVVPGGDLGKQTRSVCMISNTTAIAEAWARL 397

  Fly   392 DHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELGEDEEY 449
            |||||||||||||||||||||||||||:|||||:|||||||||:|.|...:..:|:.|
Worm   398 DHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEIGEDELPDDIDDQSY 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	351/445 (79%)
tba-6	NP_492419.2	PTZ00335	8..453	CDD:185562	350/444 (79%)
tba-6	NP_492419.2	alpha_tubulin	8..441	CDD:276955	347/432 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S25
OMA	1	1.010	-	-		QHG54134
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	1	1.100	-	-	O	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X95
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780