DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaTub85E and CG32396

DIOPT Version :9

Sequence 1:	NP_524297.1	Gene:	alphaTub85E / 41183	FlyBaseID:	FBgn0003886	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_729172.1	Gene:	CG32396 / 117406	FlyBaseID:	FBgn0052396	Length:	462	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	160/468 - (34%)
Similarity:	248/468 - (52%)	Gaps:	39/468 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVG--GGD-----DSFSTFFSETGA 58
            |||.:::.||.||..||::.|.:...|||:        |...|  ||.     :..:.||:.|.:
  Fly     1 MREIVTLQIGGAGNAIGDSFWHVISHEHGV--------DYASGRFGGTSPLQLERINVFFNATAS 57

  Fly    59 GKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIR 123
            .:...|.:.:|.|.:.:..:...:  ||:.||..:.|.|.|.||:|||::|.|..|:|.||:..|
  Fly    58 KRFYARTILIDTEASTIQRLNASS--QLYRPENFVAGSESAGNNFARGYHTDGAAILDQVLENTR 120

  Fly   124 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSI 188
            :..:....||||.:.||.|||||||.|||:||.|...|.......:...|:|.:|..||||||::
  Fly   121 REVESVDSLQGFQLLHSIGGGTGSGLTSLIMEALVEQYPDNLLCNYVTIPSPNMSQVVVEPYNAL 185

  Fly   189 LTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLT 253
            |:|...:.:|...|.:||||::.||.|||.::...|.::|.::...:|.||..|||.|.||..|.
  Fly   186 LSTPALVNNSHLTFCLDNEALFQICNRNLKLKMSGYEHINHIVALTMSGITTCLRFPGQLNAGLR 250

  Fly   254 EFQTNLVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCML 318
            :...|:||:||:||.:..:||:::.::....:.||:|:....|...|.:...|.|:||.:....:
  Fly   251 KIYVNMVPFPRLHFLIPGFAPLVTCKQQQFSKGTVSELVQQIFYSNNLLCAIDLRKGKLLTAAGI 315

  Fly   319 YRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTA 383
            :||.:.|::|:..:..::.|....||||.|...|..|...||        ..::.:...:.||||
  Fly   316 FRGRMSPREVDQLMTGVRNKNINNFVDWIPNNIKTAICDIPP--------RGLKMSATFIGNTTA 372

  Fly   384 IAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEE--VGIDS------- 439
            |...:.||......|..::|.:|||.||||||.||.:|:::|.|:..||..  .|.||
  Fly   373 IQTLFQRLLDASMSMLRRKAHLHWYTGEGMEEQEFQDAQQELQAIIDDYRSSAEGEDSGGGGGGG 437

  Fly   440 -----TTELGEDE 447
                 :.|.||:|
  Fly   438 GGRSGSAESGEEE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	160/468 (34%)
CG32396	NP_729172.1	PTZ00010	1..421	CDD:240228	151/437 (35%)
CG32396	NP_729172.1	beta_tubulin	2..425	CDD:276956	152/440 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910