Protein Alignment alphaTub85E and TUBB3

DIOPT Version :10

• Sequence 1: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_006077.2
• Gene: TUBB3 / 10381
• HGNCID: 20772
• Length: 450
• Species: Homo sapiens
• Alignment Length: 454
• Identity: 185/454 - (40%)
• Similarity: 272/454 - (59%)
• Gaps: 19/454 - (4%)

  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGD---DSFSTFFSETGAGKHV 62
            |||.:.:..||.|.|||...||:...||||.|.|:.     ||..|   :..|.:::|..:.|:|
Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNY-----VGDSDLQLERISVYYNEASSHKYV 60

  Fly    63 PRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLAD 127
            |||:.|||||..:|.||:|.:..||.|:..|.|:..|.||:|:||||.|.|:||.|||.:||..:
Human    61 PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECE 125

  Fly   128 QCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTH 192
            .|..||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:.|:.|
Human   126 NCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIH 190

  Fly   193 TTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQT 257
            ..:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|.||||.|.||.||.:...
Human   191 QLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAV 255

  Fly   258 NLVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLYRGD 322
            |:||:||:||.:..:||:.:.....:..|||.|:|...|:..|.|..||||.|:|:....::||.
Human   256 NMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGR 320

  Fly   323 VVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEA 387
            :..|:|:..:..|::|.|..||:|.|...||.:...||        ..::.:...:.|:|||.|.
Human   321 MSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPP--------RGLKMSSTFIGNSTAIQEL 377

  Fly   388 WARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAR---EDLAALEKDYEEVGIDSTTELGEDEE 448
            :.|:..:|..|:.::||:|||.||||:|.||.||.   .||.:..:.|::...:...|:.||:|
Human   378 FKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDE 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	184/452 (41%)
TUBB3	NP_006077.2	PLN00220	1..447	CDD:215107	185/454 (41%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..450		5/17 (29%)