DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxP and foxp1a

DIOPT Version :9

Sequence 1:	NP_001247011.1	Gene:	FoxP / 41182	FlyBaseID:	FBgn0262477	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_005162016.1	Gene:	foxp1a / 564127	ZFINID:	ZDB-GENE-060929-624	Length:	638	Species:	Danio rerio

Alignment Length:	524	Identity:	184/524 - (35%)
Similarity:	249/524 - (47%)	Gaps:	151/524 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QKEISVKSRH--------QISIPDICSDAVKNNCFPPTGFLNNSITFASHVVKCSSPA-----SS 74
            |:.:||:.:|        .:|:|...:.|:      |.|.:...:   ..:.|.::.|     |.
Zfish   166 QQLLSVQQQHLLNLQRQGLLSVPSALASAL------PQGLIPAEL---QQLWKETADARQEEKSR 221

  Fly    75 IDESSTAAQQHESNPHMHIQGQHMMAPVPDLGFYNVPEFISEQEKLMFSDAERFLRSKDNEVCNN 139
            .|:|.:..:....|.|....|.|:..|:         ...|.||.
Zfish   222 GDKSPSPPKTQTLNHHSSTNGHHLQRPI---------RRDSSQES-------------------- 257

  Fly   140 DFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVS 204
                 |.:..     |||::||:|:||||:....|..||:||||:||.|||:||||.|||||||.
Zfish   258 -----HPQSG-----HPLYSHGVCKWPGCDAVFGDFQSFLKHLNSEHALDDKSTAQCRVQMQVVQ 312

  Fly   205 QLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVPGREGKFCRSPLTVNSIGRP-------- 261
            |||..|.|:::||||||.||::..   :.||      |..:.....|.||:..:..|
Zfish   313 QLELQLAKDKERLQAMMAHLHVKS---TETK------PAPQPVNLVSNLTLAKVTVPKSTPSMSL 368

  Fly   262 IRQTNSPS-PL-NLPMVNS----TNLCS---IKKRNHDKNTFSINGGLPYMLERAGLDVQQEIHR 317
            .:...:|| || :||...|    |:|.|   |:||..||  |:|             .:.|:|.:
Zfish   369 SQSATAPSTPLTSLPQTPSVIIPTSLHSMGPIRKRYSDK--FNI-------------AMDQDIVQ 418

  Fly   318 NREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAIRTNLSL 382
            |:|||.:|:||||||||:||||||::||:||||||||||||..||.||||||||||||:|.||||
Zfish   419 NKEFYLSAEVRPPFTYAALIRQAILESPEKQLTLNEIYNWFTRTFAYFRRNAATWKNAVRHNLSL 483

  Fly   383 HKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEPSSSPNSCQSGNGVPTDKNPCDNCTQHC 447
            ||||||.|:..|:.|.||:.||.||      ||:|.            .|.|..||...|..|
Zfish   484 HKCFVRVENVKGAVWTVDELEFQKR------RPQKI------------TGSPLVKNIQSNLAQ-- 528

  Fly   448 TSLPPGADNP---------LDSNNPNDLGRIGCLPYCGSDGLSKASKDYSNMDSGMIESNSHLTI 503
                    :|         :||:          ||..||..:..:|  ...:...::|..|....
Zfish   529 --------SPALSALQAVMVDSS----------LPLYGSASMGASS--LKALSGALLEDLSPHDH 573

  Fly   504 DEYS 507
            ||.|
Zfish   574 DEAS 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:292777	42/66 (64%)
FoxP	NP_001247011.1	FH	328..400	CDD:238016	55/71 (77%)
foxp1a	XP_005162016.1	FOXP-CC	265..332	CDD:292777	42/66 (64%)
foxp1a	XP_005162016.1	FH	429..501	CDD:238016	55/71 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5255
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001519
OrthoInspector	1	1.000	-	-		otm25338
orthoMCL	1	0.900	-	-		OOG6_103982
Panther	1	1.100	-	-	O	PTHR45796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.870