DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxP and FOXK2

DIOPT Version :10

Sequence 1:NP_001247011.1 Gene:FoxP / 41182 FlyBaseID:FBgn0262477 Length:520 Species:Drosophila melanogaster
Sequence 2:NP_004505.2 Gene:FOXK2 / 3607 HGNCID:6036 Length:660 Species:Homo sapiens


Alignment Length:228 Identity:66/228 - (28%)
Similarity:100/228 - (43%) Gaps:38/228 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   251 SPLTVNSIGRPIRQTNSPSPLNLPMVNSTNLCSIKKRNHDKNTFSINGGLPYML----------- 304
            ||||:| |...:....||.|.....:::.|.|....|....:.:.:...:|..|           
Human   180 SPLTIN-IPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQPEN 243

  Fly   305 --ERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRR 367
              |.:|.|..::           |.:||::||.||.|||..:||||||||.||......:.|:|.
Human   244 EKEASGGDSPKD-----------DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRT 297

  Fly   368 NAATWKNAIRTNLSLHKCFVRY-----EDDFGSFWMVD---DNEFVKRRHLSRGRPRKYEPSSSP 424
            ....|:|:||.||||::.|::.     |...||||.:|   :::.:::....| |||......:|
Human   298 ADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKR-RPRGVPCFRTP 361

  Fly   425 NSCQSGNGVPTDKNPCDNCTQHCTSLPPGADNP 457
            ....|....|...|.....:.|.:    ||..|
Human   362 LGPLSSRSAPASPNHAGVLSAHSS----GAQTP 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxPNP_001247011.1 FOXP-CC 157..224 CDD:465036
FH_FOX 327..408 CDD:469596 36/88 (41%)
FOXK2NP_004505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
FHA_FOXK2 35..157 CDD:438775
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..104
Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269|PubMed:25805136 129..171
COG5025 <180..577 CDD:227358 66/228 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..260 9/67 (13%)
FH_FOXK2 256..353 CDD:410829 39/97 (40%)
DNA-binding, major groove. /evidence=ECO:0000269|PubMed:16624804 300..318 9/17 (53%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 328..332 2/3 (67%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 348..353 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..407 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..632
Blue background indicates that the domain is not in the aligned region.

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