Protein Alignment FoxP and FOXI3

DIOPT Version :10

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001129121.1
• Gene: FOXI3 / 344167
• HGNCID: 35123
• Length: 420
• Species: Homo sapiens
• Alignment Length: 222
• Identity: 66/222 - (29%)
• Similarity: 102/222 - (45%)
• Gaps: 33/222 - (14%)

  Fly   327 VRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAIRTNLSLHKCF---VR 388
            ||||::|::||..||..:|:::|||:.||.:..::|.:::|:.|.|:|:||.||||:.||   .|
Human   144 VRPPYSYSALIAMAIQSAPERKLTLSHIYQFVADSFPFYQRSKAGWQNSIRHNLSLNDCFKKVPR 208

  Fly   389 YEDD--FGSFWMVDDN--EFVKRRHLSRGRPRKYEPSS----------SPNSCQSG-----NGVP 434
            .|||  .|::|.:|.|  :.....:..|.|.|:.|.|:          |.....||     .|.|
Human   209 DEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRSEASNGSTVAAGTSKSEEGLSSGLGSGVGGKP 273

  Fly   435 TDKNPCDNC-TQHCTSLPPGADNPLDSNNPNDLGRIGCLPYCGSDGLSKASKDYSNMDSGMIESN 498
            .:::|.... ..|....|.|..:...|.....|....||....| .||..|...|......:..:
Human   274 EEESPSTLLRPSHSPEPPEGTKSTASSPGGPMLTSTPCLNTFFS-SLSSLSVSSSVSTQRALPGS 337

  Fly   499 SHLTIDEYS---------TNMYESSAN 516
            .||.|....         |::.|:||:
Human   338 RHLGIQGAQLPSSGVFSPTSISEASAD 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036
		FH_FOX	327..408	CDD:469596	36/87 (41%)
FOXI3	NP_001129121.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..122
		FH_FOXI1	142..241	CDD:410827	38/96 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..306		15/71 (21%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:37041148	235..241		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..396		0/1 (0%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:D3Z120	406..414