DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxP and Foxp1

DIOPT Version :9

Sequence 1:	NP_001247011.1	Gene:	FoxP / 41182	FlyBaseID:	FBgn0262477	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_038963305.1	Gene:	Foxp1 / 297480	RGDID:	1308669	Length:	733	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	174/478 - (36%)
Similarity:	235/478 - (49%)	Gaps:	135/478 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TGFLNNSITFASHVVKCSSPASSIDESSTAAQQHESNPHMHIQGQHMMAPVPDLGFYNVPEFISE 116
            ||..::|:...|..|..|:|      |.|:...   |||....|| :....|            :
  Rat   301 TGSNHSSLDLTSTCVSSSAP------SKTSLIM---NPHASTNGQ-LSVHTP------------K 343

  Fly   117 QEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKH 181
            :|.|                       .|:|   ..:.|||:.||:|:|||||...:|..:|:||
  Rat   344 RESL-----------------------SHEE---HPHSHPLYGHGVCKWPGCEAVCDDFPAFLKH 382

  Fly   182 LNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVPGREG 246
            ||:||.||||||||.|||||||.|||..|.|:::||||||.||:               |...|.
  Rat   383 LNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLH---------------VKSTEP 432

  Fly   247 KFCRSPLTVNSIGRPIRQTNSPSPLNLP------------------MVNSTNLCS---IKKRNHD 290
            |....||.:.|.....:..:..||.:||                  ::.:|::.:   |::|..|
  Rat   433 KAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSD 497

  Fly   291 KNTFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIY 355
            |....|:..              :|.:|:||||||:|||||||||||||||::||:|||||||||
  Rat   498 KYNVPISSA--------------DIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIY 548

  Fly   356 NWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEP 420
            |||...|.||||||||||||:|.||||||||||.|:..|:.|.||:.||.||      ||:|.
  Rat   549 NWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKR------RPQKI-- 605

  Fly   421 SSSPN---SCQSGNGVPTDKNPCDNCTQHCTSLPPG-----ADNPLDSNNPNDLGRIGCLPYCGS 477
            |.:|:   :.|||:.             :||.|...     |:|.:.......:|.    |..||
  Rat   606 SGNPSLIKNMQSGHA-------------YCTPLNAALQASMAENSIPLYTTASMGN----PTLGS 653

  Fly   478 DGLSKASKDYSNMDSGMIESNSH 500
              |:.|.::  .::..|..:||:
  Rat   654 --LASAIRE--ELNGAMEHTNSN 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:292777	43/66 (65%)
FoxP	NP_001247011.1	FH	328..400	CDD:238016	55/71 (77%)
Foxp1	XP_038963305.1	FOXP-CC	358..425	CDD:406546	43/66 (65%)
		COG5025	493..>707	CDD:227358	96/223 (43%)
		FH_FOXP2	520..601	CDD:410839	62/86 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5287
eggNOG	1	0.900	-	-		E2759_KOG4385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001519
OrthoInspector	1	1.000	-	-		otm45502
orthoMCL	1	0.900	-	-		OOG6_103982
Panther	1	1.100	-	-	LDO	PTHR45796
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X957
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770