Protein Alignment FoxP and FOXP1

DIOPT Version :10

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001231739.1
• Gene: FOXP1 / 27086
• HGNCID: 3823
• Length: 693
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 181/475 - (38%)
• Similarity: 242/475 - (50%)
• Gaps: 113/475 - (23%)

  Fly    52 TGFLNNSITFASHVVKCSSPASSIDESSTAAQQHESNPHMHIQGQHMMAPVPDLGFYNVPEFISE 116
            ||..::|:...:..|..|:|      |.|:...   |||....|| :....|            :
Human   245 TGNNHSSLDLTTTCVSSSAP------SKTSLIM---NPHASTNGQ-LSVHTP------------K 287

  Fly   117 QEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKH 181
            :|.|                       .|:|   ..:.|||:.||:|:|||||...||..||:||
Human   288 RESL-----------------------SHEE---HPHSHPLYGHGVCKWPGCEAVCEDFQSFLKH 326

  Fly   182 LNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVPGREG 246
            ||:||.||||||||.|||||||.|||..|.|:::||||||.||:               |...|.
Human   327 LNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLH---------------VKSTEP 376

  Fly   247 KFCRSPLTVNSIGRPIRQTNSPSPLNLP------------------MVNSTNLCS---IKKRNHD 290
            |....||.:.|.....:..:..||.:||                  ::.:|::.:   |::|..|
Human   377 KAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSD 441

  Fly   291 KNTFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIY 355
            |....|:..              :|.:|:||||||:|||||||||||||||::||:|||||||||
Human   442 KYNVPISSA--------------DIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIY 492

  Fly   356 NWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEP 420
            |||...|.||||||||||.||||||||||||:|.||:|||||.|||.||.:.||:.|||||||.|
Human   493 NWFTRMFAYFRRNAATWKGAIRTNLSLHKCFIRVEDEFGSFWTVDDEEFKRGRHIQRGRPRKYCP 557

  Fly   421 SSSPNSCQSGNGVPTDKNPCDNCTQHCTSLPPG-----ADNPLDSNNPNDLGRIGCLPYCGSDGL 480
            ..:.:...:.|  |:......:...:||.|...     |:|.:.......:|.    |..|:  |
Human   558 DENFDELVAHN--PSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGN----PTLGN--L 614

  Fly   481 SKASKDYSNMDSGMIESNSH 500
            :.|.::  .::..|..:||:
Human   615 ASAIRE--ELNGAMEHTNSN 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036	45/66 (68%)
		FH_FOX	327..408	CDD:469596	65/80 (81%)
FOXP1	NP_001231739.1	FOXP-CC	302..369	CDD:465036	45/66 (68%)
		FH_FOX	464..545	CDD:469596	65/80 (81%)