Protein Alignment FoxP and FOXO1

DIOPT Version :10

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 56/200 - (28%)
• Similarity: 89/200 - (44%)
• Gaps: 52/200 - (26%)

  Fly   332 TYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFR-----RNAATWKNAIRTNLSLHKCFVRYED 391
            :||.||.:||..|.:|:|||::||.|...:..||:     .::|.|||:||.|||||..|:|.::
Human   164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 228

  Fly   392 D---FGSFWMVD-----DNEFVKRRHLS--------RGRPRKYEPSSSPNSCQSGNGVPTDKNPC 440
            :   ..|:||::     ..:..:||..|        :.|.|..:..:|..|.|.|.|
Human   229 EGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAG-------- 285

  Fly   441 DNCTQHCTSLP--PGA------DN-----PLDSNNPNDLGRIGCLPYCGSDGLSKASKDYSNMDS 492
            |:.....:..|  ||:      ||     |..|:|.:.:          |..||....:..::..
Human   286 DSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTI----------SGRLSPIMTEQDDLGE 340

  Fly   493 GMIES 497
            |.:.|
Human   341 GDVHS 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036
		FH_FOX	327..408	CDD:469596	32/88 (36%)
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158
		FH_FOXO1	151..249	CDD:410834	32/84 (38%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		4/6 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		26/127 (20%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		1/2 (50%)
		Nuclear localization signal	251..253		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		15/80 (19%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459
		FOXO_KIX_bdg	423..504	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537
		FOXO-TAD	597..633	CDD:435506