DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and AREL1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	821	Identity:	177/821 - (21%)
Similarity:	287/821 - (34%)	Gaps:	258/821 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2172 SKYEKVVLMETDDSLPSTSK-----STEALMATRPEVI-IAPNKASVSPATAARSVIVLAGGSCL 2230
            |.|.|:  .:....:||.:|     ||..|...:|..: |.|.....:|...:.|:
Human   152 SPYYKI--FQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSL--------- 205

  Fly  2231 KTIDSDINNYSAS--NLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRW 2293
                .|.:||:.|  .|...|:......::||.:.:
Human   206 ----RDEHNYTLSIHELGPQEEESTGVSFEKSVTSN----------------------------- 237

  Fly  2294 KLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIV 2358
            :.|..:|.|:.:...|..|..:              ....:.:.||:...:||.:.|:|    ||
Human   238 RQTFQVFLRLTLHSRGCFHACI--------------SYQNQPINNGEFDIIVLSEDEKN----IV 284

  Fly  2359 QTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQ 2423
            :  :.::|                             |||:..|     ||.|.:|
Human   285 E--RNVST-----------------------------SGVSIYF-----EAYLYNA--------- 304

  Fly  2424 VGTNHSK---YVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPN 2485
              ||.|.   ::.|.              ..::.|||.|.:              :|......|
Human   305 --TNCSSTPWHLPPM--------------HMTSSQRRPSTA--------------VDEEDEDSP- 338

  Fly  2486 SSDNATPESLNDHLSV--------------HLQQIGERLY-------PKIHSINQTHAPKITGML 2529
             |:..|||.:.....|              :|:.|..|||       .|...:......|:..::
Human   339 -SECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLV 402

  Fly  2530 LE--IPTPQLLSV-----------------ISSDETLRQKVN----EAIEI--------ITFKQK 2563
            ::  |..|..||.                 |...||.:.|||    |..::        :|.|..
Human   403 VDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVS 467

  Fly  2564 SETSAQSSQPKKSPSVVVVD------PVDDDNEPLFYSPGKRGFY---------TPRQGFASFE- 2612
            .....:||. |.:.:..:.|      .|..|.|.|.:...:|.::         |..|.|..|.
Human   468 RHALLESSL-KATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSD 531

  Fly  2613 ----------------RINAFRNIGRLIGLCLLQNELLPLFLQ-------RHVLKYILGRKIKFH 2654
                            |:..:...|||:|.||.::.|...:.|       |..|..|:|.::.:.
Human   532 NNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYK 596

  Fly  2655 DLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNR--ELIPGGRDVAVTSS 2717
            .....||..|:|....|.|....|       |||.|..:...:.|..::  ||:.||....||::
Human   597 YFETDDPEFYKSKVCFILNNDMSE-------MELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNA 654

  Fly  2718 NIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYT 2782
            |...|:....:|||....::.:|....|:.:::|:|.:......:|.||:.|.|||:||...::.
Human   655 NKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHA 719

  Fly  2783 TFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIRPA- 2845
            .....|....:|::   :|||::|..:...|...|:.|.|||..||..  ||..| ||..|..|
Human   720 VVVGGSWHFREKVM---RWFWTVVSSLTQEELARLLQFTTGSSQLPPG--GFAALCPSFQIIAAP 779

  Fly  2846 DDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ..|.||||:||.::|.:|.|.|...:...:.:||.....||
Human   780 THSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	20/114 (18%)
		HECTc	2589..2885	CDD:238033	90/332 (27%)
		HECTc	2589..2884	CDD:214523	90/331 (27%)
AREL1	NP_001034568.1	Filamin	52..158		3/7 (43%)
		Filamin	56..154	CDD:395505	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		9/59 (15%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		85/317 (27%)
		HECTc	486..820	CDD:214523	93/345 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900