DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and MAGI2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_016868329.1	Gene:	MAGI2 / 9863	HGNCID:	18957	Length:	1540	Species:	Homo sapiens

Alignment Length:	1207	Identity:	245/1207 - (20%)
Similarity:	374/1207 - (30%)	Gaps:	391/1207 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1126 AQRREHALTILQQMCVSPALRPYLCHM-LSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQ 1189
            |..|..::..|......||.||:|... |.|:||.......||.:.:....|...  ||:...|.
Human   427 APERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFGF--TIIGGDEP 489

  Fly  1190 DPQLKEAMIFPNGSPADQSPLH---VICY-NDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTE 1250
            |..|:...:.|:|..|....:.   ||.| |:.|....|.||.:  .:|:....|.:.:|..|
Human   490 DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVV--KLFQSVPIGQSVNLVLC-- 550

  Fly  1251 CARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESI 1315
                  :|:........|                |.::....|::
Human   551 ------RGYPLPFDPEDP----------------ANSMVPPLAIM-------------------- 573

  Fly  1316 LLFLIQTVGRQIVEQRQYRFSVRVR-NVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLE--- 1376
                          :|.....|..| |..|..       ..||....|..:| .|.|.|.|.
Human   574 --------------ERPPPVMVNGRHNYETYL-------EYISRTSQSVPDI-TDRPPHSLHSMP 616

  Fly  1377 ---------PPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQH 1432
                     ||.         :.|.|.  ||..|||.:.::.    :.:....::||
Human   617 TDGQLDGTYPPP---------VHDDNV--SMASSGATQAELM----TLTIVKGAQGF-------- 658

  Fly  1433 GSTLLDKFTHSLIVK----------CTSDHLDTLLLTLVRELQNASVSNRS-KEAEEVVRRF-VR 1485
            |.|:.|..|...:.:          |..|        |:.|:...:|.|.| .|..::::.. :.
Human   659 GFTIADSPTGQRVKQILDIQGCPGLCEGD--------LIVEINQQNVQNLSHTEVVDILKDCPIG 715

  Fly  1486 SVARVFV----IFNLEKQPNP-EKRKSHSSCNKYVQSCVKVFQ------TLHKISIE-------- 1531
            |...:.:    .|:..|.|.| ..|..:....:...|...:.|      .||:.|..
Human   716 SETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP 780

  Fly  1532 ------ELCEVSEALIAPVRLGVVRPTAPFTMSSS-----NLDV--RNSDDLFSVDPLAPSNVES 1583
                  ||.|.|.|:....:  .|.|...|.|.||     .|||  |..:..|....|..   :.
Human   781 RKPDPYELYEKSRAIYESRQ--QVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG---DE 840

  Fly  1584 PSEQILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVINREANSHNQDDELIENQRNEDGM 1648
            |.:.||:.                .|:||.:          .:|:...| ..|||:    ..||:
Human   841 PGQPILIG----------------AVIAMGS----------ADRDGRLH-PGDELV----YVDGI 874

  Fly  1649 QDDESDNDFTFNDAETESDSDDNQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGS 1713
            ......:.:..:  .....:.:.|.|..|:|.|..|.....||                    |.
Human   875 PVAGKTHRYVID--LMHHAARNGQVNLTVRRKVLCGGEPCPEN--------------------GR 917

  Fly  1714 EDG-----ESDDQSDEFNFNEQQLERRSTNSN--ARSDLAPQTMQWAIRSRDTARSSVRVPTGSN 1771
            ..|     .|..:||...:         ||||  |.|..|.....:|..|..|:...:.......
Human   918 SPGSVSTHHSSPRSDYATY---------TNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEG 973

  Fly  1772 MVFIDPMALRRSTVPAS-TTVTTPSIEPHTM-----ATTASNLARAFGITIRQISELISILSYNV 1830
            ..|:...:|.|   |.| :|:|.    ||.:     .:.|...|:     ::....::::...::
Human   974 FGFVIISSLNR---PESGSTITV----PHKIGRIIDGSPADRCAK-----LKVGDRILAVNGQSI 1026

  Fly  1831 LN----DIETSLKIQNDEAIAV--QAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHP 1889
            :|    ||   :|:..|..::|  :...::.|.:.     |....:|.|           .|...
Human  1027 INMPHADI---VKLIKDAGLSVTLRIIPQEELNSP-----TSAPSSEKQ-----------SPMAQ 1072

  Fly  1890 LHPLNLSAQASSSQTPAPATSSS-------VNGVNIMG-SNSRRDFFTYCLSLMRSHTSEHRDAL 1946
            ..||   ||.|....|:|||.:|       ...:.:.| .||           .||.....:|..
Human  1073 QSPL---AQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENS-----------YRSEVKARQDVK 1123

  Fly  1947 PVLDITALRHIAY---VLDAFVYYMRNDSGFYDKQDTISGRINNL------SPMTESYDTDD--E 2000
            |  ||.......|   .||    |.:...|.|.:...:..|...|      ||.|..|...|  :
Human  1124 P--DIRQPPFTDYRQPPLD----YRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQ 1182

  Fly  2001 LANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDM-AMPLA-DKPH 2063
            ..:.:.|..|       |..|::|               .|.|...|.|..:|: .:.|| |.|
Human  1183 PQDFDYFTVD-------MEKGAKG---------------FGFSIRGGREYKMDLYVLRLAEDGP- 1224

  Fly  2064 LLQPNSKRQELFANLPLLVTTNANNSGATNDGD------GGSIFDYTPTR-LGFSNSLKRNERVY 2121
                                  |..:|....||      |.|..|.|..| :....|..|..|:.
Human  1225 ----------------------AIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLL 1267

  Fly  2122 ETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKK-KQGSDDFKSHKEADGNQSKYEKVVLMETDD- 2184
                   .|.|.|.|..  .|...|::.:.:|. |.||..|    ...|:....|:..|..||:
Human  1268 -------LKRGTGQVPE--YGMVPSSLSMCMKSDKHGSPYF----YLLGHPKDTERSKLARTDNR 1319

  Fly  2185 -SLPSTSKSTEALMATRPEVIIA--PNKASVSPATAA 2218
             ..|:...|..|.....|||.::  ...|..||:..|
Human  1320 KDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPA 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	10/66 (15%)
		ASF1_hist_chap	1535..1733	CDD:304562	41/209 (20%)
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
MAGI2	XP_016868329.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900