DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and TRIP12

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_024308991.1 Gene:TRIP12 / 9320 HGNCID:12306 Length:2092 Species:Homo sapiens


Alignment Length:2670 Identity:479/2670 - (17%)
Similarity:827/2670 - (30%) Gaps:936/2670 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   567 NTNSGVDKSQAAGNNLNAH------------------GITPDKDLPKSTAMP-----STGSSKNG 608
            |.|.|....::..|...|.                  |.:|.:....::..|     :|.....|
Human     6 NNNPGGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKHKGYSPPESRKSNSKAPKVQSNTTSELSRG 70

  Fly   609 QSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTSHKRTKRATTKEDSNAPQEGRKDEELWEVKDV 673
            .....|..|:..:.:|.|..|      |..:.:..::|.:...|::|...:.....:        
Human    71 HLSKRSCSSSSAVIVPQPEDP------DRANTSERQKTGQVPKKDNSRGVKRSASPD-------- 121

  Fly   674 VFVEDKVGPVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGKE-----DDWQ 733
                                    :...|:.:.|....|...|.:.:.|:|...|.     |..|
Human   122 ------------------------YNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ 162

  Fly   734 QCRLLRREDVQIFRTAMS-TRGPDWLQKQPK------KINVGGDAAGAQILTLAVDSRGIHVIKK 791
            |.:..:........|..| ..|....||:.:      |...|.::.||       :.|.....| 
Human   163 QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGA-------EERSAKPTK- 219

  Fly   792 VLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGALYPL 856
                    |.:......:..|...||.:|...::..:..:|      ..|||:    ..||....
Human   220 --------LASKSATSAKAGCSTITDSSSAASTSSSSSAVA------SASSTV----PPGARVKQ 266

  Fly   857 AKD--------------------------CLGSIKDPQWFD----LPPVKSITMSTISLPAML-- 889
            .||                          ..||.|    ||    ..|..|:..:.:|||...  
Human   267 GKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSK----FDWAARFSPKVSLPKTKLSLPGSSKS 327

  Fly   890 -------SGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTALVVEERCDG 947
                   ||:..|    :.:|...|:|..        ::..|.|..|.|..:..|.        |
Human   328 ETSKPGPSGLQAK----LASLRKSTKKRS--------ESPPAELPSLRRSTRQKTT--------G 372

  Fly   948 ARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSN 1012
            :          ||.:|.:.|       |:.|:   |.:.||....:: ....:..|..:||:.::
Human   373 S----------CASTSRRGS-------GLGKR---GAAEARRQEKMA-DPESNQEAVNSSAARTD 416

  Fly  1013 ENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQA--EQSGSQPMATNNEDHAYIPWPAE 1075
            |....|..|||.||:...|:.....:....|.||    ||  |..|..|       |.:.|.   
Human   417 EAPQGAAASSSVAGAVGMTTSGESESDDSEMGRL----QALLEARGLPP-------HLFGPL--- 467

  Fly  1076 TPAASNLSASSSQNVSDSIEDDISKIIPSSSQSSMLSNI----KLGSPTYTFDLAQRREHALTIL 1136
            .|..|.|...:..:.:.|....:.:.:.:|.:|..|..:    :|        |....|..|...
Human   468 GPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQL--------LVMGNEETLGGF 524

  Fly  1137 QQMCVSPALRPYLCHMLSTKDAQGQTPF-MLSVSCRAYEAGIILLNTILMLSEQDPQLKEAMIFP 1200
            ....|.|||...|         |.:..| :::.:|||          :..:.|..|  :.:.:..
Human   525 PVKSVVPALITLL---------QMEHNFDIMNHACRA----------LTYMMEALP--RSSAVVV 568

  Fly  1201 NGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKL-- 1263
            :..|.....|.||...|......|..:.:::.  ..|.....|.|.             ||.|  
Human   569 DAIPVFLEKLQVIQCIDVAEQALTALEMLSRR--HSKAILQAGGLA-------------DCLLYL 618

  Fly  1264 -------KRTAPTAYCDCWEK-------------------------------CKCKALIAGNLTK 1290
                   :|.|.....:|.:.                               |.|.|.:..|...
Human   619 EFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQH 683

  Fly  1291 RFALLCKLVSCTDLVTKFNSKGESILLFL--IQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNN 1353
            ...|| :.|:..||:|..    :.:|:..  |.:.|..|:..|.  ||:...|..|.|......|
Human   684 EENLL-QQVASKDLLTNV----QQLLVVTPPILSSGMFIMVVRM--FSLMCSNCPTLAVQLMKQN 741

  Fly  1354 ------SVISNRKTSAAEIDNDM----PDH---------DLEP--PKFARKALERLLIDWNAVRS 1397
                  .::......:.:...|:    |..         :|.|  ||....|::.:|        
Human   742 IAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTML-------- 798

  Fly  1398 MIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSDHL--DTLLLTL 1460
                  ::|:..|..|:..:..:..|.      .|....:|    |.|::..:..:  |.:.|:.
Human   799 ------KKGNAQNTDGAIWQWRDDRGL------WHPYNRID----SRIIEVAAHQVGEDEISLST 847

  Fly  1461 VRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQS-------- 1517
            :..:.....::..:..|:.      ..||.     ::::|||   .::|:.:.|.:|        
Human   848 LGRVYTIDFNSMQQINEDT------GTARA-----IQRKPNP---LANSNTSGYSESKKDDARAQ 898

  Fly  1518 CVKVFQTLHKISIEE----LCEVSEALIAP-VR---LGVVRPTAPFTMSSSNLDVRNSDDLFSVD 1574
            .:|....|.|..|:.    |.||..:...| ||   |..:.....|..:....||..:   .:|.
Human   899 LMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKN---HAVS 960

  Fly  1575 PLAPSNVESPSEQILVHDAGNDQSANFNIQQNYDVVA--------METIRDASESEEVINREANS 1631
            ....|.:.|...:|:|   |..|.|...:|:..|:.:        |..::..:|||.::.....:
Human   961 SHIASMLSSQDLKIVV---GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKA 1022

  Fly  1632 HNQDDELIENQRNEDGMQDDESDNDFTFNDAETESDSDDNQSNQEVQRSVQAGATVGSEN---DI 1693
            ..          |..|.....:                          ||.:|....:.:   |:
Human  1023 CT----------NGSGSMGSTT--------------------------SVSSGTATAATHAAADL 1051

  Fly  1694 GVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNARSDLAPQTMQWAIRSRD 1758
            |...|:....||.    |.|..|...|.     ...::|.:|...   |...:|......:.::.
Human  1052 GSPSLQHSRDDSL----DLSPQGRLSDV-----LKRKRLPKRGPR---RPKYSPPRDDDKVDNQA 1104

  Fly  1759 TARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPHTMATTA--SNLARAFGITIRQISE 1821
            .:.::.:.|..|.:..::|....|    .||...:.:|||   |.||  |.||||..      .:
Human  1105 KSPTTTQSPKSSFLASLNPKTWGR----LSTQSNSNNIEP---ARTAGGSGLARAAS------KD 1156

  Fly  1822 LISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDP 1886
            .||    |....|:..:|.|      ...|||:...:      ..|||:...|.....|...|: 
Human  1157 TIS----NNREKIKGWIKEQ------AHKFVERYFSS------ENMDGSNPALNVLQRLCAATE- 1204

  Fly  1887 NHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDI 1951
                 .|||.....:.                            ||..:||..||.       |:
Human  1205 -----QLNLQVDGGAE----------------------------CLVEIRSIVSES-------DV 1229

  Fly  1952 TA--LRHIAYVLDAFVYYMRNDSGFYDKQDTIS-----------------------GR---INNL 1988
            ::  ::|..:|....:|....     .::|.:|                       ||   :.|.
Human  1230 SSFEIQHSGFVKQLLLYLTSK-----SEKDAVSREIRLKRFLHVFFSSPLPGEEPIGRVEPVGNA 1289

  Fly  1989 SPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAP-------- 2045
            ..:...:..::.|:.:|:|...|....|...:|.:|::...||    :|..|.|...        
Human  1290 PLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGRGSQALKFF----NTHQLKCQLQRHPDCANV 1350

  Fly  2046 ---EGFELPLDMAMPLADKPHLLQPNSK----------RQELFANLPLLVTTNANNSGATNDGDG 2097
               :|..:.:|   |||    |:|...:          |::         ..::::.|:..:.|.
Human  1351 KQWKGGPVKID---PLA----LVQAIERYLVVRGYGRVRED---------DEDSDDDGSDEEIDE 1399

  Fly  2098 GSIFDYTPT----------------------------------RLGF---SNSLKRNERVYETVP 2125
            ..:..|.||                                  ||.|   .:.|..|..||:.|.
Human  1400 SLVRYYIPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVR 1464

  Fly  2126 IDSSKTGDGNVTNKAEGSTDSNIYVQLKK-----KQGSDDFKSHKEADG---------------- 2169
            ..|.:..|...:...|.:......:..|.     |...:|.:|:|:..|                
Human  1465 QFSIQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPR 1529

  Fly  2170 NQSKYEKVVLMETDDSLPSTSKSTEA-LMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTI 2233
            |..|:::   :..|...||.|...|. |:.|.||        :::....:..||:|     |:.:
Human  1530 NAKKHDE---LWHDGVCPSVSNPLEVYLIPTPPE--------NITFEDPSLDVILL-----LRVL 1578

  Fly  2234 DSDINNY---------------SASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSEL 2283
            .: |:.|               ::..:::...||.:.|.|    |.|::..           ..:
Human  1579 HA-ISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQ----DPLVIMT-----------GNI 1627

  Fly  2284 PSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRF-------RRHMEKL----- 2336
            |:|        ||              |.|...|....|..::|.|       .|.|::|     
Human  1628 PTW--------LT--------------ELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNP 1670

  Fly  2337 ---RNGQQRDLVLCKLER-----NRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPG 2393
               ::..|...|..:|:|     |||.|:.|.  |...|....||.:        :::.:::|.|
Human  1671 EINQSDSQDSRVAPRLDRKKRTVNREELLKQA--ESVMQDLGSSRAM--------LEIQYENEVG 1725

  Fly  2394 EGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRG 2458
            .|.|....||..:::         .|:...:|                                 
Human  1726 TGLGPTLEFYALVSQ---------ELQRADLG--------------------------------- 1748

  Fly  2459 SNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQI-GERLYPKIHSINQTHA 2522
                 |||.  |...|       :.|..|...|.         ::|.: |....|...:....|.
Human  1749 -----LWRG--EEVTL-------SNPKGSQEGTK---------YIQNLQGLFALPFGRTAKPAHI 1790

  Fly  2523 PKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDD 2587
            .|:                                   |.|                        
Human  1791 AKV-----------------------------------KMK------------------------ 1796

  Fly  2588 DNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRK-- 2650
                                         ||.:|:|:...::...|:.|.|.....|::|.::  
Human  1797 -----------------------------FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETS 1832

  Fly  2651 IKFHDLAFFDPALYES---FRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG----------- 2701
            :..|||...||.:..|   ...|::..:..|.:::..:..|.:.::.:...||.           
Human  1833 LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLP 1897

  Fly  2702 ---NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDL 2763
               |.||..||:|:.||..|:.||:|....:.|.:...:..::.:||...|.|.:.:.....|:|
Human  1898 GFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEEL 1962

  Fly  2764 RLLLNG--VGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPA 2826
            ..||.|  ....:..||:.... .|.......:.:||   .:.|:...:..:::..:.|.||||.
Human  1963 DQLLCGSKADTWDAKTLMECCR-PDHGYTHDSRAVKF---LFEILSSFDNEQQRLFLQFVTGSPR 2023

  Fly  2827 LPASEEGFQPL-PSVTI---------RPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKS 2881
            ||..  ||:.| |.:||         .|  |..||:..||::.|.:|.|||..|:|.|:|:|.:.
Human  2024 LPVG--GFRSLNPPLTIVRKTFESTENP--DDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 2084

  Fly  2882 KNFGF 2886
            ....|
Human  2085 GQQSF 2089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 14/106 (13%)
ASF1_hist_chap 1535..1733 CDD:304562 37/212 (17%)
PolyA 2498..2561 CDD:197769 5/63 (8%)
HECTc 2589..2885 CDD:238033 77/326 (24%)
HECTc 2589..2884 CDD:214523 77/325 (24%)
TRIP12XP_024308991.1 SR-25 99..>233 CDD:313680 25/181 (14%)
Arm_3 489..>714 CDD:330530 46/273 (17%)
WWE 808..874 CDD:308464 11/86 (13%)
HECTc 1690..2090 CDD:238033 110/571 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.