DRSC/TRiP Functional Genomics Resources

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Protein Alignment hyd and MAGI1

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_001028229.1 Gene:MAGI1 / 9223 HGNCID:946 Length:1462 Species:Homo sapiens


Alignment Length:1418 Identity:233/1418 - (16%)
Similarity:419/1418 - (29%) Gaps:485/1418 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   968 PPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTS 1032
            ||..|..|                .|.|:..:.|:..|:..|:.....|:..|.::....|.:..
Human   192 PPSQPVSG----------------KVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240

  Fly  1033 RDNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDHAYIPWPAETPAASNLSASSSQNVSD----- 1092
            .|:...    ||....:|..||          |:|. :...|..|..|::.|:...:.|.     
Human   241 EDDVPE----MNSSFTADSGEQ----------EEHT-LQETALPPVNSSIIAAPITDPSQKFPQY 290

  Fly  1093 ---SIEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQMCVSPALRPYLCHMLS 1154
               |.||::.. :|.:.:.:...|    ...|..|   ......:.|...|::...:|    :..
Human   291 LPLSAEDNLGP-LPENWEMAYTEN----GEVYFID---HNTKTTSWLDPRCLNKQQKP----LEE 343

  Fly  1155 TKDAQG-------------------QTP-----FMLSVSCRA-YEAGIILLNTILMLSEQDPQLK 1194
            .:|.:|                   :.|     ::..::.:. ||..::.......|.:|..|.:
Human   344 CEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQ 408

  Fly  1195 EAM------------------------IFPNGSPADQSP-----------------------LH- 1211
            :..                        :.||..|::..|                       :| 
Human   409 QQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473

  Fly  1212 ---------------------------------------------VICYNDTCSFTWTGADHINQ 1231
                                                         ::..||||....|.|..:  
Human   474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVV-- 536

  Fly  1232 NIFECKTCGLTGSLCCC----------------------------------TECARVCHKGHDCK 1262
            .||:....|.:..|..|                                  |..:...|.....|
Human   537 KIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGK 601

  Fly  1263 ---LKRTAPTAYCDCWEKCKCKALIAGNLTKRF-----ALLCKLVSCTDLVTKFNSKGESILLFL 1319
               :|...|::..|          :|.|.:..:     :|...:.:..:|:|....||.....|.
Human   602 VNGMKDARPSSPAD----------VASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFT 656

  Fly  1320 I--------QTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLE 1376
            |        |.| :|||:      |.|.|.:.      .|:..|..|:|...|...|.:.|..:|
Human   657 IADSPGGGGQRV-KQIVD------SPRCRGLK------EGDLIVEVNKKNVQALTHNQVVDMLVE 708

  Fly  1377 PPKFARKALERLLIDWNAVRSMIMSGAERGDVP----NPAGSASENSNSEGFNMFIQTQHGSTLL 1437
            .||.:...   ||:             :||.:|    :|.....|..:|:.     .:||.    
Human   709 CPKGSEVT---LLV-------------QRGGLPVPKKSPKSQPLERKDSQN-----SSQHS---- 748

  Fly  1438 DKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARV--FVIFNLEKQP 1500
                       .|.|         |.|..||.|:    :.:|:..|..:.|:.  ....:.:|:|
Human   749 -----------VSSH---------RSLHTASPSH----STQVLPEFPPAEAQAPDQTDSSGQKKP 789

  Fly  1501 NPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALI--------------------APVR 1545
            :|                .|::.....:....|.:..|..|                    .|:.
Human   790 DP----------------FKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIY 838

  Fly  1546 LGVVRPTAPFTMSSSNLD--VRNSDDLFSVDPLAPSNVESPSEQI---LVHDAGNDQSANFNIQQ 1605
            :|.:.|     :.:::.|  :|:.|:|..||   .:.|...|.|:   |:..|......|..:::
Human   839 IGHIVP-----LGAADTDGRLRSGDELICVD---GTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 895

  Fly  1606 NYDVVAMETIRDASESEEVINREANSH---NQDDELIENQRNEDGMQDDESDNDFTFNDAETESD 1667
                   :.:....::|..:...|:||   ||...|.|.:|...|.|          |...|.|.
Human   896 -------KVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQ----------NSLNTVSS 943

  Fly  1668 SDDNQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNF----N 1728
            ...:.|      .:.:|...||    ||:....:..|...:.  |..:|        |.|    :
Human   944 GSGSTS------GIGSGGGGGS----GVVSTVVQPYDVEIRR--GENEG--------FGFVIVSS 988

  Fly  1729 EQQLERRSTNSNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRST--------V 1785
            ..:.|..:|..||...: |..:...|......|.. ::..|..::.::..::...:        .
Human   989 VSRPEAGTTFGNACVAM-PHKIGRIIEGSPADRCG-KLKVGDRILAVNGCSITNKSHSDIVNLIK 1051

  Fly  1786 PASTTVTTPSI--EPHTMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAV 1848
            .|..|||...|  :..:.||..:|..:...||.....      |.....:...:.|.:.:     
Human  1052 EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP------SQQGTQETRNTTKPKQE----- 1105

  Fly  1849 QAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSV 1913
            ..|..|..:||.:..|..::.......||..|....:.|..|:.|.|:....:.:.........:
Human  1106 SQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEI 1170

  Fly  1914 NGVNIMGSNSRRDFFTYCLSLMRSHTSEHR-------DALPVLDITALRHIAYVLDAFVYYMRND 1971
            ..:|  |..::....:..:.|:::.....|       .::|..|.::.||            ...
Human  1171 LEIN--GETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRH------------GPA 1221

  Fly  1972 SGFYDKQDTISGRINNLSPMTE-SYDTDDELANLEEFNADVQMSASSM-PSGS-----QGTRRHA 2029
            :|.....:..:|......|..| ||..|     |.:.:...:..|.:. |.||     |....|.
Human  1222 TGPQGVPEVRAGPDRRQHPSLESSYPPD-----LHKSSPHGEKRAHARDPKGSREYSRQPNEHHT 1281

  Fly  2030 FFARSESTLSLGC----SAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG 2090
            :...|....|..|    .||||...........|:.|....|..:|:                  
Human  1282 WNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRRE------------------ 1328

  Fly  2091 ATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGS 2143
            .|...|               |:|:|.|:..:...:...:..:.:.|.:.:||
Human  1329 GTRSAD---------------NTLERREKHEKRRDVSPERRRERSPTRRRDGS 1366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 16/103 (16%)
ASF1_hist_chap 1535..1733 CDD:304562 42/229 (18%)
PolyA 2498..2561 CDD:197769
HECTc 2589..2885 CDD:238033
HECTc 2589..2884 CDD:214523
MAGI1NP_001028229.1 PDZ_signaling 15..100 CDD:238492
GuKc 122..293 CDD:214504 25/131 (19%)
WW 303..332 CDD:238122 5/35 (14%)
WW 361..390 CDD:278809 3/28 (11%)
PDZ 469..555 CDD:214570 12/87 (14%)
PDZ 640..723 CDD:214570 27/111 (24%)
MAGI_u5 722..805 CDD:293271 21/131 (16%)
PDZ_signaling 819..894 CDD:238492 15/82 (18%)
PDZ_signaling 968..1062 CDD:238492 17/105 (16%)
PDZ 1123..1205 CDD:214570 11/83 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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