DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and UBE3B

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_569733.2	Gene:	UBE3B / 89910	HGNCID:	13478	Length:	1068	Species:	Homo sapiens

Alignment Length:	724	Identity:	150/724 - (20%)
Similarity:	278/724 - (38%)	Gaps:	186/724 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2257 YQKSTSDHLLLFPARGSQ--------------FYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDD 2307
            :|||.|...:|.|..|.:              .||::.:       .|::.:|.: |.|..::||
Human   434 FQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLT-------TLTQIRLQI-LTGLTYLDD 490

  Fly  2308 VGMEHGSVLPELRGFPVKEM----RFRRHMEKLRNGQQRD-------LVLCKLERNRESLI--VQ 2359
                   :||:|..| :.|:    ..:..:|.|.|..:..       ::.|...|:..:::  ::
Human   491 -------LLPKLWAF-ICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIE 547

  Fly  2360 TFKELNTQFGNQSRRIQPPITFNRVKVTFK-DEPGEGSGVARSF-YTSIAEALLASAKIPNLESV 2422
            .::|                     :::|| :|....|....|| :..|.:.::.:||...||..
Human   548 VYEE---------------------QISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELF 591

  Fly  2423 QVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSA---RERKALNLDARPYTPP 2484
            |  :.|...:|.:....|.|..     .:....|:.....:|::..   |:|..|.|...|:..|
Human   592 Q--SVHGWLMVLYERDCRRRFT-----PEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIP 649

  Fly  2485 N---------------------SSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGM 2528
            :                     .:.:|:|..  .|:::...::.|..|.::..::| ||.|   .
Human   650 HKNRVLLFRTMVTKEKEKLGLVETSSASPHV--THITIRRSRMLEDGYEQLRQLSQ-HAMK---G 708

  Fly  2529 LLEIPTPQLLSV----ISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDN 2589
            ::.:.....|.|    |..|...::.:.|.|:.:.                .|::.:......|
Human   709 VIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVF----------------DPALNLFKTTSGD- 756

  Fly  2590 EPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFH 2654
            |.|:.||         ..:.....:..|..:|:::|..:.:..::.:......|..:||.    |
Human   757 ERLYPSP---------TSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGH----H 808

  Fly  2655 DLAFFD-----PALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAV 2714
            ...|:.     |:|...|.:.:.:.:..:|:.|...:.|.:..|:|.:..|  .||||||:.:.|
Human   809 HSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVC--HELIPGGKTIPV 871

  Fly  2715 TSSNIFEYVRRYTEYRL---IKSQEKALEALKDGVFDVL-PDNSMINLTAEDLRLLLNGVGDINV 2775
            |:.|...|:.....:|:   ||:|..||.:   |...:: |:...:..|.|..||:.....:|::
Human   872 TNENKISYIHLMAHFRMHTQIKNQTAALIS---GFRSIIKPEWIRMFSTPELQRLISGDNAEIDL 933

  Fly  2776 STLISYTTFNDESSEGPDKLLKFKKWFWSIV-EKMNIMERQDLVYFWTGSPALPASEEGFQPL-P 2838
            ..|..:|.:.. ...|..:::   .|.|.|: ......||...:.|.|.....|..  ||..| |
Human   934 EDLKKHTVYYG-GFHGSHRVI---IWLWDILASDFTPDERAMFLKFVTSCSRPPLL--GFAYLKP 992

  Fly  2839 SVTIR---PADD-----------------------SHLPTANTCISRLYIPLYSSKSILRSKMLM 2877
            ..:||   .:||                       ..|||::||.:.|.:|.||.||:||.|:..
Human   993 PFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRY 1057

  Fly  2878 AIKSKNFGF 2886
            || |.|.||
Human  1058 AI-SMNTGF 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	13/66 (20%)
		HECTc	2589..2885	CDD:238033	81/332 (24%)
		HECTc	2589..2884	CDD:214523	80/331 (24%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	98/430 (23%)
UBE3B	NP_569733.2	HECTc	707..1065	CDD:214523	90/402 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900