DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and HERC3

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_055421.1 Gene:HERC3 / 8916 HGNCID:4876 Length:1050 Species:Homo sapiens


Alignment Length:893 Identity:174/893 - (19%)
Similarity:299/893 - (33%) Gaps:272/893 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2181 ETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLK----TIDSDINNYS 2241
            |.|...|...|    |:.|:..|.|:..:...:..|.:..|.....|||.:    :::.::|...
Human   227 EKDRESPCHVK----LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRR 287

  Fly  2242 ASNLSTAE--QAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVF 2304
            ...|..:|  |..|..|       |.|.|              :||...:.:        ||...
Human   288 VLELMGSEVTQIACGRQ-------HTLAF--------------VPSSGLIYA--------FGCGA 323

  Fly  2305 MDDVGMEHGSVL---PELRGF--------PVKEMRFRRHMEK-LRNGQQRDLVLCKLERN----- 2352
            ...:|..|...:   ..::|:        ..:..||:.|:.| :.:|..:..|||....|     
Human   324 RGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAV 388

  Fly  2353 ----------------------RESL-----------IVQTF------------KELNTQFGNQS 2372
                                  |:.|           :||..            |:::..| ..|
Human   389 DFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHF-KTS 452

  Fly  2373 RRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALL----------ASAKIPNLESVQVG-- 2425
            .:| |.|..|..:|.|:.       :..|.::.|.|.:|          .|:..|::|::::.  
Human   453 PKI-PGIDLNSTRVLFEK-------LMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLI 509

  Fly  2426 ------TNHSKYVVPFS-----SILRSRTVSGSSRDQSTLQRRGSNSKIL---WRSARER---KA 2473
                  ...|||.:..:     :|||..|               :.||:|   |.....:   |.
Human   510 LPEFPLLQDSKYYITLTIPLAMAILRLDT---------------NPSKVLDNWWSQVCPKYFMKL 559

  Fly  2474 LNL--DARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYP---KIHSI--NQTHAPKITGMLLE 2531
            :||  .|..|..........|...|::::..|:.: |:||.   |:..:  :..:.|:|:. |::
Human   560 VNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLL-EKLYKVNLKVKHVEYDTFYIPEISN-LVD 622

  Fly  2532 IPTPQLL----------------------------------SVISSDETLRQKV-------NEAI 2555
            |....|:                                  .::.:|..|:.:|       ....
Human   623 IQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVF 687

  Fly  2556 EIITFK---------------------QKSETSAQSSQPKKSPSVVVVD---PVDDDN------- 2589
            .::|.:                     ...|.|..|....|.|..|:.|   .||...       
Human   688 MLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFL 752

  Fly  2590 -------EPLFYSPGKRGFYTPRQG-----FAS--FERINAFRNIGRLIGLCLLQNELLPLFLQR 2640
                   .|::      |.:|..|.     |:.  |...|.|..||...||.:..:.::.|....
Human   753 LLLKELLNPIY------GMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPL 811

  Fly  2641 HVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEE--GCGNR 2703
            .:.|.:|..|....||....|....|.:::: :...::.|||     .|....:.:|.  ....:
Human   812 ALYKKLLNVKPGLEDLKELSPTEGRSLQELL-DYPGEDVEET-----FCLNFTICRESYGVIEQK 870

  Fly  2704 ELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLN 2768
            :|||||.:|.|...|..|:|..|..|....|..:...|...|...|.....:......:||.::.
Human   871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMV 935

  Fly  2769 GVGDINVSTLISYTTF-NDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEE 2832
            |..:.|...|.....: .|.|:..|.     .|.||....:..:.:::..:.|.|||..:|.  .
Human   936 GNSNYNWEELEETAIYKGDYSATHPT-----VKLFWETFHEFPLEKKKKFLLFLTGSDRIPI--Y 993

  Fly  2833 GFQPLPSVTIRPAD-DSHLPTANTCISRLYIPLYSSKSILRSKMLMAI 2879
            |...|..|....|. :.:||.|:||.:.|.:|.||||.||.:::..|:
Human   994 GMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQAL 1041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562
PolyA 2498..2561 CDD:197769 14/108 (13%)
HECTc 2589..2885 CDD:238033 75/316 (24%)
HECTc 2589..2884 CDD:214523 75/316 (24%)
HERC3NP_055421.1 RCC1 1 1..51
ATS1 2..331 CDD:227511 27/136 (20%)
RCC1 2 52..101
RCC1 3 102..154
RCC1 4 156..207
RCC1 5 208..259 8/35 (23%)
RCC1 6 261..311 13/70 (19%)
RCC1 313..377 CDD:366085 10/71 (14%)
RCC1 7 313..366 8/60 (13%)
HECTc 702..1048 CDD:238033 84/359 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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