DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and RSP5

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_011051.3	Gene:	RSP5 / 856862	SGDID:	S000000927	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	856	Identity:	175/856 - (20%)
Similarity:	302/856 - (35%)	Gaps:	252/856 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2122 ETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSL 2186
            ||:..|..|:.||.       :....:.|.|.|...|   ..|.:|...          .|..|.
Yeast   112 ETITRDLKKSNDGM-------AVSGRLIVVLSKLPSS---SPHSQAPSG----------HTASSS 156

  Fly  2187 PSTSKST----EALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLST 2247
            .:||.:|    .:..:||......|::.:   |.|..|  .|..|:...|     |..:.|:.||
Yeast   157 TNTSSTTRTNGHSTSSTRNHSTSHPSRGT---AQAVES--TLQSGTTAAT-----NTATTSHRST 211

  Fly  2248 AEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVF-------- 2304
            ...:....||..                ::..:..||      ..|:...|.|||.:
Yeast   212 NSTSSATRQYSS----------------FEDQYGRLP------PGWERRTDNFGRTYYVDHNTRT 254

  Fly  2305 -------MDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFK 2362
                   :|....|.|:.|.     ...|:..|:|..:...|...|         ..|:.||...
Yeast   255 TTWKRPTLDQTEAERGNQLN-----ANTELERRQHRGRTLPGGSSD---------NSSVTVQVGG 305

  Fly  2363 ELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTN 2427
            ..|.          ||:                :|.|.:.:.:.........::|
Yeast   306 GSNI----------PPV----------------NGAAAAAFAATGGTTSGLGELP---------- 334

  Fly  2428 HSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATP 2492
             |.:...|:...|:..|..::|..:            |...|.::.:    |.|.|.|::....|
Yeast   335 -SGWEQRFTPEGRAYFVDHNTRTTT------------WVDPRRQQYI----RTYGPTNTTIQQQP 382

  Fly  2493 ESLNDHLSVHLQQIG-------------ERLYPKIHSINQT--HAPKITGMLLEIPTPQLLSVIS 2542
            .|          |:|             .|:|...|:...|  ..|::... |:...||.
Yeast   383 VS----------QLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSS-LDQNVPQY----- 431

  Fly  2543 SDETLRQKV-----NEAIEI------ITFKQKS-------ETSAQSSQPKKSPSVVVVDPVDDDN 2589
             ....|:||     ..|:.|      |..::|:       |...|:.:..|...::..    |..
Yeast   432 -KRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKF----DGE 491

  Fly  2590 EPLFYSPGKRGFY---------------------------TPRQGFASFERINAFRNIGRLIGLC 2627
            |.|.|....|.|:                           .|..|. :.|.:|.|:.|||::||.
Yeast   492 EGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGI-NPEHLNYFKFIGRVVGLG 555

  Fly  2628 LLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVI 2692
            :.....|..|....:.|.:|.:|:...|:...|..:|.|...:::|  :.:|.     ::|.|..
Yeast   556 VFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLEN--SIDGV-----LDLTFSA 613

  Fly  2693 DLMKEEGCG---NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNS 2754
            |   :|..|   ..:|.|.||::.||..|..|||..||::|::...::..:|..||..:::|::.
Yeast   614 D---DERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDL 675

  Fly  2755 MINLTAEDLRLLLNGVGDINVSTLISYTTFN--DESSEGPDKLLKFKKWFWSIVEKMNIMERQDL 2817
            :......:|.||:.|:.:|::.....:|.:.  .||.|       ..:|||..|.:.:..:|..|
Yeast   676 VTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDE-------VIQWFWKCVSEWDNEQRARL 733

  Fly  2818 VYFWTGSPALPASEEGFQPLPS------VTIRPADD-SHLPTANTCISRLYIPLYSSKSILRSKM 2875
            :.|.||:..:|.:  ||:.|..      .||..|.: ..||.::||.:|:.:|.|.....::.|:
Yeast   734 LQFTTGTSRIPVN--GFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKL 796

  Fly  2876 LMAIKSKNFGF 2886
            .:|:: :..||
Yeast   797 TLAVE-ETIGF 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	16/88 (18%)
		HECTc	2589..2885	CDD:238033	82/334 (25%)
		HECTc	2589..2884	CDD:214523	82/333 (25%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	175/856 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900