DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and TOM1

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_010745.3 Gene:TOM1 / 852068 SGDID:S000002865 Length:3268 Species:Saccharomyces cerevisiae


Alignment Length:3153 Identity:597/3153 - (18%)
Similarity:1063/3153 - (33%) Gaps:1024/3153 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 TGVIIG-----GSTSSRP-------------LVTVPATYVPEELISQAEVVLQ---GKSRNLIIR 177
            |.|:.|     ||.|..|             :...|..|.....||....|||   .|..:....
Yeast   737 TSVLFGMSLGNGSFSQVPQHLEARDFLAIIFMENPPYEYFTSVAISNVTEVLQYLDEKYEDYAFM 801

  Fly   178 ELQRTNLDVNLAVNNLLSRDDEEAEDTEEGADNYVPE---------DLISLLDNGFSGDNNSVII 233
            ::.:...|....:|:.|:..::.:...|...:|.|..         .:::::.|        |.|
Yeast   802 DVMKVLNDQLENLNDFLNSPNDRSFFLERDGENSVRSCHSKLCRLAAILNIVTN--------VYI 858

  Fly   234 DPSDGLFSEEIFSNY--------SSIRN--LLFDRIRSERSNANANAADSNQSTTRSTSSGTALT 288
            |.:. |..:.|...|        |.|:|  |||.:...|......:..||            .:|
Yeast   859 DLTT-LSCKRIMQIYSYFDKRGFSLIKNLKLLFQKCALEEMYIRQHMPDS------------VIT 910

  Fly   289 GNSGLSAQISVNADREAFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEPSPMLSPIWISEELQ 353
            ....|.. :.|:.|             ||...|..||   .|..|.|.|..|.            
Yeast   911 ETMPLPI-VDVSGD-------------GPPLQIYIDD---PKKGDQKGKITSV------------ 946

  Fly   354 PWPEKSSVRFKTI--------GALYSEFIALSESGDLYQWRWSDAEPYKSETENVYHPKTVSLNI 410
              ..:::::.:||        ..|:..|:.||.|.::      |.| :|..|..|:..:.|..|:
Yeast   947 --KTRNTLQMRTILYTLQSNTAILFRCFLRLSHSRNM------DLE-HKDLTTEVHIFENVVENV 1002

  Fly   411 VERVELISANFIRCSVVTETNRVATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVV 475
            :|.::                  ||.::..|.||...|.     ||.|:            :|:.
Yeast  1003 IEMLK------------------ATELEGHLPYILVLLN-----FNTFV------------FTIP 1032

  Fly   476 KTESNNIYWWGVLP---FDQR-------RFLWDKFRTKTKKPFKVVATDINVG----------AQ 520
            |...|:......:|   |.|:       ..:.|.|...||  .|.:::..|:.          ..
Yeast  1033 KASPNSTEILQTIPAYIFYQKGGYLLYLHIIRDLFTRMTK--IKDLSSLDNINYIDESNGILTLS 1095

  Fly   521 VIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCR-----MKIININTNSGVDKSQAAGN 580
            .::.....|.......|..| |..:|:...|:....::.:     :|::.:.....:|||.:...
Yeast  1096 CLINALTFYNKSMQTETMEN-VQSIGKYYVSIDDDYNIMKALTVPIKVMALAMILDLDKSDSLFK 1159

  Fly   581 NLNAHGITPDKDLPKSTAMPSTGSSKNGQSFSNSKESTDRI-----DM--PP------------P 626
                   |..:::|.|.........||  .|:|....|..:     |:  ||            |
Yeast  1160 -------TQSRNVPYSVFKQLLSMLKN--IFTNVNIYTKELYELHWDLIFPPIKKISLFEQVGIP 1215

  Fly   627 PSPASSTCSDTG------------SVTSHKRTKRATTKEDS-NAPQ-------EGRKDEELWEVK 671
            ...|::..:|||            |....::.|:...::.| ..||       :|...:||.|::
Yeast  1216 GDVAANYLTDTGDDLPADNSIGLFSPEQWEKYKKLIGEDKSIYYPQPMQAQYYKGCSSKELDELR 1280

  Fly   672 DVVFVEDKVGPVGKVLKVDGDFVAVRFP-AINAAAVAAAAAATSSTSNT---ASTSKEEGKEDDW 732
            |..|.:.....:..||..        :| .:||.|.......|.....|   |....:...|.|.
Yeast  1281 DTFFNDGLPSRIFTVLPF--------YPKLVNAFAKTLLQIFTKYDEPTEVFAGRILDRILETDL 1337

  Fly   733 QQCRLLRR---------EDVQIFRTA--MSTRGPDWLQK--QPKKINVGGDAAGAQILTLAVDSR 784
            .....|..         .:..|::.|  :..|..::|:|  :|:.:|.            ...|:
Yeast  1338 DDPATLSSLIHLFGIFLNEKYIYQKASHLMQRFIEYLEKSLKPEHVNT------------PWFSK 1390

  Fly   785 GIHVIKKVLGK--------------IHYSLYNLYN-------CKQEQNCLFP-----TDCNSFIG 823
            .::|.:.:|.|              :.|.|.::..       .||:   ||.     :|.::|..
Yeast  1391 ALYVYEIILAKSELPHLEELSKDVLLRYPLLSMAKVFRIPDPMKQK---LFDILIRVSDISNFYS 1452

  Fly   824 --STPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLP 886
              :|...::....|:...|:   :.|  :|.|..|.| .:||.:                     
Yeast  1453 ALATSRILIFYSRDELYANN---IAR--SGILSRLLK-VIGSFQ--------------------- 1490

  Fly   887 AMLSGVNL--KSKVCMTALLFDTQKLMPHILRCDVKNSFAA--LGRLEREDQA--DTALVVEERC 945
             .|..:|.  .|.:.:|...|:|.:.:..::|.::..||.|  ||   ..|.|  :...::||: 
Yeast  1491 -KLDKINFLESSFLLLTRRCFETTENVDALIRAEINRSFTARPLG---GGDDAVRELTTILEEK- 1550

  Fly   946 DGARNIFHACVIMCAPSSNKDSPPDSPSGGV--EKKSLVGLSVARSIPTVSTSAYVSSIAFGASA 1008
                    |.|:|.:||...|...::.....  ::.:||..|:.|.:                  
Yeast  1551 --------AHVVMRSPSQFIDVLCETARFHEFDDQGALVDYSLKRFL------------------ 1589

  Fly  1009 SSSNENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDHAYIPWP 1073
            ...::|:           .||||.:.:......:|:.|:         ||.||.:.:|     | 
Yeast  1590 GEKDKNT-----------QASSTEKSDIYERTGIMHLLL---------SQLMAASEKD-----W- 1628

  Fly  1074 AETPAASNLSASSSQNVSDSIEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQ 1138
                                                      |..|..:.||.:.::..|     
Yeast  1629 ------------------------------------------LSEPANSSDLPENKKAQL----- 1646

  Fly  1139 MCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQDPQLK-EAMIFPNG 1202
               .|:..|...:|                        |.||..::.|.....|.| |.:.|...
Yeast  1647 ---DPSRNPVCAYM------------------------IFLLKLLVELVSSYNQCKFEFLTFSRR 1684

  Fly  1203 SPADQSP------LHVICYN--DTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGH 1259
            :...:.|      ::...|.  |..    .|.||   :..|.|...:.|.|      ||....|.
Yeast  1685 NTYAERPRPRTTAINFFLYRLLDKP----VGTDH---DKHEAKRREVIGML------ARSVIIGF 1736

  Fly  1260 DCKLKRTAPTAYCDCWEKCKCKALIAG---NLTKRFAL--LCKLVSCTDLVTKFNSKGESILL-- 1317
            ...::....|         |....:|.   |..::||:  :.|.:.        |:...|.||  
Yeast  1737 LATVQDDRTT---------KTDVKLADPHMNFIRKFAIEAIIKAIR--------NATSSSKLLES 1784

  Fly  1318 ---------------------FLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKT 1361
                                 :|.|.:....||..||:....|.::        |..|||:.   
Yeast  1785 NHLKLDMWFRIITSMVYVQAPYLRQLLDSNKVEADQYQLCKLVIDL--------GLPSVITE--- 1838

  Fly  1362 SAAEIDNDMPDHDLEPPKFARK----ALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSE 1422
            :.|.||.:.|        |::|    |:|.|    |.:                  |::.|:.||
Yeast  1839 AMASIDLNYP--------FSKKIFNVAVEAL----NTI------------------SSTRNNFSE 1873

  Fly  1423 GFNM--------FIQTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEV 1479
            .|.:        .:.......:.|.|.:|           .|.:..|.:::.....:.|...::.
Yeast  1874 HFKIEDHDEVEDEVDESDKEEIPDMFKNS-----------ALGMYDVEDIEEDDDDDTSLIGDDD 1927

  Fly  1480 VRRFVRSVARVFVIFNLEK----QPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEAL 1540
            ...||.|.....|:|:.|.    :.:.:..:|.|..|              ::|.|         
Yeast  1928 AMAFVDSDNGFEVVFSDEDDDMGEEDADDARSDSEEN--------------ELSSE--------- 1969

  Fly  1541 IAPVRLGVVRPTAPFTMSSSNLDVRNSD-DLFSVDPLAPSNVESPS---EQILVHDAGNDQSANF 1601
                            |.||..|..:.| ::...|.|. .|::.||   |::..:||....|:: 
Yeast  1970 ----------------MQSSTADGTDVDYEVDDADGLI-INIDQPSGDDEEMADYDANISHSSH- 2016

  Fly  1602 NIQQNYDVVAMETIRDASESEEVINREANSHNQDDELIENQRNEDGMQDDESDNDFTFNDAETE- 1665
              .:|.|..:|:.|       ||         .||||      ..|...|.||.|...:|.::. 
Yeast  2017 --SENEDDASMDVI-------EV---------YDDEL------SSGYDVDLSDYDVDESDWDSGL 2057

  Fly  1666 -----SDSDDNQSNQEVQRSVQAGAT----VGSENDIGVLFLEDESGDSSAQEED-----GSEDG 1716
                 ||.|...|..|...|.:.|.:    :.:|   ||...:|..|:|  :|:|     |.|..
Yeast  2058 SSLSISDEDSESSEDEPINSTRMGDSRRRWLIAE---GVELTDDSQGES--EEDDRGVFRGIEHI 2117

  Fly  1717 ESDDQSDEFNFNEQQLER---RSTN-----------------------SNARSDLAPQTMQWA-- 1753
            .|::....|..:::...|   ||.|                       ||..:.|.|..::..  
Yeast  2118 FSNENEPLFRVHDEMRHRNHHRSINRTHFHSAMSAPSLSLLNRGRRNQSNLINPLGPTGLEQVEN 2182

  Fly  1754 -IRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPHTMATTASNLARAFGI--- 1814
             |..:.|...|...|...::.|.:.:.       :.:....|.::...:.:|.|.....|.:   
Yeast  2183 DISDQVTVAGSGSRPRSHHLHFSEVLV-------SGSFFDEPVLDGIILKSTVSRWKDIFDMFYD 2240

  Fly  1815 -------TIRQISELISILSYNVLNDIETSL---KIQNDEAIAVQAFVEKRLKATWDWMFTVMDG 1869
                   .|..:...:..:|..:..|:|...   |::|...:..:|.||....:  |.:....|.
Yeast  2241 SKTYANCIIPTVINRLYKVSLALQKDLENKREQEKLKNKNLLFNEAKVESHNSS--DAISVEQDD 2303

  Fly  1870 TEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSL 1934
            .:.        :|.|..:|  .|:.::.|  .|:.....|......:|.:..:.|.|.|.     
Yeast  2304 IQE--------SNVTHDDH--EPVYVTIQ--GSEVDIGGTDIDPEFMNALPDDIRADVFA----- 2351

  Fly  1935 MRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRND--SGFYD---KQDTISGRINNLSPMTES 1994
              .|..|.| |...|:.....|...:...|:..:..|  .|..|   ::..:.|||.:.:.:..:
Yeast  2352 --QHVRERR-AEARLNSDHNVHSREIDSDFLEAIPEDIREGILDTEAEEQRMFGRIGSSADVIRA 2413

  Fly  1995 YDTDDELANLEEFNADVQMSASSMPSGSQGTRRHA----------FFARSESTLSLGCSAPEGFE 2049
               ||:::|.:|   :|:   :.:..|:...|.:|          :||                 
Yeast  2414 ---DDDVSNNDE---EVE---NGLDHGNSNDRNNADPEKKKPARIYFA----------------- 2452

  Fly  2050 LPLDMAMPLADKP---------HLLQPNSKRQ---ELFANLPLLVTTNANNSGATND-----GDG 2097
                   ||.|:.         .:.:|..:|:   |||..   |.::..|.:...|.     .:|
Yeast  2453 -------PLIDRAGIASLMKSVFISKPYIQREIYHELFYR---LCSSKQNRNDLMNTFLFILSEG 2507

  Fly  2098 GSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTD------SNIYVQLKKKQ 2156
              |.|        .:||   |:||..  |.|...|....|...:..:|      :|..:::    
Yeast  2508 --IID--------QHSL---EKVYNI--ISSRAMGHAKTTTVRQLPSDCTPLTVANQTIEI---- 2553

  Fly  2157 GSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAP--------NKASVS 2213
                .:|..:||   |:.:..::.|.|:.:.:.:.:.....|...:.:..|        ::..::
Yeast  2554 ----LQSLIDAD---SRLKYFLIAEHDNLIVNKANNKSRKEALPDKKLRWPLWHLFSLLDRKLIT 2611

  Fly  2214 PATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQS 2278
            ..:....::......|.||:         :.|||:...|          ::|      ..:|:..
Yeast  2612 DESVLMDLLTRILQVCTKTL---------AVLSTSSNGK----------ENL------SKKFHLP 2651

  Fly  2279 NFSELPSWNFLLSRWKLTLD-LFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQR 2342
            :|.|......|..   :.|| ...|||...:.:.:.  |.:|:|.   ...|.:|:..|...   
Yeast  2652 SFDEDDLMKILSI---IMLDSCTTRVFQQTLNIIYN--LSKLQGC---MSIFTKHLVSLAIS--- 2705

  Fly  2343 DLVLCKLER-----NRESLIVQTFKELNTQF--------GNQSRRIQPPITFNRVKVTFKDEPGE 2394
              ::.||:.     :||...:.|..|:|::.        .:|::.::...|.:.:....:.|...
Yeast  2706 --IMSKLKSALDGLSREVGTITTGMEINSELLQKFTLPSSDQAKLLKILTTVDFLYTHKRKEEER 2768

  Fly  2395 GSGVARSFY---------TSIAEAL-----------LASAKIPNLESVQVGTNHSKYVVPFSSIL 2439
            .....:|.|         :|::|.|           .|:..:|.:||:.|       |...|.:.
Yeast  2769 NVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLPLIESLMV-------VCRRSDLS 2826

  Fly  2440 RSRTVSGSSRDQSTL---QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSV 2501
            ::|..:....|...|   :.|..|....:..| .:|.||...|          :.|:.::...::
Yeast  2827 QNRNTAVKYEDAKLLDFSKTRVENLFFPFTDA-HKKLLNQMIR----------SNPKLMSGPFAL 2880

  Fly  2502 HLQ-----QIGERLY---PKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIE-- 2556
            .::     ....:.|   .|:.|.|| ..||:.   :.:...|:.  :.|...|..|.|:.|:  
Yeast  2881 LVKNPKVLDFDNKRYFFNAKLKSDNQ-ERPKLP---ITVRREQVF--LDSYRALFFKTNDEIKNS 2939

  Fly  2557 --IITFKQKSETSAQS---------SQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFAS 2610
              .||||.:|...|..         |:...:|...:..||..|         |..|:..|....:
Yeast  2940 KLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSD---------KTTFHPNRTSGIN 2995

  Fly  2611 FERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQ 2675
            .|.::.|:.||.:||..:.....|.....|.|.|.||||.:...|:...||..|:|...|::|..
Yeast  2996 PEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILENDI 3060

  Fly  2676 TKEGEETINRMELCFVIDLMKEEGCGNRE---LIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEK 2737
            |...|||.:          ::.:..|..:   ||.||:|:.||.:|..:||::..||:|..|.::
Yeast  3061 TDIIEETFS----------VETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKE 3115

  Fly  2738 ALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINV------STLISYTTFNDESSEGPDKLL 2796
            .::....|.:.::..:.:.....::|.||::|:.||:|      :|.::||....|.|       
Yeast  3116 QMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEVS------- 3173

  Fly  2797 KFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSV------TIRP--ADDSHLPTA 2853
                :||..|...:..||..|:.|.||:..:|.:  ||:.|..|      :|..  .....||::
Yeast  3174 ----YFWRAVRSFDAEERAKLLQFVTGTSKVPLN--GFKELSGVNGVCKFSIHRDFGSSERLPSS 3232

  Fly  2854 NTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            :||.::|.:|.|.|...||..:|:||...:.||
Yeast  3233 HTCFNQLNLPPYESYETLRGSLLLAINEGHEGF 3265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409 11/48 (23%)
ZnF_UBR1 1217..1284 CDD:197698 13/66 (20%)
ASF1_hist_chap 1535..1733 CDD:304562 49/216 (23%)
PolyA 2498..2561 CDD:197769 15/74 (20%)
HECTc 2589..2885 CDD:238033 84/312 (27%)
HECTc 2589..2884 CDD:214523 84/311 (27%)
TOM1NP_010745.3 DUF908 92..387 CDD:399185
DUF913 448..>683 CDD:399192
MSCRAMM_ClfB <1879..2061 CDD:411414 47/257 (18%)
DUF4414 2328..2357 CDD:405126 6/35 (17%)
HUL4 2385..3268 CDD:227354 215/1037 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.